TY - JOUR T1 - [The pharmacokinetic and toxicologic profile of 8-methoxypsoralen. The basis for safe and effective PUVA therapy]. AU - Schmid,J, AU - Brickl,R, AU - Koss,F W, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 177 EP - 85 JF - Dermatosen in Beruf und Umwelt. Occupation and environment JO - Derm Beruf Umwelt VL - 36 IS - 6 N2 - On the basis of approximately 60 publications and in view of our own results we present a comprehensive review as to the mode of action, the pharmacokinetics, the metabolism and the toxicology of 8-methoxypsoralen (8-MOP) and its consequences in the PUVA therapy of psoriasis. The interaction of 8-MOP with DNA is presently considered to be the most likely mode of action. 8-MOP is subject to strong first-pass effects with considerable individual variations in plasma levels. An exact timing of drug dose and light dose is essential for a successful therapy, simultaneously minimizing the potential short-term and long-term risks of PUVA therapy. SN - 0343-2432 UR - https://www.unboundmedicine.com/medline/citation/3069432/[The_pharmacokinetic_and_toxicologic_profile_of_8_methoxypsoralen__The_basis_for_safe_and_effective_PUVA_therapy]_ DB - PRIME DP - Unbound Medicine ER -