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Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5.
Pharm Biol. 2019 Dec; 57(1):105-111.PB

Abstract

CONTEXT

Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine.

OBJECTIVE

This study investigates the potency of EP in promoting hair growth in vivo and in vitro.

MATERIALS AND METHODS

C57BL/6N mice were divided into four groups (n = 4) as follows: control (topical treatment of normal saline), topical 3% minoxidil to the dorsal skin of mice for 14 days, and low (1 mg/day) and high (10 mg/day) doses of EP orally administered once a day for 14 days. Dorsal hairs of C57BL/6N mice were depilated to synchronize anagen induction. Hair growth activity was evaluated by gross and microscopic observations. Sections of dorsal skin were stained with haematoxylin and eosin. We also treated the various concentrations of EP (5, 10 and 50 μg/mL) for 24 h on the human dermal papilla cells (HDPs) and examined the effects of EP on the expression of FGF-7 and mTOR signalling.

RESULTS

EP enhanced the induction of anagen in the dorsal skin of mice, characterized by the appearance of inner root sheath along with hair shaft, the emergence of hair shaft through the epidermis. EP increased the expression of FGF-7, while decreased the level of FGF-5 in C57/BL6 mice. EP also increased the expression of FGF-7, activated the mTOR signalling in HDPs.

DISCUSSION AND CONCLUSIONS

These results suggest that EP has a potency to enhance the growth of hair follicle, promoting hair growth through regulation of FGF-7 and FGF-5.

Authors+Show Affiliations

a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.b Jeonju AgroBio-Materials Institute , Jeonju-si , Republic of Korea.b Jeonju AgroBio-Materials Institute , Jeonju-si , Republic of Korea.c Department of Anatomy , College of Korean Medicine, Woosuk University , Wanju , Republic of Korea.d Department of Ophthalmology, Otolaryngology and Dermatology , Korean Medicine Hospital, Pusan National University , Yangsan-si , Republic of Korea.a Division of Applied Medicine, School of Korean Medicine , Pusan National University , Yangsan-si , Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30757935

Citation

Lee, Keun-Hyeun, et al. "Eclipta Prostrata Promotes the Induction of Anagen, Sustains the Anagen Phase Through Regulation of FGF-7 and FGF-5." Pharmaceutical Biology, vol. 57, no. 1, 2019, pp. 105-111.
Lee KH, Choi D, Jeong SI, et al. Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5. Pharm Biol. 2019;57(1):105-111.
Lee, K. H., Choi, D., Jeong, S. I., Kim, S. J., Lee, C. H., Seo, H. S., & Jeong, H. S. (2019). Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5. Pharmaceutical Biology, 57(1), 105-111. https://doi.org/10.1080/13880209.2018.1561729
Lee KH, et al. Eclipta Prostrata Promotes the Induction of Anagen, Sustains the Anagen Phase Through Regulation of FGF-7 and FGF-5. Pharm Biol. 2019;57(1):105-111. PubMed PMID: 30757935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5. AU - Lee,Keun-Hyeun, AU - Choi,Dabin, AU - Jeong,Seung-Il, AU - Kim,Sang-Jun, AU - Lee,Chang Hyun, AU - Seo,Hyung-Sik, AU - Jeong,Han-Sol, PY - 2019/2/14/entrez PY - 2019/2/14/pubmed PY - 2019/3/13/medline KW - Hair follicular cycle KW - human dermal papilla KW - mTOR SP - 105 EP - 111 JF - Pharmaceutical biology JO - Pharm Biol VL - 57 IS - 1 N2 - CONTEXT: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. OBJECTIVE: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. MATERIALS AND METHODS: C57BL/6N mice were divided into four groups (n = 4) as follows: control (topical treatment of normal saline), topical 3% minoxidil to the dorsal skin of mice for 14 days, and low (1 mg/day) and high (10 mg/day) doses of EP orally administered once a day for 14 days. Dorsal hairs of C57BL/6N mice were depilated to synchronize anagen induction. Hair growth activity was evaluated by gross and microscopic observations. Sections of dorsal skin were stained with haematoxylin and eosin. We also treated the various concentrations of EP (5, 10 and 50 μg/mL) for 24 h on the human dermal papilla cells (HDPs) and examined the effects of EP on the expression of FGF-7 and mTOR signalling. RESULTS: EP enhanced the induction of anagen in the dorsal skin of mice, characterized by the appearance of inner root sheath along with hair shaft, the emergence of hair shaft through the epidermis. EP increased the expression of FGF-7, while decreased the level of FGF-5 in C57/BL6 mice. EP also increased the expression of FGF-7, activated the mTOR signalling in HDPs. DISCUSSION AND CONCLUSIONS: These results suggest that EP has a potency to enhance the growth of hair follicle, promoting hair growth through regulation of FGF-7 and FGF-5. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/30757935/Eclipta_prostrata_promotes_the_induction_of_anagen_sustains_the_anagen_phase_through_regulation_of_FGF_7_and_FGF_5_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2018.1561729 DB - PRIME DP - Unbound Medicine ER -