Tags

Type your tag names separated by a space and hit enter

Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion.
Dis Colon Rectum 2019; 62(4):422-428DC

Abstract

BACKGROUND

Correctly predicting the depth of tumor invasion in the colorectal wall is crucial for successful endoscopic resection of superficial colorectal neoplasms.

OBJECTIVE

The aim of this study was to assess the accuracy of magnifying chromoendoscopy in a Western medical center to predict the depth of invasion by the pit pattern classification in patients with colorectal neoplasms with a high risk of submucosal invasion.

DESIGN

This single-center retrospective study, from a prospectively collected database, was conducted between April 2009 and June 2015.

SETTINGS

The study was conducted at a single academic center.

PATIENTS

Consecutive patients with colorectal neoplasms with high risk of submucosal invasion were included. These tumors were defined by large (≥20 mm) sessile polyps (nonpedunculated), laterally spreading tumors, or depressed lesions of any size.

INTERVENTIONS

Patients underwent magnifying chromoendoscopy and were classified according to the Kudo pit pattern. The therapeutic decision, endoscopic or surgery, was defined by the magnification assessment.

MAIN OUTCOME MEASURES

Sensitivity, specificity, and positive and negative predictive values of magnifying chromoendoscopy for assessment of these lesions were determined.

RESULTS

A total of 123 lesions were included, with a mean size of 54.0 ± 37.1 mm. Preoperative magnifying chromoendoscopy with pit pattern classification had 73.3% sensitivity, 100% specificity, 100% positive predictive value, 96.4% negative predictive value, and 96.7% accuracy to predict depth of invasion and consequently to guide the appropriate treatment. Thirty-three rectal lesions were also examined by MRI, and 31 were diagnosed as T2 lesions. Twenty two (70.1%) of these lesions were diagnosed as noninvasive by magnifying colonoscopy, were treated by endoscopic resection, and met the curative criteria.

LIMITATIONS

This was a single-center retrospective study with a single expert endoscopist experience.

CONCLUSIONS

Magnifying chromoendoscopy is highly accurate for assessing colorectal neoplasms suspicious for submucosal invasion and can help to select the most appropriate treatment. See Video Abstract at http://links.lww.com/DCR/A920.

Authors+Show Affiliations

Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Pathology, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30730457

Citation

Kawaguti, Fabio S., et al. "Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion." Diseases of the Colon and Rectum, vol. 62, no. 4, 2019, pp. 422-428.
Kawaguti FS, Franco MC, Martins BC, et al. Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion. Dis Colon Rectum. 2019;62(4):422-428.
Kawaguti, F. S., Franco, M. C., Martins, B. C., Segateli, V., Marques, C. F. S., Nahas, C. S. R., ... Maluf-Filho, F. (2019). Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion. Diseases of the Colon and Rectum, 62(4), pp. 422-428. doi:10.1097/DCR.0000000000001343.
Kawaguti FS, et al. Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion. Dis Colon Rectum. 2019;62(4):422-428. PubMed PMID: 30730457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion. AU - Kawaguti,Fabio S, AU - Franco,Matheus C, AU - Martins,Bruno C, AU - Segateli,Vanderlei, AU - Marques,Carlos F S, AU - Nahas,Caio S R, AU - Pinto,Rodrigo A, AU - Safatle-Ribeiro,Adriana V, AU - Ribeiro-Junior,Ulysses, AU - Nahas,Sergio C, AU - Maluf-Filho,Fauze, PY - 2019/2/8/pubmed PY - 2019/5/2/medline PY - 2019/2/8/entrez SP - 422 EP - 428 JF - Diseases of the colon and rectum JO - Dis. Colon Rectum VL - 62 IS - 4 N2 - BACKGROUND: Correctly predicting the depth of tumor invasion in the colorectal wall is crucial for successful endoscopic resection of superficial colorectal neoplasms. OBJECTIVE: The aim of this study was to assess the accuracy of magnifying chromoendoscopy in a Western medical center to predict the depth of invasion by the pit pattern classification in patients with colorectal neoplasms with a high risk of submucosal invasion. DESIGN: This single-center retrospective study, from a prospectively collected database, was conducted between April 2009 and June 2015. SETTINGS: The study was conducted at a single academic center. PATIENTS: Consecutive patients with colorectal neoplasms with high risk of submucosal invasion were included. These tumors were defined by large (≥20 mm) sessile polyps (nonpedunculated), laterally spreading tumors, or depressed lesions of any size. INTERVENTIONS: Patients underwent magnifying chromoendoscopy and were classified according to the Kudo pit pattern. The therapeutic decision, endoscopic or surgery, was defined by the magnification assessment. MAIN OUTCOME MEASURES: Sensitivity, specificity, and positive and negative predictive values of magnifying chromoendoscopy for assessment of these lesions were determined. RESULTS: A total of 123 lesions were included, with a mean size of 54.0 ± 37.1 mm. Preoperative magnifying chromoendoscopy with pit pattern classification had 73.3% sensitivity, 100% specificity, 100% positive predictive value, 96.4% negative predictive value, and 96.7% accuracy to predict depth of invasion and consequently to guide the appropriate treatment. Thirty-three rectal lesions were also examined by MRI, and 31 were diagnosed as T2 lesions. Twenty two (70.1%) of these lesions were diagnosed as noninvasive by magnifying colonoscopy, were treated by endoscopic resection, and met the curative criteria. LIMITATIONS: This was a single-center retrospective study with a single expert endoscopist experience. CONCLUSIONS: Magnifying chromoendoscopy is highly accurate for assessing colorectal neoplasms suspicious for submucosal invasion and can help to select the most appropriate treatment. See Video Abstract at http://links.lww.com/DCR/A920. SN - 1530-0358 UR - https://www.unboundmedicine.com/medline/citation/30730457/Role_of_Magnification_Chromoendoscopy_in_the_Management_of_Colorectal_Neoplastic_Lesions_Suspicious_for_Submucosal_Invasion_ L2 - http://Insights.ovid.com/pubmed?pmid=30730457 DB - PRIME DP - Unbound Medicine ER -