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Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease.
Nephrology (Carlton). 2019 Aug; 24(8):781-790.N

Abstract

Patients with chronic kidney disease (CKD) experience excess cardiovascular morbidity and mortality that is unexplained by traditional cardiovascular risk factors. Vitamin D deficiency is highly prevalent in CKD and is associated with increased cardiovascular mortality in both the general population and in CKD patients. Vitamin D supplementation is a reasonably safe and simple intervention and meta-analyses of observational studies have suggested that vitamin D supplementation in CKD improves cardiovascular mortality. However, randomized controlled trials examining the impact of vitamin D supplementation in improving surrogate markers of cardiovascular structure and function remain inconclusive. This review investigates the impact of vitamin D supplementation on surrogate end-points and cardiovascular events from trials in CKD; and discusses why results have been heterogenous, particularly critiquing the effect of different dosing regimens and the failure to take into account the implications of vitamin D supplementation in study participants with differing vitamin D binding protein genotypes.

Authors+Show Affiliations

Renal and Transplantation Unit, St George's University Hospital NHS Foundation Trust, London, UK. Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.The George Institute of Global Health, Oxford, UK. University of Oxford, Oxford, UK.Renal and Transplantation Unit, St George's University Hospital NHS Foundation Trust, London, UK. Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30684283

Citation

Junarta, Joey, et al. "Insight Into the Impact of Vitamin D On Cardiovascular Outcomes in Chronic Kidney Disease." Nephrology (Carlton, Vic.), vol. 24, no. 8, 2019, pp. 781-790.
Junarta J, Jha V, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology (Carlton). 2019;24(8):781-790.
Junarta, J., Jha, V., & Banerjee, D. (2019). Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology (Carlton, Vic.), 24(8), 781-790. https://doi.org/10.1111/nep.13569
Junarta J, Jha V, Banerjee D. Insight Into the Impact of Vitamin D On Cardiovascular Outcomes in Chronic Kidney Disease. Nephrology (Carlton). 2019;24(8):781-790. PubMed PMID: 30684283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. AU - Junarta,Joey, AU - Jha,Vivekanand, AU - Banerjee,Debasish, Y1 - 2019/05/02/ PY - 2019/01/21/accepted PY - 2019/1/27/pubmed PY - 2020/2/6/medline PY - 2019/1/27/entrez KW - cardiovascular disease KW - chronic kidney disease KW - endothelial function KW - flow-mediated dilatation KW - vitamin D SP - 781 EP - 790 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 24 IS - 8 N2 - Patients with chronic kidney disease (CKD) experience excess cardiovascular morbidity and mortality that is unexplained by traditional cardiovascular risk factors. Vitamin D deficiency is highly prevalent in CKD and is associated with increased cardiovascular mortality in both the general population and in CKD patients. Vitamin D supplementation is a reasonably safe and simple intervention and meta-analyses of observational studies have suggested that vitamin D supplementation in CKD improves cardiovascular mortality. However, randomized controlled trials examining the impact of vitamin D supplementation in improving surrogate markers of cardiovascular structure and function remain inconclusive. This review investigates the impact of vitamin D supplementation on surrogate end-points and cardiovascular events from trials in CKD; and discusses why results have been heterogenous, particularly critiquing the effect of different dosing regimens and the failure to take into account the implications of vitamin D supplementation in study participants with differing vitamin D binding protein genotypes. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/30684283/Insight_into_the_impact_of_vitamin_D_on_cardiovascular_outcomes_in_chronic_kidney_disease_ L2 - https://doi.org/10.1111/nep.13569 DB - PRIME DP - Unbound Medicine ER -