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Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract.
Planta Med 2019; 85(7):608-614PM

Abstract

The anti-inflammatory properties of the topical herbal composition VEL-091604 with gentian root, licorice root, and willow bark extract were assessed in a randomized, prospective, placebo-controlled, double-blind ultraviolet (UV)-erythema test study with 42 healthy volunteers in comparison to 1% hydrocortisone acetate. The efficacy and tolerability of VEL-091604 cream 2 times daily over 2 wk was evaluated in an open-label, prospective proof of concept study in 10 subjects with atopic dermatitis using a lesional SCORAD severity score. In the UV-erythema test VEL-091604 cream significantly reduced inflammation compared to placebo and was as effective as 1% hydrocortisone acetate. The clinical study with atopic subjects revealed a significant and rapid reduction of the lesional SCORAD severity score in the test areas after 1 and 2 wk. No adverse events were recorded. It is concluded that the herbal cream VEL-091604 with licorice root, willow bark, and gentian root extract display anti-inflammatory properties in vivo. It is a promising new treatment option for atopic dermatitis that warrants further investigation in controlled studies.

Authors+Show Affiliations

Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.BSI Beauty Science Intelligence GmbH, Langenhagen, Germany.Flavex Naturextrakte GmbH, Rehlingen, Germany.Research Center skinitial, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30690691

Citation

Seiwerth, Jasmin, et al. "Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract." Planta Medica, vol. 85, no. 7, 2019, pp. 608-614.
Seiwerth J, Tasiopoulou G, Hoffmann J, et al. Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. Planta Med. 2019;85(7):608-614.
Seiwerth, J., Tasiopoulou, G., Hoffmann, J., Wölfle, U., Schwabe, K., Quirin, K. W., & Schempp, C. M. (2019). Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. Planta Medica, 85(7), pp. 608-614. doi:10.1055/a-0835-6806.
Seiwerth J, et al. Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. Planta Med. 2019;85(7):608-614. PubMed PMID: 30690691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract. AU - Seiwerth,Jasmin, AU - Tasiopoulou,Georgia, AU - Hoffmann,Julia, AU - Wölfle,Ute, AU - Schwabe,Kay, AU - Quirin,Karl-Werner, AU - Schempp,Christoph Mathis, Y1 - 2019/01/28/ PY - 2019/1/29/pubmed PY - 2019/6/14/medline PY - 2019/1/29/entrez SP - 608 EP - 614 JF - Planta medica JO - Planta Med. VL - 85 IS - 7 N2 - The anti-inflammatory properties of the topical herbal composition VEL-091604 with gentian root, licorice root, and willow bark extract were assessed in a randomized, prospective, placebo-controlled, double-blind ultraviolet (UV)-erythema test study with 42 healthy volunteers in comparison to 1% hydrocortisone acetate. The efficacy and tolerability of VEL-091604 cream 2 times daily over 2 wk was evaluated in an open-label, prospective proof of concept study in 10 subjects with atopic dermatitis using a lesional SCORAD severity score. In the UV-erythema test VEL-091604 cream significantly reduced inflammation compared to placebo and was as effective as 1% hydrocortisone acetate. The clinical study with atopic subjects revealed a significant and rapid reduction of the lesional SCORAD severity score in the test areas after 1 and 2 wk. No adverse events were recorded. It is concluded that the herbal cream VEL-091604 with licorice root, willow bark, and gentian root extract display anti-inflammatory properties in vivo. It is a promising new treatment option for atopic dermatitis that warrants further investigation in controlled studies. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/30690691/Anti-Inflammatory_Effect_of_a_Novel_Topical_Herbal_Composition_(VEL-091604)_Consisting_of_Gentian_Root,_Licorice_Root_and_Willow_Bark_Extract L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0835-6806 DB - PRIME DP - Unbound Medicine ER -