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Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin.
J Ethnopharmacol. 2019 May 10; 235:1-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L.) has important pharmacological functions, including anti-inflammatory, antioxidant, and hypoglycemic activities. Olive leaves are used in traditional medicine for diabetes and hypertension.

AIM OF THE STUDY

To evaluate the effect of the ethanolic extract of olive leaves (EEOL) on the metabolism of rats with diabetes induced by a high-fat diet and low dose of streptozotocin (STZ).

MATERIALS AND METHODS

Male Wistar rats were either given normal feed or a high-fat diet (70% standard laboratory feed, 15% sucrose, 10% lard and 5% yolk powder) for four weeks, followed by administration of STZ (35 mg/kg, via ip). Animals with fasting glucose levels above 200 mg/dL were considered diabetic. Animals were divided into 5 groups, which received ethanol (10 mL/kg), metformin (250 mg/kg), or EEOL at doses of 200 and 400 mg/kg during 10 weeks by oral gavage. Blood samples were used to measure hematological and biochemical parameters, and kidneys were removed for posterior analysis. Body weight was recorded weekly.

RESULTS

A significant decrease in body weight was observed among diabetic animals treated with ethanol and EEOL compared to the control group. Moreover, animals treated with EEOL showed an improvement in glucose levels and in levels of inflammatory and metabolic markers when compared to diabetic animals.

CONCLUSIONS

The results indicate a potential anti-diabetic activity of olive leaves, however more studies are needed to validate clinical effects.

Authors+Show Affiliations

Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: camilleguex@yahoo.com.br.Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: fernanda_zr@yahoo.com.br.Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: patriciardejesus@gmail.com.Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: juliana.brondani@gmail.com.Departamento de Tecnologia e Ciência dos Alimentos , Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: gilberti@gilbertinutri.com.br.Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address: lgfbauermann@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30721736

Citation

Guex, Camille Gaube, et al. "Antidiabetic Effects of Olea Europaea L. Leaves in Diabetic Rats Induced By High-fat Diet and Low-dose Streptozotocin." Journal of Ethnopharmacology, vol. 235, 2019, pp. 1-7.
Guex CG, Reginato FZ, de Jesus PR, et al. Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin. J Ethnopharmacol. 2019;235:1-7.
Guex, C. G., Reginato, F. Z., de Jesus, P. R., Brondani, J. C., Lopes, G. H. H., & Bauermann, L. F. (2019). Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin. Journal of Ethnopharmacology, 235, 1-7. https://doi.org/10.1016/j.jep.2019.02.001
Guex CG, et al. Antidiabetic Effects of Olea Europaea L. Leaves in Diabetic Rats Induced By High-fat Diet and Low-dose Streptozotocin. J Ethnopharmacol. 2019 May 10;235:1-7. PubMed PMID: 30721736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin. AU - Guex,Camille Gaube, AU - Reginato,Fernanda Ziegler, AU - de Jesus,Patrícia Romualdo, AU - Brondani,Juliana Calil, AU - Lopes,Gilberti Helena Hübscher, AU - Bauermann,Liliane de Freitas, Y1 - 2019/02/02/ PY - 2018/05/24/received PY - 2019/01/22/revised PY - 2019/02/01/accepted PY - 2019/2/6/pubmed PY - 2019/4/16/medline PY - 2019/2/6/entrez KW - 6-hydroxycoumarin (PubChem CID: 99477) KW - Apigenin (PubChem CID: 5280443) KW - Caffeic acid (PubChem CID: 689043) KW - Diabetes mellitus KW - Ferulic acid (PubChem CID: 445858) KW - High-fat diet KW - Luteolin (PubChem CID: 5280445) KW - Oleaceae KW - Olive KW - Quercetin (PubChem CID: 5280343) KW - Quercitrin (PubChem CID: 5280459) KW - Resveratrol (PubChem CID: 445154) KW - Rutin (PubChem CID: 5280805) KW - Streptozotocin KW - Vanilinic acid (PubChem CID: 8468) KW - p-coumaric acid (PubChem CID: 637542) SP - 1 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 235 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L.) has important pharmacological functions, including anti-inflammatory, antioxidant, and hypoglycemic activities. Olive leaves are used in traditional medicine for diabetes and hypertension. AIM OF THE STUDY: To evaluate the effect of the ethanolic extract of olive leaves (EEOL) on the metabolism of rats with diabetes induced by a high-fat diet and low dose of streptozotocin (STZ). MATERIALS AND METHODS: Male Wistar rats were either given normal feed or a high-fat diet (70% standard laboratory feed, 15% sucrose, 10% lard and 5% yolk powder) for four weeks, followed by administration of STZ (35 mg/kg, via ip). Animals with fasting glucose levels above 200 mg/dL were considered diabetic. Animals were divided into 5 groups, which received ethanol (10 mL/kg), metformin (250 mg/kg), or EEOL at doses of 200 and 400 mg/kg during 10 weeks by oral gavage. Blood samples were used to measure hematological and biochemical parameters, and kidneys were removed for posterior analysis. Body weight was recorded weekly. RESULTS: A significant decrease in body weight was observed among diabetic animals treated with ethanol and EEOL compared to the control group. Moreover, animals treated with EEOL showed an improvement in glucose levels and in levels of inflammatory and metabolic markers when compared to diabetic animals. CONCLUSIONS: The results indicate a potential anti-diabetic activity of olive leaves, however more studies are needed to validate clinical effects. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/30721736/Antidiabetic_effects_of_Olea_europaea_L__leaves_in_diabetic_rats_induced_by_high_fat_diet_and_low_dose_streptozotocin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(18)31896-8 DB - PRIME DP - Unbound Medicine ER -