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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.
J Nat Med. 2019 Jun; 73(3):597-601.JN

Abstract

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1-5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

Authors+Show Affiliations

Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, 770-8513, Japan.SVENSON Co., Ltd., Tokyo, 107-0052, Japan.Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. kasiwada@tokushima-u.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30706371

Citation

Sagayama, Kazumi, et al. "Lanostane-type Triterpenes From the Sclerotium of Inonotus Obliquus (Chaga Mushrooms) as Proproliferative Agents On Human Follicle Dermal Papilla Cells." Journal of Natural Medicines, vol. 73, no. 3, 2019, pp. 597-601.
Sagayama K, Tanaka N, Fukumoto T, et al. Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. J Nat Med. 2019;73(3):597-601.
Sagayama, K., Tanaka, N., Fukumoto, T., & Kashiwada, Y. (2019). Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. Journal of Natural Medicines, 73(3), 597-601. https://doi.org/10.1007/s11418-019-01280-0
Sagayama K, et al. Lanostane-type Triterpenes From the Sclerotium of Inonotus Obliquus (Chaga Mushrooms) as Proproliferative Agents On Human Follicle Dermal Papilla Cells. J Nat Med. 2019;73(3):597-601. PubMed PMID: 30706371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. AU - Sagayama,Kazumi, AU - Tanaka,Naonobu, AU - Fukumoto,Takatoshi, AU - Kashiwada,Yoshiki, Y1 - 2019/01/31/ PY - 2018/12/28/received PY - 2019/01/08/accepted PY - 2019/2/2/pubmed PY - 2019/8/14/medline PY - 2019/2/2/entrez KW - Chaga mushroom KW - Hair growth KW - Human follicle dermal papilla cell KW - Inonotus obliquus KW - Lanostane-type triterpene SP - 597 EP - 601 JF - Journal of natural medicines JO - J Nat Med VL - 73 IS - 3 N2 - Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1-5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth. SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/30706371/Lanostane_type_triterpenes_from_the_sclerotium_of_Inonotus_obliquus__Chaga_mushrooms__as_proproliferative_agents_on_human_follicle_dermal_papilla_cells_ L2 - https://dx.doi.org/10.1007/s11418-019-01280-0 DB - PRIME DP - Unbound Medicine ER -