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Delayed Anaphylaxis to Mammalian Meat: A Fascinating Disease and Captivating Story.
S D Med. 2018 Oct; 71(10):463-465.SD

Abstract

Delayed anaphylaxis to mammalian meat is a newly recognized IgE-mediated syndrome associated with Lone Star tick bites. IgE-mediated anaphylaxis classically occurs within one hour of exposure to the allergen, which is typically a protein epitope. However, in this disease, circulating antibodies to a carbohydrate, alpha-gal (galactose-alpha-1,3-galactose), stimulate the anaphylactic cascade with hives, diarrhea, abdominal cramps, respiratory distress and anaphylactic shock developing after ingestion of beef, pork or lamb meat. The delayed onset of symptoms three to six hours after ingestion of meat is unique. Recognition and understanding of this disease is important for treating and educating patients with suggestive symptoms. Avoidance of red meat is the recommended therapy.

Authors+Show Affiliations

Internal Medicine Residency Program, Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.Division of General Internal Medicine, Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30731522

Citation

Abdallah, Mohamed A., and Eric A. Larson. "Delayed Anaphylaxis to Mammalian Meat: a Fascinating Disease and Captivating Story." South Dakota Medicine : the Journal of the South Dakota State Medical Association, vol. 71, no. 10, 2018, pp. 463-465.
Abdallah MA, Larson EA. Delayed Anaphylaxis to Mammalian Meat: A Fascinating Disease and Captivating Story. S D Med. 2018;71(10):463-465.
Abdallah, M. A., & Larson, E. A. (2018). Delayed Anaphylaxis to Mammalian Meat: A Fascinating Disease and Captivating Story. South Dakota Medicine : the Journal of the South Dakota State Medical Association, 71(10), 463-465.
Abdallah MA, Larson EA. Delayed Anaphylaxis to Mammalian Meat: a Fascinating Disease and Captivating Story. S D Med. 2018;71(10):463-465. PubMed PMID: 30731522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed Anaphylaxis to Mammalian Meat: A Fascinating Disease and Captivating Story. AU - Abdallah,Mohamed A, AU - Larson,Eric A, PY - 2019/2/8/entrez PY - 2019/2/8/pubmed PY - 2019/4/30/medline SP - 463 EP - 465 JF - South Dakota medicine : the journal of the South Dakota State Medical Association JO - S D Med VL - 71 IS - 10 N2 - Delayed anaphylaxis to mammalian meat is a newly recognized IgE-mediated syndrome associated with Lone Star tick bites. IgE-mediated anaphylaxis classically occurs within one hour of exposure to the allergen, which is typically a protein epitope. However, in this disease, circulating antibodies to a carbohydrate, alpha-gal (galactose-alpha-1,3-galactose), stimulate the anaphylactic cascade with hives, diarrhea, abdominal cramps, respiratory distress and anaphylactic shock developing after ingestion of beef, pork or lamb meat. The delayed onset of symptoms three to six hours after ingestion of meat is unique. Recognition and understanding of this disease is important for treating and educating patients with suggestive symptoms. Avoidance of red meat is the recommended therapy. SN - 0038-3317 UR - https://www.unboundmedicine.com/medline/citation/30731522/Delayed_Anaphylaxis_to_Mammalian_Meat:_A_Fascinating_Disease_and_Captivating_Story_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -