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Cardioactive Steroid Toxicity

Abstract

Cardioactive steroids (CAS) are medically important compounds historically used for conditions like edema and "dropsy." There is literature from the 17th century regarding their therapeutic effects. They are available in several plants including oleander, foxglove, lily of the valley, red squill, dogbane, common milkweed plant, etc. Leaves of Digitalis lanata contain digoxin while seeds of Digitalis purpurea may contain digitalin. Several Chinese herbal medications and aphrodisiacs may also contain cardioactive steroids. Historians believe the selection of yellow contrast in Van Gogh's painting was likely secondary to digitalis toxicity. Digoxin is the most well known cardioactive steroid with application in the treatment of congestive heart failure and for the control of ventricular rate in atrial tachyarrhythmias. It is available in tablet form and liquid filled capsules that can increase its bioavailability. Other less commonly used cardioactive steroids include lanatoside C, digitoxin, ouabain, gitalin, and deslanoside.

Links

  • NCBI Bookshelf
  • Publisher

    StatPearls Publishing
    Treasure Island (FL)

    Language

    eng

    PubMed ID

    30725648

    Citation

    Ershad M, Khalid MM: Cardioactive Steroid Toxicity.StatPearls. StatPearls Publishing, 2019, Treasure Island (FL).
    Ershad M, Khalid MM. Cardioactive Steroid Toxicity. StatPearls. Treasure Island (FL): StatPearls Publishing; 2019.
    Ershad M & Khalid MM. (2019). Cardioactive Steroid Toxicity. In StatPearls. Treasure Island (FL): StatPearls Publishing;
    Ershad M, Khalid MM. StatPearls. Treasure Island (FL): StatPearls Publishing; 2019.
    * Article titles in AMA citation format should be in sentence-case
    TY - CHAP T1 - Cardioactive Steroid Toxicity BT - StatPearls A1 - Ershad,Muhammed, AU - Khalid,Muhammad M., Y1 - 2019/01// PY - 2019/2/7/pubmed PY - 2019/2/7/medline PY - 2019/2/7/entrez N2 - Cardioactive steroids (CAS) are medically important compounds historically used for conditions like edema and "dropsy." There is literature from the 17th century regarding their therapeutic effects. They are available in several plants including oleander, foxglove, lily of the valley, red squill, dogbane, common milkweed plant, etc. Leaves of Digitalis lanata contain digoxin while seeds of Digitalis purpurea may contain digitalin. Several Chinese herbal medications and aphrodisiacs may also contain cardioactive steroids. Historians believe the selection of yellow contrast in Van Gogh's painting was likely secondary to digitalis toxicity. Digoxin is the most well known cardioactive steroid with application in the treatment of congestive heart failure and for the control of ventricular rate in atrial tachyarrhythmias. It is available in tablet form and liquid filled capsules that can increase its bioavailability. Other less commonly used cardioactive steroids include lanatoside C, digitoxin, ouabain, gitalin, and deslanoside. PB - StatPearls Publishing CY - Treasure Island (FL) UR - https://www.unboundmedicine.com/medline/citation/30725648/StatPearls:_Cardioactive_Steroid_Toxicity L2 - https://www.ncbi.nlm.nih.gov/books/NBK536963 DB - PRIME DP - Unbound Medicine ER -
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