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Gastrodin pretreatment alleviates rat brain injury caused by cerebral ischemic-reperfusion.
Brain Res. 2019 06 01; 1712:207-216.BR

Abstract

Brain damage, including blood-brain barrier (BBB) dysfunction, neurological behavior deficit, cerebral infarction and inflammation, is commonly caused by ischemic-reperfusion (I/R) injury. Prevention of the above biological process defects is considered beneficial for patient recovery after I/R injury. This study was aimed to assess the neuroprotective effect of Gastrodin (GAS), an herbal agent, in experimentally induced cerebral ischemia. Sprague-Dawley adult rats were randomly divided into six groups: Sham-operated control group (Sham), middle cerebral artery occlusion (MCAO) group, GAS (50, 100, and 200 mg/kg) pretreatment + MCAO groups (GAS) and Nimodipine (NIM) + MCAO, namely, the NIM group. Additionally, an OGD/R model using BV-2 microglia was established in vitro to simulate I/R injury. We showed here that the neurological scores of rats in the GAS groups were significantly improved compared with the MCAO group. Moreover, the area of cerebral infarction in the GAS pretreatment groups and the NIM group was significantly reduced. Furthermore, Evans blue leakage volume was significantly reduced with GAS pretreatment notably at dose 100 mg/kg. Expression of matrix metalloproteinase 2 (MMP2) and MMP9 in GAS groups was markedly decreased when compared with MCAO group. In BV-2 microglia exposed to OGD/R given GAS pretreatment, MMP2 and MMP9 positive cells were reduced in numbers. The present results have shown that GAS pretreatment significantly compensated for neurological behavior defects in rats with I/R-induced injury, reduced brain infarction size, reversed BBB impairment, and attenuated inflammation. It is suggested that pretreatment with GAS before surgery is beneficial during recovery from I/R injury.

Authors+Show Affiliations

Technology Transfer Center, Kunming Medical University, Kunming 650500, China; Department of Neurosurgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.Technology Transfer Center, Kunming Medical University, Kunming 650500, China.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.Technology Transfer Center, Kunming Medical University, Kunming 650500, China. Electronic address: ludi@kmmu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30742808

Citation

Li, Shipeng, et al. "Gastrodin Pretreatment Alleviates Rat Brain Injury Caused By Cerebral Ischemic-reperfusion." Brain Research, vol. 1712, 2019, pp. 207-216.
Li S, Bian L, Fu X, et al. Gastrodin pretreatment alleviates rat brain injury caused by cerebral ischemic-reperfusion. Brain Res. 2019;1712:207-216.
Li, S., Bian, L., Fu, X., Ai, Q., Sui, Y., Zhang, A., Gao, H., Zhong, L., & Lu, D. (2019). Gastrodin pretreatment alleviates rat brain injury caused by cerebral ischemic-reperfusion. Brain Research, 1712, 207-216. https://doi.org/10.1016/j.brainres.2019.02.006
Li S, et al. Gastrodin Pretreatment Alleviates Rat Brain Injury Caused By Cerebral Ischemic-reperfusion. Brain Res. 2019 06 1;1712:207-216. PubMed PMID: 30742808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrodin pretreatment alleviates rat brain injury caused by cerebral ischemic-reperfusion. AU - Li,Shipeng, AU - Bian,Ligong, AU - Fu,Xiyue, AU - Ai,Qinglong, AU - Sui,Yue, AU - Zhang,Aidan, AU - Gao,Huiqing, AU - Zhong,Lianmei, AU - Lu,Di, Y1 - 2019/02/08/ PY - 2018/12/10/received PY - 2019/02/02/revised PY - 2019/02/07/accepted PY - 2019/2/12/pubmed PY - 2020/9/12/medline PY - 2019/2/12/entrez KW - Brain injury KW - Gastrodin KW - Inflammation KW - Ischemic-reperfusion SP - 207 EP - 216 JF - Brain research JO - Brain Res. VL - 1712 N2 - Brain damage, including blood-brain barrier (BBB) dysfunction, neurological behavior deficit, cerebral infarction and inflammation, is commonly caused by ischemic-reperfusion (I/R) injury. Prevention of the above biological process defects is considered beneficial for patient recovery after I/R injury. This study was aimed to assess the neuroprotective effect of Gastrodin (GAS), an herbal agent, in experimentally induced cerebral ischemia. Sprague-Dawley adult rats were randomly divided into six groups: Sham-operated control group (Sham), middle cerebral artery occlusion (MCAO) group, GAS (50, 100, and 200 mg/kg) pretreatment + MCAO groups (GAS) and Nimodipine (NIM) + MCAO, namely, the NIM group. Additionally, an OGD/R model using BV-2 microglia was established in vitro to simulate I/R injury. We showed here that the neurological scores of rats in the GAS groups were significantly improved compared with the MCAO group. Moreover, the area of cerebral infarction in the GAS pretreatment groups and the NIM group was significantly reduced. Furthermore, Evans blue leakage volume was significantly reduced with GAS pretreatment notably at dose 100 mg/kg. Expression of matrix metalloproteinase 2 (MMP2) and MMP9 in GAS groups was markedly decreased when compared with MCAO group. In BV-2 microglia exposed to OGD/R given GAS pretreatment, MMP2 and MMP9 positive cells were reduced in numbers. The present results have shown that GAS pretreatment significantly compensated for neurological behavior defects in rats with I/R-induced injury, reduced brain infarction size, reversed BBB impairment, and attenuated inflammation. It is suggested that pretreatment with GAS before surgery is beneficial during recovery from I/R injury. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/30742808/Gastrodin_pretreatment_alleviates_rat_brain_injury_caused_by_cerebral_ischemic_reperfusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(19)30082-4 DB - PRIME DP - Unbound Medicine ER -