Tags

Type your tag names separated by a space and hit enter

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.
Front Neurosci 2019; 13:1FN

Abstract

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B12 (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Besides, long-term hypergastrinemia arising from achlorhydria in autoimmune gastritis is associated with neuroendocrine tumors (NETs). Patients diagnosed with SCD coexistent with PA and NET are seldomly reported. We describe a 34-year-old woman with an initial complaint of progressive fatigue, weakness and numbness in her limbs and disturbed gait. Physical examination revealed appearance of anemia, ataxia, decrease of superficial and deep sense, and positive Babinski's sign. Laboratory tests disclosed macrocytic anemia, elevated intrinsic factor antibody and spinal MRI showed extensive T2-weighted hyperintensity in the dorsal columns. A gastric polyp was revealed by gastroscopy and histology showed an NET in the background of severe atrophic gastritis. Symptoms of the patient were relieved by a multidisciplinary therapy. In patients with SCD, PA should be suspected and prompt further investigations to elucidate causes and direct treatment.

Authors+Show Affiliations

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Dermatology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30740042

Citation

Zhang, Nan, et al. "Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused By Autoimmune Gastritis." Frontiers in Neuroscience, vol. 13, 2019, p. 1.
Zhang N, Li RH, Ma L, et al. Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. Front Neurosci. 2019;13:1.
Zhang, N., Li, R. H., Ma, L., Li, N., Shan, P. Y., Wang, X. B., & Liu, A. F. (2019). Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. Frontiers in Neuroscience, 13, p. 1. doi:10.3389/fnins.2019.00001.
Zhang N, et al. Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused By Autoimmune Gastritis. Front Neurosci. 2019;13:1. PubMed PMID: 30740042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. AU - Zhang,Nan, AU - Li,Rui-Hua, AU - Ma,Lin, AU - Li,Na, AU - Shan,Pei-Yan, AU - Wang,Xing-Bang, AU - Liu,Ai-Fen, Y1 - 2019/01/25/ PY - 2018/09/26/received PY - 2019/01/03/accepted PY - 2019/2/12/entrez PY - 2019/2/12/pubmed PY - 2019/2/12/medline KW - autoimmune gastritis KW - gastric neuroendocrine tumors KW - pernicious anemia KW - subacute combined degeneration KW - vitamin B12 deficiency SP - 1 EP - 1 JF - Frontiers in neuroscience JO - Front Neurosci VL - 13 N2 - Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B12 (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Besides, long-term hypergastrinemia arising from achlorhydria in autoimmune gastritis is associated with neuroendocrine tumors (NETs). Patients diagnosed with SCD coexistent with PA and NET are seldomly reported. We describe a 34-year-old woman with an initial complaint of progressive fatigue, weakness and numbness in her limbs and disturbed gait. Physical examination revealed appearance of anemia, ataxia, decrease of superficial and deep sense, and positive Babinski's sign. Laboratory tests disclosed macrocytic anemia, elevated intrinsic factor antibody and spinal MRI showed extensive T2-weighted hyperintensity in the dorsal columns. A gastric polyp was revealed by gastroscopy and histology showed an NET in the background of severe atrophic gastritis. Symptoms of the patient were relieved by a multidisciplinary therapy. In patients with SCD, PA should be suspected and prompt further investigations to elucidate causes and direct treatment. SN - 1662-4548 UR - https://www.unboundmedicine.com/medline/citation/30740042/Subacute_Combined_Degeneration,_Pernicious_Anemia_and_Gastric_Neuroendocrine_Tumor_Occured_Simultaneously_Caused_by_Autoimmune_Gastritis L2 - https://doi.org/10.3389/fnins.2019.00001 DB - PRIME DP - Unbound Medicine ER -