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Frequency and Implications of myeloid-derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma.
J Med Virol. 2019 07; 91(7):1319-1328.JM

Abstract

BACKGROUND AND AIM

Myeloid-derived suppressor cells (MDSCs) play a pivotal role in tumor immunity and induction of immune tolerance to a variety of antitumor effectors, including T lymphocytes. Herein, we tried to evaluate the frequency and clinical significance of MDSCs and different lymphocyte subsets in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).

METHODS

Four groups were enrolled; chronic HCV (CHC; n = 40), HCV-related liver cirrhosis (n = 40), HCV-related HCC (HCV-HCC; n = 75), and healthy control group (n = 20). The percentage of peripheral lymphocytes subsets and total MDSCs with their main two subsets; monocytic (M-MDSCs) and granulocytic (G-MDSCs) was evaluated by flow cytometry.

RESULTS

The frequency of total MSDCs and M-MDSCs was significantly elevated in HCV-HCC especially patients with advanced stage HCC compared with those with early-stage HCC. The frequency of total MSDCs and M-MDSCs was positively correlated with ALT, AFP, and HCV viral load and negatively correlated with CD8+ T-cell frequency. CD4 + T cells were significantly decreased in HCV-HCC patients. The frequency of CD4 + T cells and CD8 + T cells was negatively correlated with AFP and AST, but not with albumin or HCV viral load.

CONCLUSION

Taken together, our data suggest that MDSCs, M-MDSCs, and lymphocyte subsets are associated with the development and progression of HCV-related HCC.

Authors+Show Affiliations

Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt.Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt.Department of Tropical Medicine and Gastroenterology, Assiut University Hospital, Assiut, Egypt.Department of Tropical Medicine and Gastroenterology, Assiut University Hospital, Assiut, Egypt.Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30761547

Citation

Hetta, Helal F., et al. "Frequency and Implications of Myeloid-derived Suppressor Cells and Lymphocyte Subsets in Egyptian Patients With Hepatitis C Virus-related Hepatocellular Carcinoma." Journal of Medical Virology, vol. 91, no. 7, 2019, pp. 1319-1328.
Hetta HF, Zahran AM, Mansor SG, et al. Frequency and Implications of myeloid-derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. J Med Virol. 2019;91(7):1319-1328.
Hetta, H. F., Zahran, A. M., Mansor, S. G., Abdel-Malek, M. O., Mekky, M. A., & Abbas, W. A. (2019). Frequency and Implications of myeloid-derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. Journal of Medical Virology, 91(7), 1319-1328. https://doi.org/10.1002/jmv.25428
Hetta HF, et al. Frequency and Implications of Myeloid-derived Suppressor Cells and Lymphocyte Subsets in Egyptian Patients With Hepatitis C Virus-related Hepatocellular Carcinoma. J Med Virol. 2019;91(7):1319-1328. PubMed PMID: 30761547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency and Implications of myeloid-derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. AU - Hetta,Helal F, AU - Zahran,Asmaa M, AU - Mansor,Shima G, AU - Abdel-Malek,Mohamed O, AU - Mekky,Mohamed A, AU - Abbas,Wael A, Y1 - 2019/02/25/ PY - 2018/11/01/received PY - 2019/01/26/revised PY - 2019/02/07/accepted PY - 2019/2/15/pubmed PY - 2020/4/10/medline PY - 2019/2/15/entrez KW - hepatitis C Virus (HCV) KW - hepatocellular carcinoma (HCC) KW - lymphocytes KW - myeloid-derived suppressor cells SP - 1319 EP - 1328 JF - Journal of medical virology JO - J. Med. Virol. VL - 91 IS - 7 N2 - BACKGROUND AND AIM: Myeloid-derived suppressor cells (MDSCs) play a pivotal role in tumor immunity and induction of immune tolerance to a variety of antitumor effectors, including T lymphocytes. Herein, we tried to evaluate the frequency and clinical significance of MDSCs and different lymphocyte subsets in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Four groups were enrolled; chronic HCV (CHC; n = 40), HCV-related liver cirrhosis (n = 40), HCV-related HCC (HCV-HCC; n = 75), and healthy control group (n = 20). The percentage of peripheral lymphocytes subsets and total MDSCs with their main two subsets; monocytic (M-MDSCs) and granulocytic (G-MDSCs) was evaluated by flow cytometry. RESULTS: The frequency of total MSDCs and M-MDSCs was significantly elevated in HCV-HCC especially patients with advanced stage HCC compared with those with early-stage HCC. The frequency of total MSDCs and M-MDSCs was positively correlated with ALT, AFP, and HCV viral load and negatively correlated with CD8+ T-cell frequency. CD4 + T cells were significantly decreased in HCV-HCC patients. The frequency of CD4 + T cells and CD8 + T cells was negatively correlated with AFP and AST, but not with albumin or HCV viral load. CONCLUSION: Taken together, our data suggest that MDSCs, M-MDSCs, and lymphocyte subsets are associated with the development and progression of HCV-related HCC. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/30761547/Frequency_and_Implications_of_myeloid_derived_suppressor_cells_and_lymphocyte_subsets_in_Egyptian_patients_with_hepatitis_C_virus_related_hepatocellular_carcinoma_ L2 - https://doi.org/10.1002/jmv.25428 DB - PRIME DP - Unbound Medicine ER -