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Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis.
Acta Ophthalmol. 2019 Aug; 97(5):e780-e784.AO

Abstract

PURPOSE

Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor-α (TNF-α) and IL-1β.

METHODS

Aqueous humour (AH) samples from patients with active uveitis associated with Behçet's disease (BD; n = 13), sarcoidosis (n = 8), human leucocyte antigen (HLA)-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control subjects (n = 9) were assayed with the use of a multiplex assay.

RESULTS

Of all the IL-10 family cytokines studied, only IL-19 levels were significantly higher in AH samples of patients (n = 45) than in controls (p = 0.022). When comparing the four individual disease groups to controls, IL-19 levels were only significantly higher in HLA-B27-associated uveitis (p < 0.001). IL-19 levels were significantly higher in patients with HLA-B27-associated uveitis than in patients with BD, sarcoidosis and VKH disease (p < 0.001; p = 0.002; p < 0.001, respectively). Significant correlations were found between AH levels of IL-19 and AH levels of TNF-α, (r = 0.3; p = 0.03) and IL-1β (r = 0.56; p < 0.001).

CONCLUSIONS

Among the IL-10 family cytokines analysed, IL-19 demonstrated the highest expression in endogenous uveitis, particularly in HLA-B27-associated uveitis. IL-19 thus might assist in the regulation of inflammation in HLA-B27-associated uveitis.

Authors+Show Affiliations

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Dr. Nasser Al-Rashid Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30761764

Citation

Abu El-Asrar, Ahmed M., et al. "Expression of Interleukin (IL)-10 Family Cytokines in Aqueous Humour of Patients With Specific Endogenous Uveitic Entities: Elevated Levels of IL-19 in Human Leucocyte antigen-B27-associated Uveitis." Acta Ophthalmologica, vol. 97, no. 5, 2019, pp. e780-e784.
Abu El-Asrar AM, Berghmans N, Al-Obeidan SA, et al. Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis. Acta Ophthalmol. 2019;97(5):e780-e784.
Abu El-Asrar, A. M., Berghmans, N., Al-Obeidan, S. A., Gikandi, P. W., Opdenakker, G., Van Damme, J., & Struyf, S. (2019). Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis. Acta Ophthalmologica, 97(5), e780-e784. https://doi.org/10.1111/aos.14039
Abu El-Asrar AM, et al. Expression of Interleukin (IL)-10 Family Cytokines in Aqueous Humour of Patients With Specific Endogenous Uveitic Entities: Elevated Levels of IL-19 in Human Leucocyte antigen-B27-associated Uveitis. Acta Ophthalmol. 2019;97(5):e780-e784. PubMed PMID: 30761764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis. AU - Abu El-Asrar,Ahmed M, AU - Berghmans,Nele, AU - Al-Obeidan,Saleh A, AU - Gikandi,Priscilla W, AU - Opdenakker,Ghislain, AU - Van Damme,Jo, AU - Struyf,Sofie, Y1 - 2019/02/13/ PY - 2018/06/16/received PY - 2018/12/06/accepted PY - 2019/2/15/pubmed PY - 2019/7/19/medline PY - 2019/2/15/entrez KW - aqueous humour KW - interleukin-10 family cytokines KW - interleukin-19 KW - uveitis SP - e780 EP - e784 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 97 IS - 5 N2 - PURPOSE: Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor-α (TNF-α) and IL-1β. METHODS: Aqueous humour (AH) samples from patients with active uveitis associated with Behçet's disease (BD; n = 13), sarcoidosis (n = 8), human leucocyte antigen (HLA)-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control subjects (n = 9) were assayed with the use of a multiplex assay. RESULTS: Of all the IL-10 family cytokines studied, only IL-19 levels were significantly higher in AH samples of patients (n = 45) than in controls (p = 0.022). When comparing the four individual disease groups to controls, IL-19 levels were only significantly higher in HLA-B27-associated uveitis (p < 0.001). IL-19 levels were significantly higher in patients with HLA-B27-associated uveitis than in patients with BD, sarcoidosis and VKH disease (p < 0.001; p = 0.002; p < 0.001, respectively). Significant correlations were found between AH levels of IL-19 and AH levels of TNF-α, (r = 0.3; p = 0.03) and IL-1β (r = 0.56; p < 0.001). CONCLUSIONS: Among the IL-10 family cytokines analysed, IL-19 demonstrated the highest expression in endogenous uveitis, particularly in HLA-B27-associated uveitis. IL-19 thus might assist in the regulation of inflammation in HLA-B27-associated uveitis. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/30761764/Expression_of_interleukin__IL__10_family_cytokines_in_aqueous_humour_of_patients_with_specific_endogenous_uveitic_entities:_elevated_levels_of_IL_19_in_human_leucocyte_antigen_B27_associated_uveitis_ L2 - https://doi.org/10.1111/aos.14039 DB - PRIME DP - Unbound Medicine ER -