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Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review.
Int J Mol Sci. 2019 Feb 01; 20(3)IJ

Abstract

Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed.

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Authors+Show Affiliations

Roumeliotis S
Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece. st_roumeliotis@hotmail.com.
Dounousi E
Department of Nephrology, Medical School, University of Ioannina, 45110 Ioannina, Greece. evangeldou@gmail.com.
Eleftheriadis T
Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece. teleftheriadis@yahoo.com.
Liakopoulos V
Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece. liakopul@otenet.gr.

MeSH

Biological TransportCalcium-Binding ProteinsCardiovascular DiseasesDietary SupplementsExtracellular Matrix ProteinsGene Expression RegulationHumansPhosphorylationProtein Processing, Post-TranslationalRenal Insufficiency, ChronicSurvival AnalysisVascular CalcificationVascular StiffnessVitamin KVitamin K Deficiency

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30717170

Clinical Trial Links

The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis

Citation

Roumeliotis, Stefanos, et al. "Association of the Inactive Circulating Matrix Gla Protein With Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: a Review." International Journal of Molecular Sciences, vol. 20, no. 3, 2019.
Roumeliotis S, Dounousi E, Eleftheriadis T, et al. Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review. Int J Mol Sci. 2019;20(3).
Roumeliotis, S., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V. (2019). Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/ijms20030628
Roumeliotis S, et al. Association of the Inactive Circulating Matrix Gla Protein With Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: a Review. Int J Mol Sci. 2019 Feb 1;20(3) PubMed PMID: 30717170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review. AU - Roumeliotis,Stefanos, AU - Dounousi,Evangelia, AU - Eleftheriadis,Theodoros, AU - Liakopoulos,Vassilios, Y1 - 2019/02/01/ PY - 2019/01/05/received PY - 2019/01/29/revised PY - 2019/01/30/accepted PY - 2019/2/6/entrez PY - 2019/2/6/pubmed PY - 2019/5/18/medline KW - calcification KW - cardiovascular disease KW - dpucMGP KW - matrix Gla protein KW - mortality KW - renal function KW - vitamin K. JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 3 N2 - Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Vitamin K deficiency leads to the inactive uncarboxylated, dephosphorylated form of MGP (dpucMGP). We aimed to review the existing data on the association between circulating dpucMGP and vascular calcification, renal function, mortality, and cardiovascular disease in distinct populations. Moreover, the association between vitamin K supplementation and serum levels of dpucMGP was also reviewed. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/30717170/Association_of_the_Inactive_Circulating_Matrix_Gla_Protein_with_Vitamin_K_Intake_Calcification_Mortality_and_Cardiovascular_Disease:_A_Review_ DB - PRIME DP - Unbound Medicine ER -