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Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam.
J Glob Antimicrob Resist. 2019 09; 18:34-36.JG

Abstract

OBJECTIVES

The antimicrobial susceptibility pattern of clinical Burkholderia pseudomallei (B. pseudomallei) in Vietnam has not been reported since the first publication in 2008. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary referral centre in Hanoi from January 2012 to December 2017.

METHODS

A total of 312 B. pseudomallei isolates obtained from melioidosis patients admitted to a 2000-bed general hospital were analysed by the Etest method. Interpretation of the susceptibility testing results were reported using Clinical and Laboratory Standards Institute guidelines.

RESULTS

All isolates were susceptible to ceftazidime, imipenem and amoxicillin-clavulanate (100%) with MIC90s relatively low (2μg/mL). Two isolates had intermediate resistance to doxycycline (0.6%) and 34 isolates were resistant to trimethoprim/sulfamethoxazole (10.9%).

CONCLUSION

The results of this study suggest that currently recommended antibiotics for melioidosis treatment can be empirically used, but continuously monitoring antimicrobial susceptibility should be a concern.

Authors+Show Affiliations

Hanoi Medical University, Hanoi, Vietnam; Bach Mai Hospital, Hanoi, Vietnam. Electronic address: hongnhung@hmu.edu.vn.Hanoi Medical University, Hanoi, Vietnam.Bach Mai Hospital, Hanoi, Vietnam.Bach Mai Hospital, Hanoi, Vietnam.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30685463

Citation

Nhung, Pham Hong, et al. "Antimicrobial Susceptibility of Burkholderia Pseudomallei Isolates in Northern Vietnam." Journal of Global Antimicrobial Resistance, vol. 18, 2019, pp. 34-36.
Nhung PH, Van VH, Anh NQ, et al. Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam. J Glob Antimicrob Resist. 2019;18:34-36.
Nhung, P. H., Van, V. H., Anh, N. Q., & Phuong, D. M. (2019). Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam. Journal of Global Antimicrobial Resistance, 18, 34-36. https://doi.org/10.1016/j.jgar.2019.01.024
Nhung PH, et al. Antimicrobial Susceptibility of Burkholderia Pseudomallei Isolates in Northern Vietnam. J Glob Antimicrob Resist. 2019;18:34-36. PubMed PMID: 30685463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam. AU - Nhung,Pham Hong, AU - Van,Vu Ho, AU - Anh,Nguyen Quoc, AU - Phuong,Doan Mai, Y1 - 2019/01/24/ PY - 2018/07/12/received PY - 2019/01/06/revised PY - 2019/01/16/accepted PY - 2019/1/28/pubmed PY - 2020/6/17/medline PY - 2019/1/28/entrez KW - Antimicrobial susceptibility KW - Burkholderia pseudomallei KW - Melioidosis KW - Vietnam SP - 34 EP - 36 JF - Journal of global antimicrobial resistance JO - J Glob Antimicrob Resist VL - 18 N2 - OBJECTIVES: The antimicrobial susceptibility pattern of clinical Burkholderia pseudomallei (B. pseudomallei) in Vietnam has not been reported since the first publication in 2008. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary referral centre in Hanoi from January 2012 to December 2017. METHODS: A total of 312 B. pseudomallei isolates obtained from melioidosis patients admitted to a 2000-bed general hospital were analysed by the Etest method. Interpretation of the susceptibility testing results were reported using Clinical and Laboratory Standards Institute guidelines. RESULTS: All isolates were susceptible to ceftazidime, imipenem and amoxicillin-clavulanate (100%) with MIC90s relatively low (2μg/mL). Two isolates had intermediate resistance to doxycycline (0.6%) and 34 isolates were resistant to trimethoprim/sulfamethoxazole (10.9%). CONCLUSION: The results of this study suggest that currently recommended antibiotics for melioidosis treatment can be empirically used, but continuously monitoring antimicrobial susceptibility should be a concern. SN - 2213-7173 UR - https://www.unboundmedicine.com/medline/citation/30685463/Antimicrobial_susceptibility_of_Burkholderia_pseudomallei_isolates_in_Northern_Vietnam_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-7165(19)30031-1 DB - PRIME DP - Unbound Medicine ER -