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Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein.
Pharm Biol. 2019 Dec; 57(1):38-48.PB

Abstract

CONTEXT

Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders.

OBJECTIVES

To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats.

MATERIALS AND METHODS

Wistar Male rats (180-220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks.

RESULTS

Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments.

CONCLUSIONS

C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended.

Authors+Show Affiliations

a Department of Medicine, Cardiology Section, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.a Department of Medicine, Cardiology Section, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.b Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.c An intern, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.b Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. d King Abdullah International Medical Research center (KAIMRC), Riyadh, Saudi Arabia.b Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. d King Abdullah International Medical Research center (KAIMRC), Riyadh, Saudi Arabia.e Department of Biology College of Science, College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30702358

Citation

Shatoor, Abdullah S., et al. "Crataegus Aronia Protects and Reverses Vascular Inflammation in a High Fat Diet Rat Model By an Antioxidant Mechanism and Modulating Serum Levels of Oxidized Low-density Lipoprotein." Pharmaceutical Biology, vol. 57, no. 1, 2019, pp. 38-48.
Shatoor AS, Al Humayed S, Alkhateeb MA, et al. Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein. Pharm Biol. 2019;57(1):38-48.
Shatoor, A. S., Al Humayed, S., Alkhateeb, M. A., Shatoor, K. A., Aldera, H., Alassiri, M., & Shati, A. A. (2019). Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein. Pharmaceutical Biology, 57(1), 38-48. https://doi.org/10.1080/13880209.2018.1564930
Shatoor AS, et al. Crataegus Aronia Protects and Reverses Vascular Inflammation in a High Fat Diet Rat Model By an Antioxidant Mechanism and Modulating Serum Levels of Oxidized Low-density Lipoprotein. Pharm Biol. 2019;57(1):38-48. PubMed PMID: 30702358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein. AU - Shatoor,Abdullah S, AU - Al Humayed,Suliman, AU - Alkhateeb,Mahmoud A, AU - Shatoor,Khalid A, AU - Aldera,Hussain, AU - Alassiri,Mohammed, AU - Shati,Ali A, PY - 2019/2/1/entrez PY - 2019/2/1/pubmed PY - 2019/2/8/medline KW - Hyperlipidemia KW - aorta KW - atherosclerosis KW - oxidative stress SP - 38 EP - 48 JF - Pharmaceutical biology JO - Pharm Biol VL - 57 IS - 1 N2 - CONTEXT: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovascular disorders. OBJECTIVES: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammation in rats. MATERIALS AND METHODS: Wistar Male rats (180-220 g) were divided (n = 10/group) as control fed a standard diet (STD), STD + C. aronia (200 mg/kg, orally), HFD, HFD + C. aronia and HFD post-treated with C. aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for 8 weeks, and all other treatments were administered for 4 weeks. RESULTS: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aorta tunica media (90 ± 5 vs. 160 ± 11.3 µm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 µm). It also lowered protein levels of TNF-α (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in their aorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also lowered all serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 µM) and activity of SOD (5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL). Such effects were more profound than all other treatments. CONCLUSIONS: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials is recommended. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/30702358/Crataegus_Aronia_protects_and_reverses_vascular_inflammation_in_a_high_fat_diet_rat_model_by_an_antioxidant_mechanism_and_modulating_serum_levels_of_oxidized_low_density_lipoprotein_ L2 - http://www.tandfonline.com/doi/full/10.1080/13880209.2018.1564930 DB - PRIME DP - Unbound Medicine ER -