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[The pharmacokinetic and toxicologic profile of 8-methoxypsoralen. The basis for safe and effective PUVA therapy].
Derm Beruf Umwelt. 1988 Nov-Dec; 36(6):177-85.DB

Abstract

On the basis of approximately 60 publications and in view of our own results we present a comprehensive review as to the mode of action, the pharmacokinetics, the metabolism and the toxicology of 8-methoxypsoralen (8-MOP) and its consequences in the PUVA therapy of psoriasis. The interaction of 8-MOP with DNA is presently considered to be the most likely mode of action. 8-MOP is subject to strong first-pass effects with considerable individual variations in plasma levels. An exact timing of drug dose and light dose is essential for a successful therapy, simultaneously minimizing the potential short-term and long-term risks of PUVA therapy.

Authors+Show Affiliations

Abteilung Biochemie der Dr. Karl Thomae GmbH, Biberach an der Riss.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

3069432

Citation

Schmid, J, et al. "[The Pharmacokinetic and Toxicologic Profile of 8-methoxypsoralen. the Basis for Safe and Effective PUVA Therapy]." Dermatosen in Beruf Und Umwelt. Occupation and Environment, vol. 36, no. 6, 1988, pp. 177-85.
Schmid J, Brickl R, Koss FW. [The pharmacokinetic and toxicologic profile of 8-methoxypsoralen. The basis for safe and effective PUVA therapy]. Derm Beruf Umwelt. 1988;36(6):177-85.
Schmid, J., Brickl, R., & Koss, F. W. (1988). [The pharmacokinetic and toxicologic profile of 8-methoxypsoralen. The basis for safe and effective PUVA therapy]. Dermatosen in Beruf Und Umwelt. Occupation and Environment, 36(6), 177-85.
Schmid J, Brickl R, Koss FW. [The Pharmacokinetic and Toxicologic Profile of 8-methoxypsoralen. the Basis for Safe and Effective PUVA Therapy]. Derm Beruf Umwelt. 1988 Nov-Dec;36(6):177-85. PubMed PMID: 3069432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The pharmacokinetic and toxicologic profile of 8-methoxypsoralen. The basis for safe and effective PUVA therapy]. AU - Schmid,J, AU - Brickl,R, AU - Koss,F W, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 177 EP - 85 JF - Dermatosen in Beruf und Umwelt. Occupation and environment JO - Derm Beruf Umwelt VL - 36 IS - 6 N2 - On the basis of approximately 60 publications and in view of our own results we present a comprehensive review as to the mode of action, the pharmacokinetics, the metabolism and the toxicology of 8-methoxypsoralen (8-MOP) and its consequences in the PUVA therapy of psoriasis. The interaction of 8-MOP with DNA is presently considered to be the most likely mode of action. 8-MOP is subject to strong first-pass effects with considerable individual variations in plasma levels. An exact timing of drug dose and light dose is essential for a successful therapy, simultaneously minimizing the potential short-term and long-term risks of PUVA therapy. SN - 0343-2432 UR - https://www.unboundmedicine.com/medline/citation/3069432/[The_pharmacokinetic_and_toxicologic_profile_of_8_methoxypsoralen__The_basis_for_safe_and_effective_PUVA_therapy]_ DB - PRIME DP - Unbound Medicine ER -
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