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Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study.
Nutrients 2019; 11(2)N

Abstract

Dairy products are important constituents of most diets, and their association with adverse health outcomes remains a focus. We characterized dairy food intake and examined associations with the incidence of type 2 diabetes (T2D), myocardial infarction (MI) or stroke among 108,065 Swedish men and women. Hazard ratios (HRs) and 95% CIs were estimated using the multivariable Cox proportional hazards models in a population characterized by high milk tolerance. During a mean follow-up of 14.2 years, 11,641 first-time events occurred. Non-fermented milk intake decreased, whereas butter intake increased over the period. For high intake of non-fermented milk, the HR (95% CI) for developing T2D and MI was 1.17 (1.03, 1.34) and 1.23 (1.10, 1.37), respectively, in men. A greater intake of butter, fermented milk, and cheese tended to be associated with a reduced risk of T2D and/or MI. Non-consumers and those who chose low-fat variants of the targeted dairy products had increased risk for T2D, MI, or stroke compared to those in the non-case group. Generally, effect-sizes were small. This prospective study found that non-fermented milk was associated with an increased risk for developing T2D and MI and that subjects abstaining from dairy products or choosing low-fat variants were at greater risk. However, the overall cardiometabolic risk of non-fermented milk intake was judged as low, since the effect sizes were small.

Authors+Show Affiliations

Department of Odontology, Umeå University, 90187 Umeå, Sweden. ingegerd.johansson@umu.se.Department of Odontology, Umeå University, 90187 Umeå, Sweden. anders.esberg@umu.se.Department of Nutritional Research, Umeå University, 90187 Umeå, Sweden. lena.nilsson@umu.se.Department of Public Health and Clinical Medicine, Research Unit Skellefteå, Umeå University, 90187 Umeå, Sweden. janhakan.jansson@vll.se.Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, 90187 Umeå, Sweden. anna.winkvist@nutrition.gu.se.Department of Nutritional Research, Umeå University, 90187 Umeå, Sweden. janhakan.jansson@vll.se. Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. janhakan.jansson@vll.se.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30696081

Citation

Johansson, Ingegerd, et al. "Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: a 33-Year Prospective Cohort Study." Nutrients, vol. 11, no. 2, 2019.
Johansson I, Esberg A, Nilsson LM, et al. Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study. Nutrients. 2019;11(2).
Johansson, I., Esberg, A., Nilsson, L. M., Jansson, J. H., Wennberg, P., & Winkvist, A. (2019). Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study. Nutrients, 11(2), doi:10.3390/nu11020284.
Johansson I, et al. Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: a 33-Year Prospective Cohort Study. Nutrients. 2019 Jan 28;11(2) PubMed PMID: 30696081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study. AU - Johansson,Ingegerd, AU - Esberg,Anders, AU - Nilsson,Lena M, AU - Jansson,Jan-Håkan, AU - Wennberg,Patrik, AU - Winkvist,Anna, Y1 - 2019/01/28/ PY - 2018/12/14/received PY - 2019/01/24/revised PY - 2019/01/24/accepted PY - 2019/1/31/entrez PY - 2019/1/31/pubmed PY - 2019/4/4/medline KW - cardiovascular disease KW - dairy products KW - milk KW - myocardial infarction KW - stroke KW - type 2 diabetes JF - Nutrients JO - Nutrients VL - 11 IS - 2 N2 - Dairy products are important constituents of most diets, and their association with adverse health outcomes remains a focus. We characterized dairy food intake and examined associations with the incidence of type 2 diabetes (T2D), myocardial infarction (MI) or stroke among 108,065 Swedish men and women. Hazard ratios (HRs) and 95% CIs were estimated using the multivariable Cox proportional hazards models in a population characterized by high milk tolerance. During a mean follow-up of 14.2 years, 11,641 first-time events occurred. Non-fermented milk intake decreased, whereas butter intake increased over the period. For high intake of non-fermented milk, the HR (95% CI) for developing T2D and MI was 1.17 (1.03, 1.34) and 1.23 (1.10, 1.37), respectively, in men. A greater intake of butter, fermented milk, and cheese tended to be associated with a reduced risk of T2D and/or MI. Non-consumers and those who chose low-fat variants of the targeted dairy products had increased risk for T2D, MI, or stroke compared to those in the non-case group. Generally, effect-sizes were small. This prospective study found that non-fermented milk was associated with an increased risk for developing T2D and MI and that subjects abstaining from dairy products or choosing low-fat variants were at greater risk. However, the overall cardiometabolic risk of non-fermented milk intake was judged as low, since the effect sizes were small. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30696081/Dairy_Product_Intake_and_Cardiometabolic_Diseases_in_Northern_Sweden:_A_33_Year_Prospective_Cohort_Study_ L2 - http://www.mdpi.com/resolver?pii=nu11020284 DB - PRIME DP - Unbound Medicine ER -