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Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.
J Formos Med Assoc. 2019 Jun; 118(6):973-978.JF

Abstract

BACKGROUND/PURPOSE

Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

METHODS

Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects.

RESULTS

We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively.

CONCLUSION

Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management.

Authors+Show Affiliations

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30736997

Citation

Chiang, Chun-Pin, et al. "Gastric Parietal Cell and Thyroid Autoantibodies in Patients With Atrophic Glossitis." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 118, no. 6, 2019, pp. 973-978.
Chiang CP, Yu-Fong Chang J, Wang YP, et al. Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. J Formos Med Assoc. 2019;118(6):973-978.
Chiang, C. P., Yu-Fong Chang, J., Wang, Y. P., Wu, Y. H., Wu, Y. C., & Sun, A. (2019). Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 118(6), 973-978. https://doi.org/10.1016/j.jfma.2019.01.016
Chiang CP, et al. Gastric Parietal Cell and Thyroid Autoantibodies in Patients With Atrophic Glossitis. J Formos Med Assoc. 2019;118(6):973-978. PubMed PMID: 30736997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis. AU - Chiang,Chun-Pin, AU - Yu-Fong Chang,Julia, AU - Wang,Yi-Ping, AU - Wu,Yu-Hsueh, AU - Wu,Yang-Che, AU - Sun,Andy, Y1 - 2019/02/05/ PY - 2019/01/15/received PY - 2019/01/21/accepted PY - 2019/2/10/pubmed PY - 2019/11/28/medline PY - 2019/2/10/entrez KW - Atrophic glossitis KW - Gastric parietal cell antibody KW - Thyroglobulin antibody KW - Thyroid microsomal antibody SP - 973 EP - 978 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 118 IS - 6 N2 - BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients. METHODS: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. RESULTS: We found that 26.7%, 28.4%, and 29.8% of 1064 AG patients and 2.3%, 2.1%, and 2.6% of 532 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. AG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). We also found that 67 (6.3%), 181 (17.0%), and 340 (32.0%) AG patients and 3 (0.6%), 10 (1.9%), and 8 (1.5%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 373 TGA/TMA-positive AG patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 78.6%, 8.0%, and 13.4% of these TGA/TMA-positive AG patients had normal, lower, and higher serum TSH levels, respectively. CONCLUSION: Approximately 55.3% of 1064 AG patients have serum GPCA/TGA/TMA positivity. Because part of GPCA-positive AG patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive AG patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these autoantibody-positive AG patients should be referred to medical doctors for further management. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/30736997/Gastric_parietal_cell_and_thyroid_autoantibodies_in_patients_with_atrophic_glossitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(19)30049-X DB - PRIME DP - Unbound Medicine ER -