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Prevalence and determinants of subjective cognitive decline in a representative Greek elderly population.
Int J Geriatr Psychiatry. 2019 06; 34(6):846-854.IJ

Abstract

OBJECTIVES

We studied the prevalence of subjective cognitive decline (SCD) and its determinants in a sample of 1456 cognitively normal Greek adults ≥65 years old.

METHODS/DESIGN

Subjects were evaluated by a multidisciplinary team on their neurological, medical, neuropsychological, and lifestyle profile to reach consensus diagnoses. We investigated various types of SCD, including single-question, general memory decline, specific subjective memory decline based on a list of questions and three types of subjective naming, orientation, and calculation decline.

RESULTS

In a single general question about memory decline, 28.0% responded positively. The percentage of our sample that reported at least one complaint related to subjective memory decline was 76.6%. Naming difficulties were also fairly common (26.0%), while specific deficits in orientation (5.4%) and calculations/currency handling (2.6%) were rare. The majority (84.2%) of the population reported subjective deficits in at least one cognitive domain. Genetic predisposition to dementia increased the odds for general memory decline by more than 1.7 times. For each one-unit reduction in the neuropsychological composite score (a mean of memory, executive, language, visuospatial, and attention-speed composite scores), the odds for decline in orientation increased by 40.3%. Depression/anxiety and increased cerebrovascular risk were risk factors for almost all SCD types.

CONCLUSIONS

SCD regarding memory is more frequent than non-memory decline in the cognitively normal Greek elderly population. Genetic predisposition to dementia, lower cognitive performance, affective symptoms, and increased cerebrovascular risk are associated with prevalent SCD. Further prospective research is needed to improve understanding of the evolution of SCD over time.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Vlachos GS
Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian University of Athens, First Department of Neurology, Aeginition University Hospital, Athens, Greece.
Cosentino S
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.
Kosmidis MH
Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Anastasiou CA
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Yannakoulia M
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Dardiotis E
School of Medicine, University of Thessaly, Larissa, Greece.
Hadjigeorgiou G
School of Medicine, University of Thessaly, Larissa, Greece. Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Sakka P
Athens Association of Alzheimer's Disease and Related Disorders, Maroussi, Greece.
Ntanasi E
Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian University of Athens, First Department of Neurology, Aeginition University Hospital, Athens, Greece. Athens Association of Alzheimer's Disease and Related Disorders, Maroussi, Greece.
Scarmeas N
Department of Social Medicine, Psychiatry and Neurology, National and Kapodistrian University of Athens, First Department of Neurology, Aeginition University Hospital, Athens, Greece. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.

MeSH

AgedAged, 80 and overCognitive DysfunctionFemaleGreeceHumansLife StyleMaleMemory DisordersNeuropsychological TestsPrevalenceRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30714214

Citation

Vlachos, George S., et al. "Prevalence and Determinants of Subjective Cognitive Decline in a Representative Greek Elderly Population." International Journal of Geriatric Psychiatry, vol. 34, no. 6, 2019, pp. 846-854.
Vlachos GS, Cosentino S, Kosmidis MH, et al. Prevalence and determinants of subjective cognitive decline in a representative Greek elderly population. Int J Geriatr Psychiatry. 2019;34(6):846-854.
Vlachos, G. S., Cosentino, S., Kosmidis, M. H., Anastasiou, C. A., Yannakoulia, M., Dardiotis, E., Hadjigeorgiou, G., Sakka, P., Ntanasi, E., & Scarmeas, N. (2019). Prevalence and determinants of subjective cognitive decline in a representative Greek elderly population. International Journal of Geriatric Psychiatry, 34(6), 846-854. https://doi.org/10.1002/gps.5073
Vlachos GS, et al. Prevalence and Determinants of Subjective Cognitive Decline in a Representative Greek Elderly Population. Int J Geriatr Psychiatry. 2019;34(6):846-854. PubMed PMID: 30714214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and determinants of subjective cognitive decline in a representative Greek elderly population. AU - Vlachos,George S, AU - Cosentino,Stephanie, AU - Kosmidis,Mary H, AU - Anastasiou,Costas A, AU - Yannakoulia,Mary, AU - Dardiotis,Efthimios, AU - Hadjigeorgiou,Georgios, AU - Sakka,Paraskevi, AU - Ntanasi,Eva, AU - Scarmeas,Nikolaos, Y1 - 2019/03/22/ PY - 2018/06/18/received PY - 2019/01/25/accepted PY - 2019/2/5/pubmed PY - 2020/1/14/medline PY - 2019/2/5/entrez KW - Alzheimer's disease KW - dementia KW - memory complaints KW - subjective cognitive complaints KW - subjective cognitive decline SP - 846 EP - 854 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 34 IS - 6 N2 - OBJECTIVES: We studied the prevalence of subjective cognitive decline (SCD) and its determinants in a sample of 1456 cognitively normal Greek adults ≥65 years old. METHODS/DESIGN: Subjects were evaluated by a multidisciplinary team on their neurological, medical, neuropsychological, and lifestyle profile to reach consensus diagnoses. We investigated various types of SCD, including single-question, general memory decline, specific subjective memory decline based on a list of questions and three types of subjective naming, orientation, and calculation decline. RESULTS: In a single general question about memory decline, 28.0% responded positively. The percentage of our sample that reported at least one complaint related to subjective memory decline was 76.6%. Naming difficulties were also fairly common (26.0%), while specific deficits in orientation (5.4%) and calculations/currency handling (2.6%) were rare. The majority (84.2%) of the population reported subjective deficits in at least one cognitive domain. Genetic predisposition to dementia increased the odds for general memory decline by more than 1.7 times. For each one-unit reduction in the neuropsychological composite score (a mean of memory, executive, language, visuospatial, and attention-speed composite scores), the odds for decline in orientation increased by 40.3%. Depression/anxiety and increased cerebrovascular risk were risk factors for almost all SCD types. CONCLUSIONS: SCD regarding memory is more frequent than non-memory decline in the cognitively normal Greek elderly population. Genetic predisposition to dementia, lower cognitive performance, affective symptoms, and increased cerebrovascular risk are associated with prevalent SCD. Further prospective research is needed to improve understanding of the evolution of SCD over time. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/30714214/Prevalence_and_determinants_of_subjective_cognitive_decline_in_a_representative_Greek_elderly_population_ DB - PRIME DP - Unbound Medicine ER -