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Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits.
Environ Sci Pollut Res Int. 2019 Mar; 26(8):8080-8086.ES

Abstract

The current study was performed to investigate the nephroprotective efficacy of Spirulina platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in protecting against amikacin (AMK)-induced nephrotoxicity in rabbits. Forty-two male New Zealand rabbits were allocated to seven equal groups, receiving (I) normal saline as negative controls, (II) oral SP (500 mg/kg body weight), (III) oral AA (20 mg/kg bw), (IV) intramuscular AMK injection (100 mg/kg bw), (V) AMK plus SP, (VI) AMK plus AA, or (VII) AMK plus SP and AA at the aforementioned doses. The treatments were given once/day for 7 days. Data analysis showed that in comparison to the control group, AMK-intoxicated rabbits showed significant increases (p ≤ 0.05) in serum concentrations of creatinine, uric acid, and urea, as well as renal tissue concentrations of tumor necrosis factor-α [TNF-α], malondialdehyde [MDA], and nitric oxide [NO]. Moreover, significant (p ≤ 0.05) reductions in renal glutathione concentration, antioxidant enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase), and total antioxidant capacity were noted following AMK intoxication. Treatment by SP ameliorated most of the aforementioned AMK-induced alterations. Although treatment with AA significantly reduced the renal tissue MDA, NO, and TNF-α concentrations, it was not associated with significant ameliorations of AMK-induced changes in the serum concentrations of renal function markers or renal tissue antioxidant parameters. The nephroprotective effects of SP-AA combination were more potent than SP alone in several parameters. In conclusion, SP alone or in combination with AA minimized the nephrotoxic effects of AMK through their antioxidant and anti-inflammatory activities.

Authors+Show Affiliations

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. abdeldaim.m@vet.suez.edu.eg.Department of Poultry and Rabbit Medicine, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.Faculty of Medicine, Ain Shams University, Ramsis St, 11566, Abbasia, Cairo, Egypt. Abdelrahman.abushouk@med.asu.edu.eg.Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.Faculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France.Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30685861

Citation

Abdel-Daim, Mohamed M., et al. "Influence of Spirulina Platensis and Ascorbic Acid On Amikacin-induced Nephrotoxicity in Rabbits." Environmental Science and Pollution Research International, vol. 26, no. 8, 2019, pp. 8080-8086.
Abdel-Daim MM, Ahmed A, Ijaz H, et al. Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits. Environ Sci Pollut Res Int. 2019;26(8):8080-8086.
Abdel-Daim, M. M., Ahmed, A., Ijaz, H., Abushouk, A. I., Ahmed, H., Negida, A., Aleya, L., & Bungau, S. G. (2019). Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits. Environmental Science and Pollution Research International, 26(8), 8080-8086. https://doi.org/10.1007/s11356-019-04249-4
Abdel-Daim MM, et al. Influence of Spirulina Platensis and Ascorbic Acid On Amikacin-induced Nephrotoxicity in Rabbits. Environ Sci Pollut Res Int. 2019;26(8):8080-8086. PubMed PMID: 30685861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits. AU - Abdel-Daim,Mohamed M, AU - Ahmed,Amira, AU - Ijaz,Hira, AU - Abushouk,Abdelrahman Ibrahim, AU - Ahmed,Hussien, AU - Negida,Ahmed, AU - Aleya,Lotfi, AU - Bungau,Simona G, Y1 - 2019/01/26/ PY - 2018/10/03/received PY - 2019/01/14/accepted PY - 2019/1/28/pubmed PY - 2019/5/11/medline PY - 2019/1/28/entrez KW - Amikacin KW - Ascorbic acid KW - Nephrotoxicity KW - Rabbit KW - Spirulina platensis SP - 8080 EP - 8086 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 8 N2 - The current study was performed to investigate the nephroprotective efficacy of Spirulina platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in protecting against amikacin (AMK)-induced nephrotoxicity in rabbits. Forty-two male New Zealand rabbits were allocated to seven equal groups, receiving (I) normal saline as negative controls, (II) oral SP (500 mg/kg body weight), (III) oral AA (20 mg/kg bw), (IV) intramuscular AMK injection (100 mg/kg bw), (V) AMK plus SP, (VI) AMK plus AA, or (VII) AMK plus SP and AA at the aforementioned doses. The treatments were given once/day for 7 days. Data analysis showed that in comparison to the control group, AMK-intoxicated rabbits showed significant increases (p ≤ 0.05) in serum concentrations of creatinine, uric acid, and urea, as well as renal tissue concentrations of tumor necrosis factor-α [TNF-α], malondialdehyde [MDA], and nitric oxide [NO]. Moreover, significant (p ≤ 0.05) reductions in renal glutathione concentration, antioxidant enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase), and total antioxidant capacity were noted following AMK intoxication. Treatment by SP ameliorated most of the aforementioned AMK-induced alterations. Although treatment with AA significantly reduced the renal tissue MDA, NO, and TNF-α concentrations, it was not associated with significant ameliorations of AMK-induced changes in the serum concentrations of renal function markers or renal tissue antioxidant parameters. The nephroprotective effects of SP-AA combination were more potent than SP alone in several parameters. In conclusion, SP alone or in combination with AA minimized the nephrotoxic effects of AMK through their antioxidant and anti-inflammatory activities. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/30685861/Influence_of_Spirulina_platensis_and_ascorbic_acid_on_amikacin_induced_nephrotoxicity_in_rabbits_ DB - PRIME DP - Unbound Medicine ER -