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Possible effect of hala extract (Pandanus tectorius) on immune status, anti-tumour and resistance to Yersinia ruckeri infection in rainbow trout (Oncorhynchus mykiss).
Fish Shellfish Immunol. 2019 Apr; 87:620-626.FS

Abstract

The possible effect of dietary administration of hala extract (Pandanus tectorius) on rainbow trout (Oncorhynchus mykiss) immune status as well as its effect as an anti-tumour agent was studied. Fish were divided into 4 groups before feeding with commercial diet (0%, control; 0.5%, 1% and 2% of hala extract) for 2 weeks. The effect of diet on the humoral immune parameters, ie total protein, myeloperoxidase content, antiproteases, lysozyme and bactericidal activities were studied. Also, the effect of the diets on the expression of some immune-related genes in rainbow trout head-kidney (TNF, LYZ2, IL-8 and CD-4) as well as tumour suppressor gene (WT-1a) was investigated. At the end of the feeding trial fish groups were challenged with Yersinia ruckeri. The results demonstrated enhancement in all the immune parameters in fish fed hala extract diets compared to control fish especially with the highest dose (2%) which recorded the highest significant increase (p < 0.05) in some parameters (total protein, myeloperoxidase content, antiproteases, and bactericidal activities) compared to the control. The results obtained from challenge with Y. ruckeri revealed reduction in the mortalities in fish groups fed with 1% and 2% doses of hala extract. Feeding with hala extract provoked upregulation in all immune- related genes. Again, the highest dose of hala extract showed a significant upregulation in WT1a expression (p < 0.05). The current study suggest that the hala extract, especially the highest dose, could be considered a good food additive to improve the immune status, resist tumour formation and to resist or control infectious diseases of rainbow trout.

Authors+Show Affiliations

Institute of Life and Earth Sciences, Heriot-Watt University, Edinburgh, UK; Department of Hydrobiology, National Research Center, Cairo, Egypt. Electronic address: elhamsawad@yahoo.com.Institute of Life and Earth Sciences, Heriot-Watt University, Edinburgh, UK.Institute of Life and Earth Sciences, Heriot-Watt University, Edinburgh, UK.Pharmacognosy Department, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30753919

Citation

Awad, Elham, et al. "Possible Effect of Hala Extract (Pandanus Tectorius) On Immune Status, Anti-tumour and Resistance to Yersinia Ruckeri Infection in Rainbow Trout (Oncorhynchus Mykiss)." Fish & Shellfish Immunology, vol. 87, 2019, pp. 620-626.
Awad E, Austin D, Lyndon A, et al. Possible effect of hala extract (Pandanus tectorius) on immune status, anti-tumour and resistance to Yersinia ruckeri infection in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2019;87:620-626.
Awad, E., Austin, D., Lyndon, A., & Awaad, A. (2019). Possible effect of hala extract (Pandanus tectorius) on immune status, anti-tumour and resistance to Yersinia ruckeri infection in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology, 87, 620-626. https://doi.org/10.1016/j.fsi.2019.02.012
Awad E, et al. Possible Effect of Hala Extract (Pandanus Tectorius) On Immune Status, Anti-tumour and Resistance to Yersinia Ruckeri Infection in Rainbow Trout (Oncorhynchus Mykiss). Fish Shellfish Immunol. 2019;87:620-626. PubMed PMID: 30753919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible effect of hala extract (Pandanus tectorius) on immune status, anti-tumour and resistance to Yersinia ruckeri infection in rainbow trout (Oncorhynchus mykiss). AU - Awad,Elham, AU - Austin,Dawn, AU - Lyndon,Alastair, AU - Awaad,Amani, Y1 - 2019/02/10/ PY - 2018/12/10/received PY - 2019/02/06/revised PY - 2019/02/08/accepted PY - 2019/2/13/pubmed PY - 2019/6/27/medline PY - 2019/2/13/entrez KW - Anti-tumour KW - Immune response KW - Pandanus tectorius KW - Rainbow trout KW - Yersinia ruckeri SP - 620 EP - 626 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 87 N2 - The possible effect of dietary administration of hala extract (Pandanus tectorius) on rainbow trout (Oncorhynchus mykiss) immune status as well as its effect as an anti-tumour agent was studied. Fish were divided into 4 groups before feeding with commercial diet (0%, control; 0.5%, 1% and 2% of hala extract) for 2 weeks. The effect of diet on the humoral immune parameters, ie total protein, myeloperoxidase content, antiproteases, lysozyme and bactericidal activities were studied. Also, the effect of the diets on the expression of some immune-related genes in rainbow trout head-kidney (TNF, LYZ2, IL-8 and CD-4) as well as tumour suppressor gene (WT-1a) was investigated. At the end of the feeding trial fish groups were challenged with Yersinia ruckeri. The results demonstrated enhancement in all the immune parameters in fish fed hala extract diets compared to control fish especially with the highest dose (2%) which recorded the highest significant increase (p < 0.05) in some parameters (total protein, myeloperoxidase content, antiproteases, and bactericidal activities) compared to the control. The results obtained from challenge with Y. ruckeri revealed reduction in the mortalities in fish groups fed with 1% and 2% doses of hala extract. Feeding with hala extract provoked upregulation in all immune- related genes. Again, the highest dose of hala extract showed a significant upregulation in WT1a expression (p < 0.05). The current study suggest that the hala extract, especially the highest dose, could be considered a good food additive to improve the immune status, resist tumour formation and to resist or control infectious diseases of rainbow trout. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/30753919/Possible_effect_of_hala_extract__Pandanus_tectorius__on_immune_status_anti_tumour_and_resistance_to_Yersinia_ruckeri_infection_in_rainbow_trout__Oncorhynchus_mykiss__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(19)30086-5 DB - PRIME DP - Unbound Medicine ER -