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[Etiologyical Analysis of 133 Patients with Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests].

Abstract

OBJECTIVE

To study the etiology of macrocytic anemia in elderly patients and to evaluate the diagnostic significance of laborotory tests.

METHODS

133 elderly macrocytic anemia patients, whose age>60 years old, hemoglobin<100 g/L, mean red cell volume(MCV)>100 fL, and bone marrow cell test was performed, and these patients were grouped according to diseases, and the bilirubin, lactate dehydrogenase, folic acid, vit B12 and serum ferritin were tested, then the results of tests were compared and analyzed.

RESULTS

The majority of the cases were diagnosed as megaloblastic anemia (MA), myelodysplasia syndrome (MDS), acute leukemia/multiple myeloma (AL/MM) and hemolytic anemia (HA). Usually HA was a simple anemia, while others were accompanied by decrease of other 1 or 2 series. HA patients were often with significant high level of well volume (MCV), red cell distribution width(RDW), reticulocytes (RC) and indirect bilirubin (IBIL) (P<0.01). However, MA patients were often with high level of LDH. Serum ferritin (SF) level was significantly higher in both MDS and AL/MM groups (P<0.01).

CONCLUSION

Common causes of macrocytic anemia in elderly patients are MA, MDS, AL/MM and HA. The combination detection of MCV, RDW, RC, LDH, IBIL and SF contributes to enhancing the accuracy of diagnosis.

Authors+Show Affiliations

Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.E-mail: dlmulijun@163.com.Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30738471

Citation

Zhou, Dong, et al. "[Etiologyical Analysis of 133 Patients With Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 27, no. 1, 2019, pp. 202-207.
Zhou D, Mu LJ, Zhang Q, et al. [Etiologyical Analysis of 133 Patients with Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(1):202-207.
Zhou, D., Mu, L. J., Zhang, Q., Huang, D., & Chen, X. Y. (2019). [Etiologyical Analysis of 133 Patients with Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 27(1), pp. 202-207. doi:10.7534/j.issn.1009-2137.2019.01.033.
Zhou D, et al. [Etiologyical Analysis of 133 Patients With Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(1):202-207. PubMed PMID: 30738471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Etiologyical Analysis of 133 Patients with Elderly Macrocytic Anemia and Diagnostic Significance of Laboratory Tests]. AU - Zhou,Dong, AU - Mu,Li-Jun, AU - Zhang,Qi, AU - Huang,Dan, AU - Chen,Xue-Yu, PY - 2019/2/11/entrez PY - 2019/2/11/pubmed PY - 2019/4/5/medline SP - 202 EP - 207 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 27 IS - 1 N2 - OBJECTIVE: To study the etiology of macrocytic anemia in elderly patients and to evaluate the diagnostic significance of laborotory tests. METHODS: 133 elderly macrocytic anemia patients, whose age>60 years old, hemoglobin<100 g/L, mean red cell volume(MCV)>100 fL, and bone marrow cell test was performed, and these patients were grouped according to diseases, and the bilirubin, lactate dehydrogenase, folic acid, vit B12 and serum ferritin were tested, then the results of tests were compared and analyzed. RESULTS: The majority of the cases were diagnosed as megaloblastic anemia (MA), myelodysplasia syndrome (MDS), acute leukemia/multiple myeloma (AL/MM) and hemolytic anemia (HA). Usually HA was a simple anemia, while others were accompanied by decrease of other 1 or 2 series. HA patients were often with significant high level of well volume (MCV), red cell distribution width(RDW), reticulocytes (RC) and indirect bilirubin (IBIL) (P<0.01). However, MA patients were often with high level of LDH. Serum ferritin (SF) level was significantly higher in both MDS and AL/MM groups (P<0.01). CONCLUSION: Common causes of macrocytic anemia in elderly patients are MA, MDS, AL/MM and HA. The combination detection of MCV, RDW, RC, LDH, IBIL and SF contributes to enhancing the accuracy of diagnosis. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/30738471/[Etiologyical_Analysis_of_133_Patients_with_Elderly_Macrocytic_Anemia_and_Diagnostic_Significance_of_Laboratory_Tests]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -