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Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial.
Trials. 2019 Jan 29; 20(1):88.T

Abstract

BACKGROUND

Older adults with Mild Cognitive Impairment (MCI) are at high risk of progressing to Alzheimer's disease (AD). Slowing down the effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback (NF) has shown promising results in improving working memory but has never been evaluated in people with MCI. We aim to examine whether NF training can decrease cognitive disorders, targeting memory, attention functions and brain electrical activity in elderly patients with MCI.

METHODS

In this single-blind, randomized controlled trial (RCT) protocol, we will investigate the effects of two NF training protocols on cognitive performances and on brain electrical activity. Sixty MCI patients will be assigned either to an intervention program or to psycho-pedagogical care as a control condition. Participants in the intervention group will attend 30 sessions of sensorimotor/delta-ratio NF training or beta1/theta-ratio NF training. Neuropsychological assessment, questionnaires and electroencephalography (EEG) assessment parameters will be used as dependent variables in three periods: at baseline (T0), immediately after the last NF training session at 4 months (T1) and at 3-month follow-up (T2). The primary outcome will be the change in attention measured with the Trail Making Test B. Secondary outcome will be the changes in cognitive performance and in EEG activities.

DISCUSSION

If the results of our study show improvement in cognitive performances of older adults with MCI, this non-invasive, low-cost technique may deserve better consideration as a therapeutic intervention to delay cognitive decline and dementia. Consequently, research in NF will need to review and develop the rigor of its application in gerontology.

TRIAL REGISTRATION

ClinicalTrials.gov, ID: NCT03526692 . Registered on 16 May 2018.

Authors+Show Affiliations

Department of Clinical Gerontology, Broca Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Research TEAM EA4468, Paris Descartes University, Paris, France. fabiennemarlats@gmail.com.Department of Clinical Gerontology, Broca Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Research TEAM EA4468, Paris Descartes University, Paris, France.Clinical Neurophysiology Laboratory, Department of Physiology, Raymond Poincaré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U1173, University of Versailles Saint Quentin en Yvelines, Garches, France.Clinical Research Unit, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris AP-HP, Bobigny, France.Department of Surgery, Franciscus Gasthuis and Vlietland, Rotterdam/Schiedam, The Netherlands.Department of Clinical Gerontology, Broca Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Research TEAM EA4468, Paris Descartes University, Paris, France.

Pub Type(s)

Clinical Trial Protocol
Journal Article

Language

eng

PubMed ID

30696475

Citation

Marlats, Fabienne, et al. "Comparison of Effects Between SMR/delta-ratio and Beta1/theta-ratio Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol for a Randomized Controlled Trial." Trials, vol. 20, no. 1, 2019, p. 88.
Marlats F, Djabelkhir-Jemmi L, Azabou E, et al. Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial. Trials. 2019;20(1):88.
Marlats, F., Djabelkhir-Jemmi, L., Azabou, E., Boubaya, M., Pouwels, S., & Rigaud, A. S. (2019). Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial. Trials, 20(1), 88. https://doi.org/10.1186/s13063-018-3170-x
Marlats F, et al. Comparison of Effects Between SMR/delta-ratio and Beta1/theta-ratio Neurofeedback Training for Older Adults With Mild Cognitive Impairment: a Protocol for a Randomized Controlled Trial. Trials. 2019 Jan 29;20(1):88. PubMed PMID: 30696475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial. AU - Marlats,Fabienne, AU - Djabelkhir-Jemmi,Leila, AU - Azabou,Eric, AU - Boubaya,Marouane, AU - Pouwels,Sjaak, AU - Rigaud,Anne-Sophie, Y1 - 2019/01/29/ PY - 2018/6/8/received PY - 2018/12/30/accepted PY - 2019/1/31/entrez PY - 2019/1/31/pubmed PY - 2019/5/29/medline KW - Alzheimer KW - Attention KW - Electroencephalography KW - Memory KW - Mild Cognitive Impairment KW - Neurofeedback SP - 88 EP - 88 JF - Trials JO - Trials VL - 20 IS - 1 N2 - BACKGROUND: Older adults with Mild Cognitive Impairment (MCI) are at high risk of progressing to Alzheimer's disease (AD). Slowing down the effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback (NF) has shown promising results in improving working memory but has never been evaluated in people with MCI. We aim to examine whether NF training can decrease cognitive disorders, targeting memory, attention functions and brain electrical activity in elderly patients with MCI. METHODS: In this single-blind, randomized controlled trial (RCT) protocol, we will investigate the effects of two NF training protocols on cognitive performances and on brain electrical activity. Sixty MCI patients will be assigned either to an intervention program or to psycho-pedagogical care as a control condition. Participants in the intervention group will attend 30 sessions of sensorimotor/delta-ratio NF training or beta1/theta-ratio NF training. Neuropsychological assessment, questionnaires and electroencephalography (EEG) assessment parameters will be used as dependent variables in three periods: at baseline (T0), immediately after the last NF training session at 4 months (T1) and at 3-month follow-up (T2). The primary outcome will be the change in attention measured with the Trail Making Test B. Secondary outcome will be the changes in cognitive performance and in EEG activities. DISCUSSION: If the results of our study show improvement in cognitive performances of older adults with MCI, this non-invasive, low-cost technique may deserve better consideration as a therapeutic intervention to delay cognitive decline and dementia. Consequently, research in NF will need to review and develop the rigor of its application in gerontology. TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT03526692 . Registered on 16 May 2018. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/30696475/Comparison_of_effects_between_SMR/delta_ratio_and_beta1/theta_ratio_neurofeedback_training_for_older_adults_with_Mild_Cognitive_Impairment:_a_protocol_for_a_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -