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A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations.
Arch Med Sci. 2019 Jan; 15(1):12-22.AM

Abstract

Introduction

Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs).

Material and methods

The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1st February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Meta-analysis was performed using a random-effects model, and effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).

Results

Meta-analysis of 17 selected RCTs with 1256 individuals did not suggest a significant change in plasma CRP concentrations following supplementation with flaxseed-containing products (WMD: -0.25 mg/l, 95% CI: -0.53, 0.02, p = 0.074). The effect size was robust in the leave-one-out sensitivity analysis. Subgroup analysis did not suggest any significant difference in terms of changing plasma CRP concentrations among different types of flaxseed supplements used in the included studies, i.e. flaxseed oil (WMD: -0.67 mg/l, 95% CI: -2.00, 0.65, p = 0.320), lignan extract (WMD: -0.32 mg/l, 95% CI: -0.71, 0.06, p = 0.103) and ground powder (WMD: -0.18 mg/l, 95% CI: -0.42, 0.06, p = 0.142).

Conclusions

The meta-analysis of RCTs did not show a significant change in plasma CRP concentrations following supplementation with various flaxseed products. Large, well-designed studies should be still performed to validate the current results.

Authors+Show Affiliations

Department of Functional Sciences, Discipline of Public Health, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.Biotechnology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.Department 2, Discipline of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30697250

Citation

Ursoniu, Sorin, et al. "A Systematic Review and Meta-analysis of Clinical Trials Investigating the Effects of Flaxseed Supplementation On Plasma C-reactive Protein Concentrations." Archives of Medical Science : AMS, vol. 15, no. 1, 2019, pp. 12-22.
Ursoniu S, Sahebkar A, Serban MC, et al. A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations. Arch Med Sci. 2019;15(1):12-22.
Ursoniu, S., Sahebkar, A., Serban, M. C., Pinzaru, I., Dehelean, C., Noveanu, L., Rysz, J., & Banach, M. (2019). A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations. Archives of Medical Science : AMS, 15(1), 12-22. https://doi.org/10.5114/aoms.2018.81034
Ursoniu S, et al. A Systematic Review and Meta-analysis of Clinical Trials Investigating the Effects of Flaxseed Supplementation On Plasma C-reactive Protein Concentrations. Arch Med Sci. 2019;15(1):12-22. PubMed PMID: 30697250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations. AU - Ursoniu,Sorin, AU - Sahebkar,Amirhossein, AU - Serban,Maria-Corina, AU - Pinzaru,Iulia, AU - Dehelean,Cristina, AU - Noveanu,Lavinia, AU - Rysz,Jacek, AU - Banach,Maciej, AU - ,, Y1 - 2018/12/30/ PY - 2017/05/16/received PY - 2017/05/28/accepted PY - 2019/1/31/entrez PY - 2019/1/31/pubmed PY - 2019/1/31/medline KW - C-reactive protein KW - Linum usitatissimum KW - flaxseed KW - linseed KW - meta-analysis KW - systematic review SP - 12 EP - 22 JF - Archives of medical science : AMS JO - Arch Med Sci VL - 15 IS - 1 N2 - Introduction: Many experimental and clinical trials have suggested that flaxseed might be a potent antihypertensive, but the evidence concerning the effects of flaxseed supplements on plasma C-reactive protein (CRP) concentrations has not been fully conclusive. We assessed the impact of the effects of flaxseed supplementation on plasma CRP concentrations through a systematic review of literature and meta-analysis of available randomised controlled trials (RCTs). Material and methods: The literature search included EMBASE, ProQuest, CINAHL, and PUBMED databases up to 1st February 2016 to identify RCTs investigating the effect of flaxseed supplements on plasma CRP concentrations. Meta-analysis was performed using a random-effects model, and effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI). Results: Meta-analysis of 17 selected RCTs with 1256 individuals did not suggest a significant change in plasma CRP concentrations following supplementation with flaxseed-containing products (WMD: -0.25 mg/l, 95% CI: -0.53, 0.02, p = 0.074). The effect size was robust in the leave-one-out sensitivity analysis. Subgroup analysis did not suggest any significant difference in terms of changing plasma CRP concentrations among different types of flaxseed supplements used in the included studies, i.e. flaxseed oil (WMD: -0.67 mg/l, 95% CI: -2.00, 0.65, p = 0.320), lignan extract (WMD: -0.32 mg/l, 95% CI: -0.71, 0.06, p = 0.103) and ground powder (WMD: -0.18 mg/l, 95% CI: -0.42, 0.06, p = 0.142). Conclusions: The meta-analysis of RCTs did not show a significant change in plasma CRP concentrations following supplementation with various flaxseed products. Large, well-designed studies should be still performed to validate the current results. SN - 1734-1922 UR - https://www.unboundmedicine.com/medline/citation/30697250/A_systematic_review_and_meta_analysis_of_clinical_trials_investigating_the_effects_of_flaxseed_supplementation_on_plasma_C_reactive_protein_concentrations_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30697250/ DB - PRIME DP - Unbound Medicine ER -
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