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Systematic Review of miRNA as Biomarkers in Alzheimer's Disease.
Mol Neurobiol. 2019 Sep; 56(9):6156-6167.MN

Abstract

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment. Small non-coding microRNA (miRNA) sequences have been found to be deregulated in the peripheral blood of Alzheimer patients. A systematic review was conducted to extract all miRNA found to be significantly deregulated in the peripheral blood. These deregulated miRNAs were cross-referenced against the miRNAs deregulated in the brain at Braak Stage III. This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. After network analysis of the 10 miRNAs, they were found to be associated with the immune system, cell cycle, gene expression, cellular response to stress, neuron growth factor signalling, wnt signalling, cellular senescence, and Rho GTPases.

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Authors+Show Affiliations

Swarbrick S
Centre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
Wragg N
Centre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
Ghosh S
Centre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
Stolzing A
Centre for Biological Engineering, Wolfscon School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK. A.Stolzing@lboro.ac.uk.

MeSH

Alzheimer DiseaseAnimalsBiomarkersBrainGene Regulatory NetworksHumansMicroRNAs

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

30734227

Citation

Swarbrick, S, et al. "Systematic Review of miRNA as Biomarkers in Alzheimer's Disease." Molecular Neurobiology, vol. 56, no. 9, 2019, pp. 6156-6167.
Swarbrick S, Wragg N, Ghosh S, et al. Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Mol Neurobiol. 2019;56(9):6156-6167.
Swarbrick, S., Wragg, N., Ghosh, S., & Stolzing, A. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 56(9), 6156-6167. https://doi.org/10.1007/s12035-019-1500-y
Swarbrick S, et al. Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Mol Neurobiol. 2019;56(9):6156-6167. PubMed PMID: 30734227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. AU - Swarbrick,S, AU - Wragg,N, AU - Ghosh,S, AU - Stolzing,Alexandra, Y1 - 2019/02/08/ PY - 2018/02/12/received PY - 2019/01/18/accepted PY - 2019/2/9/pubmed PY - 2020/1/10/medline PY - 2019/2/9/entrez KW - Alzheimer disease KW - Biomarkers KW - Brain KW - Peripheral blood KW - miRNA SP - 6156 EP - 6167 JF - Molecular neurobiology JO - Mol Neurobiol VL - 56 IS - 9 N2 - Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a progressive decline in cognitive impairment. Small non-coding microRNA (miRNA) sequences have been found to be deregulated in the peripheral blood of Alzheimer patients. A systematic review was conducted to extract all miRNA found to be significantly deregulated in the peripheral blood. These deregulated miRNAs were cross-referenced against the miRNAs deregulated in the brain at Braak Stage III. This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. After network analysis of the 10 miRNAs, they were found to be associated with the immune system, cell cycle, gene expression, cellular response to stress, neuron growth factor signalling, wnt signalling, cellular senescence, and Rho GTPases. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/30734227/Systematic_Review_of_miRNA_as_Biomarkers_in_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -