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Ethics of Human Genome Editing.
Annu Rev Med. 2019 01 27; 70:289-305.AR

Abstract

Advances in human genome editing, in particular the development of the clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 method, have led to increasing concerns about the ethics of editing the human genome. In response, the US National Academy of Sciences and the National Academy of Medicine constituted a multidisciplinary, international committee to review the current status and make recommendations. I was a member of that committee, and the core of this review reflects the committee's conclusions. The committee's report, issued in February 2017, recommends the application of current ethical and regulatory standards for gene therapy to somatic (nonheritable) human genome editing. It also recommends allowing experimental germline genome editing to proceed if (a) it is restricted to preventing transmission of a serious disease or condition, (b) the edit is a modification to a common DNA sequence known not to be associated with disease, and (c) the research is conducted under a stringent set of ethical and regulatory requirements. Crossing the so-called red line of germline genome editing raises important bioethical issues, most importantly, serious concern about the potential negative impact on individuals with disabilities. This review highlights some of the major ethical considerations in human genome editing in light of the report's recommendations.

Authors+Show Affiliations

Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA; email: collerb@rockefeller.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

30691366

Citation

Coller, Barry S.. "Ethics of Human Genome Editing." Annual Review of Medicine, vol. 70, 2019, pp. 289-305.
Coller BS. Ethics of Human Genome Editing. Annu Rev Med. 2019;70:289-305.
Coller, B. S. (2019). Ethics of Human Genome Editing. Annual Review of Medicine, 70, 289-305. https://doi.org/10.1146/annurev-med-112717-094629
Coller BS. Ethics of Human Genome Editing. Annu Rev Med. 2019 01 27;70:289-305. PubMed PMID: 30691366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethics of Human Genome Editing. A1 - Coller,Barry S, PY - 2019/1/30/entrez PY - 2019/1/30/pubmed PY - 2019/1/30/medline KW - disability KW - genetic KW - germline (heritable) human genome editing KW - human genome editing KW - mutation KW - somatic (nonheritable) human genome editing SP - 289 EP - 305 JF - Annual review of medicine JO - Annu. Rev. Med. VL - 70 N2 - Advances in human genome editing, in particular the development of the clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 method, have led to increasing concerns about the ethics of editing the human genome. In response, the US National Academy of Sciences and the National Academy of Medicine constituted a multidisciplinary, international committee to review the current status and make recommendations. I was a member of that committee, and the core of this review reflects the committee's conclusions. The committee's report, issued in February 2017, recommends the application of current ethical and regulatory standards for gene therapy to somatic (nonheritable) human genome editing. It also recommends allowing experimental germline genome editing to proceed if (a) it is restricted to preventing transmission of a serious disease or condition, (b) the edit is a modification to a common DNA sequence known not to be associated with disease, and (c) the research is conducted under a stringent set of ethical and regulatory requirements. Crossing the so-called red line of germline genome editing raises important bioethical issues, most importantly, serious concern about the potential negative impact on individuals with disabilities. This review highlights some of the major ethical considerations in human genome editing in light of the report's recommendations. SN - 1545-326X UR - https://www.unboundmedicine.com/medline/citation/30691366/Ethics_of_Human_Genome_Editing_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-med-112717-094629?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -