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Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot.
Int J Cardiovasc Imaging. 2019 Jun; 35(6):1119-1132.IJ

Abstract

The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1-75 years) and 12 TOF patients (age = 5-23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test-retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test-retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19-61%, p < 0.001-0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20-50%, p < 0.001-0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion.

Authors+Show Affiliations

Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. alexander.ruh@northwestern.edu.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. Division of Pediatric Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30715669

Citation

Ruh, Alexander, et al. "Impact of Age and Cardiac Disease On Regional Left and Right Ventricular Myocardial Motion in Healthy Controls and Patients With Repaired Tetralogy of Fallot." The International Journal of Cardiovascular Imaging, vol. 35, no. 6, 2019, pp. 1119-1132.
Ruh A, Sarnari R, Berhane H, et al. Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot. Int J Cardiovasc Imaging. 2019;35(6):1119-1132.
Ruh, A., Sarnari, R., Berhane, H., Sidoryk, K., Lin, K., Dolan, R., Li, A., Rose, M. J., Robinson, J. D., Carr, J. C., Rigsby, C. K., & Markl, M. (2019). Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot. The International Journal of Cardiovascular Imaging, 35(6), 1119-1132. https://doi.org/10.1007/s10554-019-01544-6
Ruh A, et al. Impact of Age and Cardiac Disease On Regional Left and Right Ventricular Myocardial Motion in Healthy Controls and Patients With Repaired Tetralogy of Fallot. Int J Cardiovasc Imaging. 2019;35(6):1119-1132. PubMed PMID: 30715669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot. AU - Ruh,Alexander, AU - Sarnari,Roberto, AU - Berhane,Haben, AU - Sidoryk,Kenny, AU - Lin,Kai, AU - Dolan,Ryan, AU - Li,Arleen, AU - Rose,Michael J, AU - Robinson,Joshua D, AU - Carr,James C, AU - Rigsby,Cynthia K, AU - Markl,Michael, Y1 - 2019/02/04/ PY - 2018/12/07/received PY - 2019/01/21/accepted PY - 2019/2/5/pubmed PY - 2019/6/14/medline PY - 2019/2/5/entrez KW - Biventricular myocardial velocities KW - Cardiovascular magnetic resonance KW - Children KW - Inter-ventricular dyssynchrony KW - Repaired tetralogy of Fallot KW - Tissue phase mapping SP - 1119 EP - 1132 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 35 IS - 6 N2 - The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1-75 years) and 12 TOF patients (age = 5-23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test-retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test-retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19-61%, p < 0.001-0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20-50%, p < 0.001-0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/30715669/Impact_of_age_and_cardiac_disease_on_regional_left_and_right_ventricular_myocardial_motion_in_healthy_controls_and_patients_with_repaired_tetralogy_of_fallot_ L2 - https://doi.org/10.1007/s10554-019-01544-6 DB - PRIME DP - Unbound Medicine ER -