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Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study.
Medicine (Baltimore) 2019; 98(4):e14128M

Abstract

To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365.2), between 1998 and 2011 and had undergone cataract surgery alone (CS), glaucoma surgery alone (GS), or CGS under the National Health Insurance program in Taiwan. CS, GS, and CGS in all the patients were performed after the glaucoma diagnosis date. The patients were subdivided into CS, CGS, and GS groups. The number of glaucoma medications, including prostaglandin analogs, β-blockers, carbonic anhydrase inhibitors, α-agonists, pilocarpine, and a combination of drugs, in each prescription, were compared before and after surgery.The mean number of glaucoma medications in each prescription before the surgery increased from approximately 0.5/1 (CS/CGS + GS) to a peak of 1.75/3 within 3 months before the index date. The mean number of glaucoma medications in each prescription reduced to 0 (CS group) and to approximately 0.5 (CGS and GS) at the end of the 3-year follow-up period. The mean number of glaucoma medications in each prescription significantly reduced at the time points within 6 months, between 6 months and 2 years, and during 2 to 3 years after surgery in each group. At the end of the 3-year period, the reduction effect was most evident in the CS group. Similar trends were also observed in the POAG and PACG group.CS, GS, and CGS significantly reduced the number of glaucoma medications used by the glaucoma patients.

Authors+Show Affiliations

College of Medicine. Department of Ophthalmology.College of Medicine. Management Office for Health Data.Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine. Department of Nuclear Medicine and PET Center, China Medical University Hospital. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30681574

Citation

Chen, Hsin-Yi, et al. "Changes in Glaucoma Medication Numbers After Cataract and Glaucoma Surgery: a Nationwide Population-based Study." Medicine, vol. 98, no. 4, 2019, pp. e14128.
Chen HY, Lin CL, Kao CH. Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study. Medicine (Baltimore). 2019;98(4):e14128.
Chen, H. Y., Lin, C. L., & Kao, C. H. (2019). Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study. Medicine, 98(4), pp. e14128. doi:10.1097/MD.0000000000014128.
Chen HY, Lin CL, Kao CH. Changes in Glaucoma Medication Numbers After Cataract and Glaucoma Surgery: a Nationwide Population-based Study. Medicine (Baltimore). 2019;98(4):e14128. PubMed PMID: 30681574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study. AU - Chen,Hsin-Yi, AU - Lin,Cheng-Li, AU - Kao,Chia-Hung, PY - 2019/1/26/entrez PY - 2019/1/27/pubmed PY - 2019/2/5/medline SP - e14128 EP - e14128 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 4 N2 - To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365.2), between 1998 and 2011 and had undergone cataract surgery alone (CS), glaucoma surgery alone (GS), or CGS under the National Health Insurance program in Taiwan. CS, GS, and CGS in all the patients were performed after the glaucoma diagnosis date. The patients were subdivided into CS, CGS, and GS groups. The number of glaucoma medications, including prostaglandin analogs, β-blockers, carbonic anhydrase inhibitors, α-agonists, pilocarpine, and a combination of drugs, in each prescription, were compared before and after surgery.The mean number of glaucoma medications in each prescription before the surgery increased from approximately 0.5/1 (CS/CGS + GS) to a peak of 1.75/3 within 3 months before the index date. The mean number of glaucoma medications in each prescription reduced to 0 (CS group) and to approximately 0.5 (CGS and GS) at the end of the 3-year follow-up period. The mean number of glaucoma medications in each prescription significantly reduced at the time points within 6 months, between 6 months and 2 years, and during 2 to 3 years after surgery in each group. At the end of the 3-year period, the reduction effect was most evident in the CS group. Similar trends were also observed in the POAG and PACG group.CS, GS, and CGS significantly reduced the number of glaucoma medications used by the glaucoma patients. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/30681574/Changes_in_glaucoma_medication_numbers_after_cataract_and_glaucoma_surgery:_A_nationwide_population_based_study_ L2 - http://Insights.ovid.com/pubmed?pmid=30681574 DB - PRIME DP - Unbound Medicine ER -