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The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus.
Curr Diabetes Rev. 2019; 15(6):480-485.CD

Abstract

BACKGROUND

Symbiotic interactions of microorganisms are widespread in nature, and support fundamentally important processes linking health and disease to the bacterial ecology. Intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. It participates in the development of the postnatal immune system as well as oral tolerance and immunity. The recently explored impact of the microbiota on energy metabolism, gut hormone regulation and the gut-brain axis was judged to be a fascinating topic and of great value in the future, and can have a clinical role in the management of obesity and diabetes.

OBJECTIVE

To assess the impact of the gut microbe, Lactobacillus acidophilus, in patients with type 2 Diabetes Mellitus (controlled and uncontrolled) compared to healthy individuals, as a preliminary approach to future treatment with probiotics, prebiotics or diet modulation.

METHODS

A case control study was conducted on 30 diabetic patients and 10 control individuals. All patients were subjected to full history, thorough clinical examination, and laboratory measurement of fasting blood sugar, 2 hours post prandial, Glycosylated Hemoglobin (HbA1C), CRP (C-Reactive Protein), Lipid profile, and Identification of stool Lactobacillus acidophilus by PCR (polymerase chain reaction) technique.

RESULTS

Significantly lower Stool Lactobacillus acidophilus PCR count among diabetic patients when compared to healthy control individuals.

CONCLUSION

Stool Lactobacillus acidophilus PCR count was lower among type 2 diabetic patients, which may show relationship of lactobacillus with type 2 diabetes mellitus. However, further studies are needed to determine correlation or causation of this relationship.

Authors+Show Affiliations

Department of Internal Medicine, Endocrinology and Metabolism, Ain Shams University Hospital, Cairo 11566, Egypt.Complementary and Alternative Medicine Department, National Research Center, Cairo 11566, Egypt.Internal Medicine, Endocrinology and Metabolism, Ain Shams University Hospital, Cairo 11566, Egypt.Internal Medicine, National Research Center, Cairo 11566, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30727901

Citation

Halawa, Mohamed R., et al. "The Gut Microbiome, Lactobacillus Acidophilus; Relation With Type 2 Diabetes Mellitus." Current Diabetes Reviews, vol. 15, no. 6, 2019, pp. 480-485.
Halawa MR, El-Salam MA, Mostafa BM, et al. The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus. Curr Diabetes Rev. 2019;15(6):480-485.
Halawa, M. R., El-Salam, M. A., Mostafa, B. M., & Sallout, S. S. (2019). The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus. Current Diabetes Reviews, 15(6), 480-485. https://doi.org/10.2174/1573399815666190206162143
Halawa MR, et al. The Gut Microbiome, Lactobacillus Acidophilus; Relation With Type 2 Diabetes Mellitus. Curr Diabetes Rev. 2019;15(6):480-485. PubMed PMID: 30727901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus. AU - Halawa,Mohamed R, AU - El-Salam,Mouchira Abd, AU - Mostafa,Bassem M, AU - Sallout,Salma S, PY - 2018/05/28/received PY - 2018/11/22/revised PY - 2019/01/28/accepted PY - 2019/2/8/pubmed PY - 2020/2/15/medline PY - 2019/2/8/entrez KW - Gut microbiome KW - Lactobacillus acidophilus KW - diabetes mellitus KW - polymerase chain reaction KW - prebiotic KW - probiotic. SP - 480 EP - 485 JF - Current diabetes reviews JO - Curr Diabetes Rev VL - 15 IS - 6 N2 - BACKGROUND: Symbiotic interactions of microorganisms are widespread in nature, and support fundamentally important processes linking health and disease to the bacterial ecology. Intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. It participates in the development of the postnatal immune system as well as oral tolerance and immunity. The recently explored impact of the microbiota on energy metabolism, gut hormone regulation and the gut-brain axis was judged to be a fascinating topic and of great value in the future, and can have a clinical role in the management of obesity and diabetes. OBJECTIVE: To assess the impact of the gut microbe, Lactobacillus acidophilus, in patients with type 2 Diabetes Mellitus (controlled and uncontrolled) compared to healthy individuals, as a preliminary approach to future treatment with probiotics, prebiotics or diet modulation. METHODS: A case control study was conducted on 30 diabetic patients and 10 control individuals. All patients were subjected to full history, thorough clinical examination, and laboratory measurement of fasting blood sugar, 2 hours post prandial, Glycosylated Hemoglobin (HbA1C), CRP (C-Reactive Protein), Lipid profile, and Identification of stool Lactobacillus acidophilus by PCR (polymerase chain reaction) technique. RESULTS: Significantly lower Stool Lactobacillus acidophilus PCR count among diabetic patients when compared to healthy control individuals. CONCLUSION: Stool Lactobacillus acidophilus PCR count was lower among type 2 diabetic patients, which may show relationship of lactobacillus with type 2 diabetes mellitus. However, further studies are needed to determine correlation or causation of this relationship. SN - 1875-6417 UR - https://www.unboundmedicine.com/medline/citation/30727901/The_Gut_Microbiome_Lactobacillus_acidophilus L2 - http://www.eurekaselect.com/169693/article DB - PRIME DP - Unbound Medicine ER -