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GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus.
J Antibiot (Tokyo). 2019 04; 72(4):237-240.JA

Abstract

Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 μg ml-1.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Qi X
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Li X
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhao J
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
He N
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Li Y
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhang T
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Wang S
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yu L
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. yly@cpcc.ac.cn.
Xie Y
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. xieyy@imb.pumc.edu.cn.

MeSH

AlkaloidsAnti-Bacterial AgentsCulture MediaEndophytesMagnetic Resonance SpectroscopyMass SpectrometryMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructurePenicillium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30737454

Citation

Qi, Xin, et al. "GKK1032C, a New Alkaloid Compound From the Endophytic Fungus Penicillium Sp. CPCC 400817 With Activity Against Methicillin-resistant S. Aureus." The Journal of Antibiotics, vol. 72, no. 4, 2019, pp. 237-240.
Qi X, Li X, Zhao J, et al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019;72(4):237-240.
Qi, X., Li, X., Zhao, J., He, N., Li, Y., Zhang, T., Wang, S., Yu, L., & Xie, Y. (2019). GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. The Journal of Antibiotics, 72(4), 237-240. https://doi.org/10.1038/s41429-019-0144-5
Qi X, et al. GKK1032C, a New Alkaloid Compound From the Endophytic Fungus Penicillium Sp. CPCC 400817 With Activity Against Methicillin-resistant S. Aureus. J Antibiot (Tokyo). 2019;72(4):237-240. PubMed PMID: 30737454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. AU - Qi,Xin, AU - Li,Xiaoqian, AU - Zhao,Jianyuan, AU - He,Ning, AU - Li,Yihong, AU - Zhang,Tao, AU - Wang,Shanshan, AU - Yu,Liyan, AU - Xie,Yunying, Y1 - 2019/02/08/ PY - 2018/12/06/received PY - 2019/01/12/accepted PY - 2018/12/24/revised PY - 2019/2/10/pubmed PY - 2019/4/30/medline PY - 2019/2/10/entrez SP - 237 EP - 240 JF - The Journal of antibiotics JO - J Antibiot (Tokyo) VL - 72 IS - 4 N2 - Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 μg ml-1. SN - 1881-1469 UR - https://www.unboundmedicine.com/medline/citation/30737454/GKK1032C_a_new_alkaloid_compound_from_the_endophytic_fungus_Penicillium_sp__CPCC_400817_with_activity_against_methicillin_resistant_S__aureus_ DB - PRIME DP - Unbound Medicine ER -