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Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry.
Photodermatol. 1988 Aug; 5(4):187-95.P

Abstract

The effect of single doses of ultraviolet (UV) radiation was studied in 6 healthy men of skin Type III. Test areas on the forearm were irradiated with 150 J/cm2 UVA, 0.5 MED, 1 MED, and 3 MED UVB, and 1 MED UVC. Test areas and control areas were followed up for 1 month by clinical assessment, laser-Doppler flowmetry, evaporimetry, and optothermal infrared spectrometry (OTIS). UVA produced immediate erythema; the reaction appeared later with the other wavelength regions. All responses peaked after 12-24 h. The degree of erythema of UV-induced inflammation assessed visually correlated closely with the increase in skin blood flow registered with the laser-Doppler flowmeter. No increase in transepidermal water loss, indicating damage to the epidermal barrier, could be recorded by evaporimetry except on the area irradiated with 3 MED of UVB, where 4 subjects showed a moderate increase after 2 weeks. Changes in water content in the uppermost part of the epidermis, mainly in the stratum corneum, were detected by OTIS. A decrease took place that was most pronounced in the area irradiated with 3 MED UVB. This decrease in the OTIS signal is probably due to a combination of increased thickness and decreased water content of stratum corneum. We believe that these 3 noninvasive methods, especially in combination, are useful in the evaluation of different aspects of UV reactions.

Authors+Show Affiliations

Department of Dermatology, University Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3068642

Citation

Frödin, T, et al. "Effects of Single Doses of UVA, UVB, and UVC On Skin Blood Flow, Water Content, and Barrier Function Measured By laser-Doppler Flowmetry, Optothermal Infrared Spectrometry, and Evaporimetry." Photo-dermatology, vol. 5, no. 4, 1988, pp. 187-95.
Frödin T, Molin L, Skogh M. Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry. Photodermatol. 1988;5(4):187-95.
Frödin, T., Molin, L., & Skogh, M. (1988). Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry. Photo-dermatology, 5(4), 187-95.
Frödin T, Molin L, Skogh M. Effects of Single Doses of UVA, UVB, and UVC On Skin Blood Flow, Water Content, and Barrier Function Measured By laser-Doppler Flowmetry, Optothermal Infrared Spectrometry, and Evaporimetry. Photodermatol. 1988;5(4):187-95. PubMed PMID: 3068642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of single doses of UVA, UVB, and UVC on skin blood flow, water content, and barrier function measured by laser-Doppler flowmetry, optothermal infrared spectrometry, and evaporimetry. AU - Frödin,T, AU - Molin,L, AU - Skogh,M, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 187 EP - 95 JF - Photo-dermatology JO - Photodermatol VL - 5 IS - 4 N2 - The effect of single doses of ultraviolet (UV) radiation was studied in 6 healthy men of skin Type III. Test areas on the forearm were irradiated with 150 J/cm2 UVA, 0.5 MED, 1 MED, and 3 MED UVB, and 1 MED UVC. Test areas and control areas were followed up for 1 month by clinical assessment, laser-Doppler flowmetry, evaporimetry, and optothermal infrared spectrometry (OTIS). UVA produced immediate erythema; the reaction appeared later with the other wavelength regions. All responses peaked after 12-24 h. The degree of erythema of UV-induced inflammation assessed visually correlated closely with the increase in skin blood flow registered with the laser-Doppler flowmeter. No increase in transepidermal water loss, indicating damage to the epidermal barrier, could be recorded by evaporimetry except on the area irradiated with 3 MED of UVB, where 4 subjects showed a moderate increase after 2 weeks. Changes in water content in the uppermost part of the epidermis, mainly in the stratum corneum, were detected by OTIS. A decrease took place that was most pronounced in the area irradiated with 3 MED UVB. This decrease in the OTIS signal is probably due to a combination of increased thickness and decreased water content of stratum corneum. We believe that these 3 noninvasive methods, especially in combination, are useful in the evaluation of different aspects of UV reactions. SN - 0108-9684 UR - https://www.unboundmedicine.com/medline/citation/3068642/Effects_of_single_doses_of_UVA_UVB_and_UVC_on_skin_blood_flow_water_content_and_barrier_function_measured_by_laser_Doppler_flowmetry_optothermal_infrared_spectrometry_and_evaporimetry_ DB - PRIME DP - Unbound Medicine ER -