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Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease.
Ter Arkh. 2018 Sep 20; 90(9):60-67.TA

Abstract

AIM

To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients with chronic kidney disease (CKD).

MATERIALS AND METHODS

The study included 225 patients with stage I-CKD of non-diabetic etiology (median age 47.0 years, 50.2% of women). Depending on the degree of decrease in the glomerular filtration rate (GFR), all patients were divided into 3 groups. Group 1 (n=70) consisted of patients with GFR 89-45 ml / min / 1.73 m2, group 2 (n=120) - patients with GFR 44-15 ml / min / 1.73 m2, group 3 (n=35) - patients with GFR <15 mL / min / 1.73 m2. The control group includes persons without CKD. All patients underwent general clinical examination and transthoracic echocardiography; in 86 patients the level of cystatin C in the blood serum was determined.

RESULTS

Hypertrophy of the left ventricle (LVH) of the heart was detected in 87 (38.7%) of 225 patients with CKD. Hypertrophic type (type I) of myocardial DD is diagnosed in 90 (41.4%) of 225 patients with CKD. The incidence of myocardial left ventricular dysfunction of the 1st type increased with a decrease in GFR, amounting to 30, 40 and 60% in groups 1, 2 and 3, respectively. The systolic function of the left ventricular myocardium was preserved. Patients with DD were older, they had a higher body mass index (BMI), a more pronounced decrease in GFR, a higher level of fibrinogen. They were more likely to have LVH. The level of cystatin C as the kidney function worsened, but when comparing the mean levels of cystatin C in patients with the presence / absence of DD in the groups isolated depending on the stage of CKD, no statistically significant differences were found. According to the multivariate analysis, the independent predictor of DD was the age (odds ratio 1.106, 95% confidence interval 1.051-1.157, p=0.00001).

CONCLUSION

DD of the myocardium of the LV is detected on average in 40% of patients with CKD, the frequency of its development increases with the progression of renal dysfunction. The development of DD is influenced by traditional factors of cardiovascular risk (age, BMI), as well as the decline in GFR and closely related structural remodeling of LV myocardium.

Authors+Show Affiliations

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. M.V. Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, Russia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30701737

Citation

Rudenko, T E., et al. "Risk Factors for Diastolic Left Ventricular Myocardial Dysfunction in Patients With Chronic Kidney Disease." Terapevticheskii Arkhiv, vol. 90, no. 9, 2018, pp. 60-67.
Rudenko TE, Kamyshova ES, Vasilyeva MP, et al. Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease. Ter Arkh. 2018;90(9):60-67.
Rudenko, T. E., Kamyshova, E. S., Vasilyeva, M. P., Bobkova, I. N., Solomakhina, N. I., & Shvetsov, M. Y. (2018). Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease. Terapevticheskii Arkhiv, 90(9), 60-67. https://doi.org/10.26442/terarkh201890960-67
Rudenko TE, et al. Risk Factors for Diastolic Left Ventricular Myocardial Dysfunction in Patients With Chronic Kidney Disease. Ter Arkh. 2018 Sep 20;90(9):60-67. PubMed PMID: 30701737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for diastolic left ventricular myocardial dysfunction in patients with chronic kidney disease. AU - Rudenko,T E, AU - Kamyshova,E S, AU - Vasilyeva,M P, AU - Bobkova,I N, AU - Solomakhina,N I, AU - Shvetsov,M Y, PY - 2019/2/1/entrez PY - 2019/2/1/pubmed PY - 2019/3/1/medline KW - chronic kidney disease KW - diastolic left ventricular myocardium dysfunction SP - 60 EP - 67 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 90 IS - 9 N2 - AIM: To examine the frequency and risk factors for the development of diastolic dysfunction (DD) of the left ventricle (LV) of the heart in patients with chronic kidney disease (CKD). MATERIALS AND METHODS: The study included 225 patients with stage I-CKD of non-diabetic etiology (median age 47.0 years, 50.2% of women). Depending on the degree of decrease in the glomerular filtration rate (GFR), all patients were divided into 3 groups. Group 1 (n=70) consisted of patients with GFR 89-45 ml / min / 1.73 m2, group 2 (n=120) - patients with GFR 44-15 ml / min / 1.73 m2, group 3 (n=35) - patients with GFR <15 mL / min / 1.73 m2. The control group includes persons without CKD. All patients underwent general clinical examination and transthoracic echocardiography; in 86 patients the level of cystatin C in the blood serum was determined. RESULTS: Hypertrophy of the left ventricle (LVH) of the heart was detected in 87 (38.7%) of 225 patients with CKD. Hypertrophic type (type I) of myocardial DD is diagnosed in 90 (41.4%) of 225 patients with CKD. The incidence of myocardial left ventricular dysfunction of the 1st type increased with a decrease in GFR, amounting to 30, 40 and 60% in groups 1, 2 and 3, respectively. The systolic function of the left ventricular myocardium was preserved. Patients with DD were older, they had a higher body mass index (BMI), a more pronounced decrease in GFR, a higher level of fibrinogen. They were more likely to have LVH. The level of cystatin C as the kidney function worsened, but when comparing the mean levels of cystatin C in patients with the presence / absence of DD in the groups isolated depending on the stage of CKD, no statistically significant differences were found. According to the multivariate analysis, the independent predictor of DD was the age (odds ratio 1.106, 95% confidence interval 1.051-1.157, p=0.00001). CONCLUSION: DD of the myocardium of the LV is detected on average in 40% of patients with CKD, the frequency of its development increases with the progression of renal dysfunction. The development of DD is influenced by traditional factors of cardiovascular risk (age, BMI), as well as the decline in GFR and closely related structural remodeling of LV myocardium. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/30701737/Risk_factors_for_diastolic_left_ventricular_myocardial_dysfunction_in_patients_with_chronic_kidney_disease_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -