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Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Reprod Biol Endocrinol. 2019 Feb 06; 17(1):17.RB

Abstract

The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). The PUBMED, Web of Science, and EMBASE databases were searched systematically for eligible randomized controlled trials (RCTs) from English language articles published from database inception to September 2018. Data were independently extracted and analyzed using the fixed-effects model or random-effects model according to the heterogeneity of the data. Four RCTs including 621 patients (309 in the LE group and 312 in the LOD group) met the inclusion criteria. There were no differences with regard to ovulation rate (relative risk [RR] 1.12; 95% confidence interval [CI] 0.93 to 1.34; P = 0.12, I2 = 90%, 541 patients, three studies), pregnancy rate (RR 1.21; 95% CI 0.95 to 1.53; P = 0.12, I2 = 0%, 621 patients, four studies), live birth rate (RR 1.27; 95% CI 0.96 to 1.68; P = 0.09, I2 = 19%, 541 patients, three studies), and abortion rate (RR 0.7; 95% CI 0.3 to 1.61; P = 0.40, I2 = 0%, 621 patients, four studies) between the two groups. These results indicated that LE and LOD appear to be equally effective in achieving live birth rate in patients with CC-resistant PCOS.

Authors+Show Affiliations

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China. tjxiawei@126.com. Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. tjxiawei@126.com.Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China. reprodcentre@163.com. Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. reprodcentre@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30728032

Citation

Yu, Qiong, et al. "Letrozole Versus Laparoscopic Ovarian Drilling in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Reproductive Biology and Endocrinology : RB&E, vol. 17, no. 1, 2019, p. 17.
Yu Q, Hu S, Wang Y, et al. Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2019;17(1):17.
Yu, Q., Hu, S., Wang, Y., Cheng, G., Xia, W., & Zhu, C. (2019). Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reproductive Biology and Endocrinology : RB&E, 17(1), 17. https://doi.org/10.1186/s12958-019-0461-3
Yu Q, et al. Letrozole Versus Laparoscopic Ovarian Drilling in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Reprod Biol Endocrinol. 2019 Feb 6;17(1):17. PubMed PMID: 30728032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. AU - Yu,Qiong, AU - Hu,Shifu, AU - Wang,Yingying, AU - Cheng,Guiping, AU - Xia,Wei, AU - Zhu,Changhong, Y1 - 2019/02/06/ PY - 2018/04/26/received PY - 2019/01/28/accepted PY - 2019/2/8/entrez PY - 2019/2/8/pubmed PY - 2019/2/26/medline KW - Laparoscopic ovarian drilling KW - Letrozole KW - Ovulation induction KW - Polycystic ovary syndrome SP - 17 EP - 17 JF - Reproductive biology and endocrinology : RB&E JO - Reprod. Biol. Endocrinol. VL - 17 IS - 1 N2 - The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). The PUBMED, Web of Science, and EMBASE databases were searched systematically for eligible randomized controlled trials (RCTs) from English language articles published from database inception to September 2018. Data were independently extracted and analyzed using the fixed-effects model or random-effects model according to the heterogeneity of the data. Four RCTs including 621 patients (309 in the LE group and 312 in the LOD group) met the inclusion criteria. There were no differences with regard to ovulation rate (relative risk [RR] 1.12; 95% confidence interval [CI] 0.93 to 1.34; P = 0.12, I2 = 90%, 541 patients, three studies), pregnancy rate (RR 1.21; 95% CI 0.95 to 1.53; P = 0.12, I2 = 0%, 621 patients, four studies), live birth rate (RR 1.27; 95% CI 0.96 to 1.68; P = 0.09, I2 = 19%, 541 patients, three studies), and abortion rate (RR 0.7; 95% CI 0.3 to 1.61; P = 0.40, I2 = 0%, 621 patients, four studies) between the two groups. These results indicated that LE and LOD appear to be equally effective in achieving live birth rate in patients with CC-resistant PCOS. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/30728032/Letrozole_versus_laparoscopic_ovarian_drilling_in_clomiphene_citrate-resistant_women_with_polycystic_ovary_syndrome:_a_systematic_review_and_meta-analysis_of_randomized_controlled_trials L2 - https://rbej.biomedcentral.com/articles/10.1186/s12958-019-0461-3 DB - PRIME DP - Unbound Medicine ER -