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Hypothalamic Control of Conspecific Self-Defense.
Cell Rep. 2019 02 12; 26(7):1747-1758.e5.CR

Abstract

Active defense against a conspecific aggressor is essential for survival. Previous studies revealed strong c-Fos expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl) in defeated animals. Here, we examined the functional relevance and in vivo responses of the VMHvl during conspecific defense. We found that VMHvl cells expressing estrogen receptor α (Esr1) are acutely excited during active conspecific defense. Optogenetic inhibition of the cells compromised an animal's ability to actively defend against an aggressor, whereas activating the cells elicited defense-like behaviors. Furthermore, the VMHvl is known for its role in aggression. In vivo recording and c-Fos mapping revealed differential organization of the defense and aggression-responsive cells in the VMHvl. Specifically, defense-activated cells are concentrated in the anterior part of the VMHvl, which preferentially targets the periaqueductal gray (PAG). Thus, our study identified an essential neural substrate for active conspecific defense and expanded the function of the VMHvl.

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Authors+Show Affiliations

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; School of Life Sciences, Peking University, Beijing 100871, China.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: dayu.lin@nyulangone.org.

MeSH

AggressionAnimalsHypothalamusMaleMiceSocial Behavior

Pub Type(s)

Journal Article

Research Support, N.I.H., Extramural

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30759387

Citation

Wang, Li, et al. "Hypothalamic Control of Conspecific Self-Defense." Cell Reports, vol. 26, no. 7, 2019, pp. 1747-1758.e5.

Wang L, Talwar V, Osakada T, et al. Hypothalamic Control of Conspecific Self-Defense. Cell Rep. 2019;26(7):1747-1758.e5.

Wang, L., Talwar, V., Osakada, T., Kuang, A., Guo, Z., Yamaguchi, T., & Lin, D. (2019). Hypothalamic Control of Conspecific Self-Defense. Cell Reports, 26(7), 1747-e5. https://doi.org/10.1016/j.celrep.2019.01.078

Wang L, et al. Hypothalamic Control of Conspecific Self-Defense. Cell Rep. 2019 02 12;26(7):1747-1758.e5. PubMed PMID: 30759387.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Hypothalamic Control of Conspecific Self-Defense. AU - Wang,Li, AU - Talwar,Vaishali, AU - Osakada,Takuya, AU - Kuang,Amy, AU - Guo,Zhichao, AU - Yamaguchi,Takashi, AU - Lin,Dayu, PY - 2018/07/21/received PY - 2018/12/03/revised PY - 2019/01/19/accepted PY - 2019/2/14/entrez PY - 2019/2/14/pubmed PY - 2020/4/22/medline KW - aggression KW - estrogen receptor alpha KW - neural circuit KW - self-defense KW - ventromedial hypothalamus SP - 1747 EP - 1758.e5 JF - Cell reports JO - Cell Rep VL - 26 IS - 7 N2 - Active defense against a conspecific aggressor is essential for survival. Previous studies revealed strong c-Fos expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl) in defeated animals. Here, we examined the functional relevance and in vivo responses of the VMHvl during conspecific defense. We found that VMHvl cells expressing estrogen receptor α (Esr1) are acutely excited during active conspecific defense. Optogenetic inhibition of the cells compromised an animal's ability to actively defend against an aggressor, whereas activating the cells elicited defense-like behaviors. Furthermore, the VMHvl is known for its role in aggression. In vivo recording and c-Fos mapping revealed differential organization of the defense and aggression-responsive cells in the VMHvl. Specifically, defense-activated cells are concentrated in the anterior part of the VMHvl, which preferentially targets the periaqueductal gray (PAG). Thus, our study identified an essential neural substrate for active conspecific defense and expanded the function of the VMHvl. SN - 2211-1247 UR - https://www.unboundmedicine.com/medline/citation/30759387/Hypothalamic_Control_of_Conspecific_Self_Defense_ DB - PRIME DP - Unbound Medicine ER -