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Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China.
Dis Markers. 2019; 2019:3736198.DM

Abstract

Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expressed genes in KBD. Correlation analysis and multiple logistic regression analysis were performed using gene expression and clinical parameters. Immunohistochemistry (IHC) was used to detect the expression of related proteins in articular cartilage tissues. Thirty-nine differentially expressed genes were identified in patients with KBD. Nine differentially expressed genes were correlated with the metacarpal length/metacarpal breadth index. FZD1 was identified as having statistical significance in establishing the regression model of clinical parameters and gene expression. FZD1 expression levels were remarkably reduced in patients with KBD. Our results indicate that FZD1 could be involved in the pathological process of phalanges tuberositas and brachydactylia and may provide new insight into the pathogenesis of articular cartilage destruction observed in patients with KBD.

Authors+Show Affiliations

School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China. Xi'an Jiaotong University Global Health Institute, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China. School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China. Shaanxi Provincial Institute for Endemic Disease Control, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China. Shaanxi Provincial Institute for Endemic Disease Control, Xi'an 710061, China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30719180

Citation

Wang, Xi, et al. "Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients With Kashin-Beck Disease, an Endemic Osteoarthritis in China." Disease Markers, vol. 2019, 2019, p. 3736198.
Wang X, Ning Y, Zhang P, et al. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Dis Markers. 2019;2019:3736198.
Wang, X., Ning, Y., Zhang, P., Yang, L., Li, C., Zhou, R., & Guo, X. (2019). Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. Disease Markers, 2019, 3736198. https://doi.org/10.1155/2019/3736198
Wang X, et al. Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients With Kashin-Beck Disease, an Endemic Osteoarthritis in China. Dis Markers. 2019;2019:3736198. PubMed PMID: 30719180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China. AU - Wang,Xi, AU - Ning,Yujie, AU - Zhang,Pan, AU - Yang,Lei, AU - Li,Cheng, AU - Zhou,Rong, AU - Guo,Xiong, Y1 - 2019/01/03/ PY - 2018/08/08/received PY - 2018/10/17/revised PY - 2018/10/24/accepted PY - 2019/2/6/entrez PY - 2019/2/6/pubmed PY - 2019/5/30/medline SP - 3736198 EP - 3736198 JF - Disease markers JO - Dis. Markers VL - 2019 N2 - Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expressed genes in KBD. Correlation analysis and multiple logistic regression analysis were performed using gene expression and clinical parameters. Immunohistochemistry (IHC) was used to detect the expression of related proteins in articular cartilage tissues. Thirty-nine differentially expressed genes were identified in patients with KBD. Nine differentially expressed genes were correlated with the metacarpal length/metacarpal breadth index. FZD1 was identified as having statistical significance in establishing the regression model of clinical parameters and gene expression. FZD1 expression levels were remarkably reduced in patients with KBD. Our results indicate that FZD1 could be involved in the pathological process of phalanges tuberositas and brachydactylia and may provide new insight into the pathogenesis of articular cartilage destruction observed in patients with KBD. SN - 1875-8630 UR - https://www.unboundmedicine.com/medline/citation/30719180/Biological_Analysis_of_Gene_Expression_and_Clinical_Variables_Suggest_FZD1_as_a_Novel_Biomarker_for_Patients_with_Kashin_Beck_Disease_an_Endemic_Osteoarthritis_in_China_ L2 - https://dx.doi.org/10.1155/2019/3736198 DB - PRIME DP - Unbound Medicine ER -