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Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes.
J Am Coll Cardiol 2019; 73(4):400-411JACC

Abstract

BACKGROUND

The optimal coronary revascularization strategy in patients with stable ischemic heart disease (SIHD) who have type 2 diabetes (T2DM) and chronic kidney disease (CKD) remains unclear.

OBJECTIVES

This patient-level pooled analysis sought to compare outcomes of 3 large, federally-funded randomized trials in SIHD patients with T2DM and CKD (COURAGE [Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation], BARI 2D [Bypass Angioplasty Revascularization Investigation 2 Diabetes], and FREEDOM [Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-vessel Disease]).

METHODS

The primary endpoint was the composite of major adverse cardiovascular or cerebrovascular events (MACCE) including all-cause death, myocardial infarction (MI), or stroke adjusted for trial and randomization strategy.

RESULTS

Of the 4,953 patients with available estimated glomerular filtration rate (eGFR) at baseline, 1,058 had CKD (21.4%). CKD patients were more likely to be older, be female, and have a history of heart failure. CKD subjects were more likely to experience a MACCE (adjusted hazard ratio [HR]: 1.48; 95% confidence interval [CI]: 1.28 to 1.71; p = 0.0001) during a median 4.5-year follow-up. Both mild (eGFR 45 to 60 ml/min/1.73 m2) and moderate to severe (eGFR <45 ml/min/1.73 m2) CKD predicted MACCE (adjusted HRs: 1.25 and 2.26, respectively). For patients without CKD, coronary artery bypass graft (CABG) surgery combined with optimal medical therapy (OMT) was associated with lower MACCE rates compared with percutaneous coronary intervention (PCI) + OMT (adjusted HR: 0.69; 95% CI: 0.55 to 0.86; p = 0.001). For the comparison of CABG + OMT versus PCI + OMT in the CKD group, there was only a statistically significant difference in subsequent revascularization rates (HR: 0.25; 95% CI: 0.15 to 0.41; p = 0.0001) but not in MACCE rates.

CONCLUSIONS

Among SIHD patients with T2DM and no CKD, CABG + OMT significantly reduced MACCE compared with PCI + OMT. In subjects with CKD, there was a nonsignificant trend toward a better MACCE outcome with CABG and a significant reduction in subsequent revascularization.

Authors+Show Affiliations

Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address: Michael.Farkouh@uhn.ca.Albany Medical College, Albany, New York.University of Pittsburgh, Pittsburgh, Pennsylvania.University of Pittsburgh, Pittsburgh, Pennsylvania.Boston University and VA New England Health Care System, Boston, Massachusetts.Mayo Clinic, Rochester, Minnesota.Yale University and VA West Haven, West Haven, Connecticut.New England Research Institutes, Watertown, Massachusetts.University of Alabama at Birmingham, Birmingham, Alabama.St. Louis University, St. Louis, Missouri.University of British Columbia, Vancouver, British Columbia, Canada.Icahn School of Medicine at Mount Sinai, New York, New York; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30704571

Citation

Farkouh, Michael E., et al. "Impact of Chronic Kidney Disease On Outcomes of Myocardial Revascularization in Patients With Diabetes." Journal of the American College of Cardiology, vol. 73, no. 4, 2019, pp. 400-411.
Farkouh ME, Sidhu MS, Brooks MM, et al. Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes. J Am Coll Cardiol. 2019;73(4):400-411.
Farkouh, M. E., Sidhu, M. S., Brooks, M. M., Vlachos, H., Boden, W. E., Frye, R. L., ... Fuster, V. (2019). Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes. Journal of the American College of Cardiology, 73(4), pp. 400-411. doi:10.1016/j.jacc.2018.11.044.
Farkouh ME, et al. Impact of Chronic Kidney Disease On Outcomes of Myocardial Revascularization in Patients With Diabetes. J Am Coll Cardiol. 2019 02 5;73(4):400-411. PubMed PMID: 30704571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes. AU - Farkouh,Michael E, AU - Sidhu,Mandeep S, AU - Brooks,Maria M, AU - Vlachos,Helen, AU - Boden,William E, AU - Frye,Robert L, AU - Hartigan,Pamela, AU - Siami,F S, AU - Bittner,Vera A, AU - Chaitman,Bernard R, AU - Mancini,G B John, AU - Fuster,Valentin, PY - 2018/06/11/received PY - 2018/11/08/revised PY - 2018/11/12/accepted PY - 2019/2/2/entrez PY - 2019/2/2/pubmed PY - 2019/11/22/medline KW - CABG KW - CAD KW - CKD KW - PCI KW - diabetes SP - 400 EP - 411 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 73 IS - 4 N2 - BACKGROUND: The optimal coronary revascularization strategy in patients with stable ischemic heart disease (SIHD) who have type 2 diabetes (T2DM) and chronic kidney disease (CKD) remains unclear. OBJECTIVES: This patient-level pooled analysis sought to compare outcomes of 3 large, federally-funded randomized trials in SIHD patients with T2DM and CKD (COURAGE [Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation], BARI 2D [Bypass Angioplasty Revascularization Investigation 2 Diabetes], and FREEDOM [Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-vessel Disease]). METHODS: The primary endpoint was the composite of major adverse cardiovascular or cerebrovascular events (MACCE) including all-cause death, myocardial infarction (MI), or stroke adjusted for trial and randomization strategy. RESULTS: Of the 4,953 patients with available estimated glomerular filtration rate (eGFR) at baseline, 1,058 had CKD (21.4%). CKD patients were more likely to be older, be female, and have a history of heart failure. CKD subjects were more likely to experience a MACCE (adjusted hazard ratio [HR]: 1.48; 95% confidence interval [CI]: 1.28 to 1.71; p = 0.0001) during a median 4.5-year follow-up. Both mild (eGFR 45 to 60 ml/min/1.73 m2) and moderate to severe (eGFR <45 ml/min/1.73 m2) CKD predicted MACCE (adjusted HRs: 1.25 and 2.26, respectively). For patients without CKD, coronary artery bypass graft (CABG) surgery combined with optimal medical therapy (OMT) was associated with lower MACCE rates compared with percutaneous coronary intervention (PCI) + OMT (adjusted HR: 0.69; 95% CI: 0.55 to 0.86; p = 0.001). For the comparison of CABG + OMT versus PCI + OMT in the CKD group, there was only a statistically significant difference in subsequent revascularization rates (HR: 0.25; 95% CI: 0.15 to 0.41; p = 0.0001) but not in MACCE rates. CONCLUSIONS: Among SIHD patients with T2DM and no CKD, CABG + OMT significantly reduced MACCE compared with PCI + OMT. In subjects with CKD, there was a nonsignificant trend toward a better MACCE outcome with CABG and a significant reduction in subsequent revascularization. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/30704571/Impact_of_Chronic_Kidney_Disease_on_Outcomes_of_Myocardial_Revascularization_in_Patients_With_Diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(18)39525-1 DB - PRIME DP - Unbound Medicine ER -