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Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease.
Clin Chest Med 1988; 9(4):551-6CC

Abstract

Bronchiolitis obliterans is a nonspecific pathologic lesion seen after fume inhalation and infections, which is associated with connective tissue disorders and is a complication of organ transplantation. Bronchiolitis obliterans with organizing pneumonia is also associated with the connective tissue disorders but is usually idiopathic and has better prognosis with corticosteroid therapy. Bone marrow-related obliterative bronchiolitis is limited to patients who develop chronic graft-versus-host disease. Symptoms begin with cough in 3 to 6 months and progress to dyspnea and severe airflow obstruction. The roentgenogram is normal or shows hyperinflation. Prognosis is poor and most patients develop disabling irreversible airflow obstruction. Bronchiolitis obliterans is the most important clinical complication in heart-lung transplant recipients. It is not preceded by typical features of chronic graft-versus-host disease, but has the same clinical course of dyspnea, airflow obstruction, and poor response to therapy. Bronchiolitis obliterans in transplant recipients may represent a form of allograft rejection.

Authors+Show Affiliations

Boston University School of Medicine, Massachusetts.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3069287

Citation

Epler, G R.. "Bronchiolitis Obliterans and Airways Obstruction Associated With Graft-versus-host Disease." Clinics in Chest Medicine, vol. 9, no. 4, 1988, pp. 551-6.
Epler GR. Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease. Clin Chest Med. 1988;9(4):551-6.
Epler, G. R. (1988). Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease. Clinics in Chest Medicine, 9(4), pp. 551-6.
Epler GR. Bronchiolitis Obliterans and Airways Obstruction Associated With Graft-versus-host Disease. Clin Chest Med. 1988;9(4):551-6. PubMed PMID: 3069287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease. A1 - Epler,G R, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 551 EP - 6 JF - Clinics in chest medicine JO - Clin. Chest Med. VL - 9 IS - 4 N2 - Bronchiolitis obliterans is a nonspecific pathologic lesion seen after fume inhalation and infections, which is associated with connective tissue disorders and is a complication of organ transplantation. Bronchiolitis obliterans with organizing pneumonia is also associated with the connective tissue disorders but is usually idiopathic and has better prognosis with corticosteroid therapy. Bone marrow-related obliterative bronchiolitis is limited to patients who develop chronic graft-versus-host disease. Symptoms begin with cough in 3 to 6 months and progress to dyspnea and severe airflow obstruction. The roentgenogram is normal or shows hyperinflation. Prognosis is poor and most patients develop disabling irreversible airflow obstruction. Bronchiolitis obliterans is the most important clinical complication in heart-lung transplant recipients. It is not preceded by typical features of chronic graft-versus-host disease, but has the same clinical course of dyspnea, airflow obstruction, and poor response to therapy. Bronchiolitis obliterans in transplant recipients may represent a form of allograft rejection. SN - 0272-5231 UR - https://www.unboundmedicine.com/medline/citation/3069287/Bronchiolitis_obliterans_and_airways_obstruction_associated_with_graft_versus_host_disease_ L2 - http://www.diseaseinfosearch.org/result/971 DB - PRIME DP - Unbound Medicine ER -