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Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis.
Medicine (Baltimore) 2019; 98(7):e14324M

Abstract

OBJECTIVE

This meta-analysis is to investigate the relationship between the patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 polymorphism and the susceptibility and severity of nonalcoholic fatty liver disease (NAFLD).

METHODS

Chinese Journal Full-text Database, Wanfang Database, VIP Database, and PubMed Database were subjected to case-control study retrieving, from January 2008 to December 2014. Following key words were used: fatty liver, PNPLA3, and rs738409 gene or variants or polymorphism or alleles. Meta-analysis was performed based on the retrieved articles.

RESULTS

In total 65 studies were first retrieved according to the key words, and finally 21 studies with 14,266 subjects were included. Meta-analysis showed that PNPLA3 rs738409 polymorphism exerted strong influence not only on fatty liver but also on the histological injury. PNPLA3 rs738409 [G] allele was a risk factor for NAFLD (GG vs CC, OR = 4.01, 95% CI 2.93-5.49; GC vs CC, OR = 1.88, 95% CI 1.58-2.24). PNPLA3 gene variant was significantly associated with the increased serum alanine aminotransferase (ALT) levels (GG vs CC, standardized mean difference = 0.47, 95% CI 0.14-0.81). In addition, nonalcoholic steatohepatitis (NASH) was more frequently observed in G allele carriers (GG vs CC, OR = 3.24, 95% CI 2.79-3.76; GC vs CC, OR = 2.14, 95% CI 1.43-3.19).

CONCLUSION

PNPLA3 rs738409 polymorphism is not only a factor significantly associated with the susceptibility of NAFLD, but also related to the susceptibility of aggressive diseases.

Authors+Show Affiliations

Department of Gastroenterology, Yanan University Affiliated Hospital, Yanan. Department of Gastroenterology, Xi'an Jiaotong University First Affiliated Hospital, Xi'an, Shaanxi, China.Department of Gastroenterology, Yanan University Affiliated Hospital, Yanan.Department of Gastroenterology, Yanan University Affiliated Hospital, Yanan.Department of Gastroenterology, Xi'an Jiaotong University First Affiliated Hospital, Xi'an, Shaanxi, China.Department of Gastroenterology, Xi'an Jiaotong University First Affiliated Hospital, Xi'an, Shaanxi, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

30762732

Citation

Dai, Guangrong, et al. "Association Between PNPLA3 Rs738409 Polymorphism and Nonalcoholic Fatty Liver Disease (NAFLD) Susceptibility and Severity: a Meta-analysis." Medicine, vol. 98, no. 7, 2019, pp. e14324.
Dai G, Liu P, Li X, et al. Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis. Medicine (Baltimore). 2019;98(7):e14324.
Dai, G., Liu, P., Li, X., Zhou, X., & He, S. (2019). Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis. Medicine, 98(7), pp. e14324. doi:10.1097/MD.0000000000014324.
Dai G, et al. Association Between PNPLA3 Rs738409 Polymorphism and Nonalcoholic Fatty Liver Disease (NAFLD) Susceptibility and Severity: a Meta-analysis. Medicine (Baltimore). 2019;98(7):e14324. PubMed PMID: 30762732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis. AU - Dai,Guangrong, AU - Liu,Pengfei, AU - Li,Xiaomei, AU - Zhou,Xiaoyan, AU - He,Shuixiang, PY - 2019/2/15/entrez PY - 2019/2/15/pubmed PY - 2019/3/15/medline SP - e14324 EP - e14324 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 7 N2 - OBJECTIVE: This meta-analysis is to investigate the relationship between the patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 polymorphism and the susceptibility and severity of nonalcoholic fatty liver disease (NAFLD). METHODS: Chinese Journal Full-text Database, Wanfang Database, VIP Database, and PubMed Database were subjected to case-control study retrieving, from January 2008 to December 2014. Following key words were used: fatty liver, PNPLA3, and rs738409 gene or variants or polymorphism or alleles. Meta-analysis was performed based on the retrieved articles. RESULTS: In total 65 studies were first retrieved according to the key words, and finally 21 studies with 14,266 subjects were included. Meta-analysis showed that PNPLA3 rs738409 polymorphism exerted strong influence not only on fatty liver but also on the histological injury. PNPLA3 rs738409 [G] allele was a risk factor for NAFLD (GG vs CC, OR = 4.01, 95% CI 2.93-5.49; GC vs CC, OR = 1.88, 95% CI 1.58-2.24). PNPLA3 gene variant was significantly associated with the increased serum alanine aminotransferase (ALT) levels (GG vs CC, standardized mean difference = 0.47, 95% CI 0.14-0.81). In addition, nonalcoholic steatohepatitis (NASH) was more frequently observed in G allele carriers (GG vs CC, OR = 3.24, 95% CI 2.79-3.76; GC vs CC, OR = 2.14, 95% CI 1.43-3.19). CONCLUSION: PNPLA3 rs738409 polymorphism is not only a factor significantly associated with the susceptibility of NAFLD, but also related to the susceptibility of aggressive diseases. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/30762732/Association_between_PNPLA3_rs738409_polymorphism_and_nonalcoholic_fatty_liver_disease__NAFLD__susceptibility_and_severity:_A_meta_analysis_ L2 - http://Insights.ovid.com/pubmed?pmid=30762732 DB - PRIME DP - Unbound Medicine ER -