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Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation.
Biochimie. 2019 Apr; 159:59-65.B

Abstract

Neuroinflammation is a physiologic response aimed at protecting the central nervous system during injury. However, unresolved and chronic neuroinflammation can lead to long term damage and eventually neurologic disease including Parkinson's disease, Alzheimer's disease and dementia. Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults. Evidence suggests this protective effect is mediated, at least in part, through polarization of microglia to an anti-inflammatory phenotype that blocks the inflammatory actions of prostaglandins and promotes wound repair. This mini-review overviews the epidemiologic basis for using sEH inhibition towards neuroinflammatory disease and pharmacologic studies testing sEH inhibition in several neurologic diseases. Additionally, the combination of sEH inhibition with other eicosanoid signaling pathways is considered as an enhanced approach for developing potent neuroprotectants.

Authors+Show Affiliations

Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA. Electronic address: chmorisseau@ucdavis.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30716359

Citation

Kodani, Sean D., and Christophe Morisseau. "Role of Epoxy-fatty Acids and Epoxide Hydrolases in the Pathology of Neuro-inflammation." Biochimie, vol. 159, 2019, pp. 59-65.
Kodani SD, Morisseau C. Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. Biochimie. 2019;159:59-65.
Kodani, S. D., & Morisseau, C. (2019). Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. Biochimie, 159, 59-65. https://doi.org/10.1016/j.biochi.2019.01.020
Kodani SD, Morisseau C. Role of Epoxy-fatty Acids and Epoxide Hydrolases in the Pathology of Neuro-inflammation. Biochimie. 2019;159:59-65. PubMed PMID: 30716359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. AU - Kodani,Sean D, AU - Morisseau,Christophe, Y1 - 2019/02/01/ PY - 2018/12/04/received PY - 2019/01/29/accepted PY - 2020/04/01/pmc-release PY - 2019/2/5/pubmed PY - 2019/4/4/medline PY - 2019/2/5/entrez KW - Alzheimer disease KW - Dementia KW - Epoxide hydrolase KW - Epoxyeicosatrienoic acids KW - Parkinson's disease SP - 59 EP - 65 JF - Biochimie JO - Biochimie VL - 159 N2 - Neuroinflammation is a physiologic response aimed at protecting the central nervous system during injury. However, unresolved and chronic neuroinflammation can lead to long term damage and eventually neurologic disease including Parkinson's disease, Alzheimer's disease and dementia. Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults. Evidence suggests this protective effect is mediated, at least in part, through polarization of microglia to an anti-inflammatory phenotype that blocks the inflammatory actions of prostaglandins and promotes wound repair. This mini-review overviews the epidemiologic basis for using sEH inhibition towards neuroinflammatory disease and pharmacologic studies testing sEH inhibition in several neurologic diseases. Additionally, the combination of sEH inhibition with other eicosanoid signaling pathways is considered as an enhanced approach for developing potent neuroprotectants. SN - 1638-6183 UR - https://www.unboundmedicine.com/medline/citation/30716359/Role_of_epoxy_fatty_acids_and_epoxide_hydrolases_in_the_pathology_of_neuro_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9084(19)30028-8 DB - PRIME DP - Unbound Medicine ER -