Tags

Type your tag names separated by a space and hit enter

Protective effect of influenza vaccination on outcomes in geriatric stroke patients: A nationwide matched cohort study.
Atherosclerosis. 2019 03; 282:85-90.A

Abstract

BACKGROUND AND AIMS

The effects of influenza vaccination (IV) on stroke outcomes are unclear. The purpose of this study is to evaluate the outcomes after stroke in elderly individuals who have received an IV.

METHODS

We used Taiwan's National Health Insurance Research Database 2000-2009 claims data to conduct a nested stroke cohort study including 148,909 hospitalized stroke patients aged 66 years and older. Using a matching procedure by propensity score, we selected 25,248 stroke patients with IV and 25,248 stroke patients without IV for comparison. Logistic regression was used to calculate the odds ratios (ORs) and 95% CIs of post-stroke complications and in-hospital mortality associated with IV.

RESULTS

Stroke patients with IV had significantly lower risks of post-stroke pneumonia (OR = 0.79; 95% CI, 0.74-0.83), septicemia (OR = 0.78; 95% CI, 0.70-0.86), urinary tract infection (OR = 0.87; 95% CI, 0.83-0.92), and 30-day in-hospital mortality (OR = 0.60; 95% CI, 0.54-0.67) compared with non-IV stroke patients. Vaccinated stroke patients also had shorter hospital stays (p < 0.0001) and less medical expenditures (p < 0.0001) during stroke admission than the control group. Lower rates of post-stroke adverse events in patients with IV were noted in both sexes of all age groups with various types of stroke.

CONCLUSIONS

Stroke patients with IV showed fewer complications and lower mortality compared with non-IV patients. These findings suggest the urgent need to promote IV for this susceptible population of stroke patients.

Authors+Show Affiliations

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Anesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan.Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Anesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan.The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan.Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Anesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan.Department of Surgery, China Medical University Hospital, Taichung, Taiwan; Department of Surgery, University of Illinois, Chicago, IL, USA.Division of Infectious Diseases, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.Department of Neurology, Shuan Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Anesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan; Department of Anesthesiology, Shuan Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address: jacky48863027@yahoo.com.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30711633

Citation

Lam, Fai, et al. "Protective Effect of Influenza Vaccination On Outcomes in Geriatric Stroke Patients: a Nationwide Matched Cohort Study." Atherosclerosis, vol. 282, 2019, pp. 85-90.
Lam F, Chen TL, Shih CC, et al. Protective effect of influenza vaccination on outcomes in geriatric stroke patients: A nationwide matched cohort study. Atherosclerosis. 2019;282:85-90.
Lam, F., Chen, T. L., Shih, C. C., Lin, C. S., Yeh, C. C., Lee, Y. J., Hu, C. J., Chiou, H. Y., & Liao, C. C. (2019). Protective effect of influenza vaccination on outcomes in geriatric stroke patients: A nationwide matched cohort study. Atherosclerosis, 282, 85-90. https://doi.org/10.1016/j.atherosclerosis.2019.01.008
Lam F, et al. Protective Effect of Influenza Vaccination On Outcomes in Geriatric Stroke Patients: a Nationwide Matched Cohort Study. Atherosclerosis. 2019;282:85-90. PubMed PMID: 30711633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of influenza vaccination on outcomes in geriatric stroke patients: A nationwide matched cohort study. AU - Lam,Fai, AU - Chen,Ta-Liang, AU - Shih,Chun-Chuan, AU - Lin,Chao-Shun, AU - Yeh,Chun-Chieh, AU - Lee,Yuarn-Jang, AU - Hu,Chaur-Jong, AU - Chiou,Hung-Yi, AU - Liao,Chien-Chang, Y1 - 2019/01/26/ PY - 2018/07/16/received PY - 2018/12/14/revised PY - 2019/01/10/accepted PY - 2019/2/4/pubmed PY - 2020/5/12/medline PY - 2019/2/4/entrez KW - Infectious diseases KW - Influenza vaccination KW - Mortality KW - Stroke SP - 85 EP - 90 JF - Atherosclerosis JO - Atherosclerosis VL - 282 N2 - BACKGROUND AND AIMS: The effects of influenza vaccination (IV) on stroke outcomes are unclear. The purpose of this study is to evaluate the outcomes after stroke in elderly individuals who have received an IV. METHODS: We used Taiwan's National Health Insurance Research Database 2000-2009 claims data to conduct a nested stroke cohort study including 148,909 hospitalized stroke patients aged 66 years and older. Using a matching procedure by propensity score, we selected 25,248 stroke patients with IV and 25,248 stroke patients without IV for comparison. Logistic regression was used to calculate the odds ratios (ORs) and 95% CIs of post-stroke complications and in-hospital mortality associated with IV. RESULTS: Stroke patients with IV had significantly lower risks of post-stroke pneumonia (OR = 0.79; 95% CI, 0.74-0.83), septicemia (OR = 0.78; 95% CI, 0.70-0.86), urinary tract infection (OR = 0.87; 95% CI, 0.83-0.92), and 30-day in-hospital mortality (OR = 0.60; 95% CI, 0.54-0.67) compared with non-IV stroke patients. Vaccinated stroke patients also had shorter hospital stays (p < 0.0001) and less medical expenditures (p < 0.0001) during stroke admission than the control group. Lower rates of post-stroke adverse events in patients with IV were noted in both sexes of all age groups with various types of stroke. CONCLUSIONS: Stroke patients with IV showed fewer complications and lower mortality compared with non-IV patients. These findings suggest the urgent need to promote IV for this susceptible population of stroke patients. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/30711633/Protective_effect_of_influenza_vaccination_on_outcomes_in_geriatric_stroke_patients:_A_nationwide_matched_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(19)30021-8 DB - PRIME DP - Unbound Medicine ER -