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The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016.
BMC Musculoskelet Disord. 2019 Feb 14; 20(1):78.BM

Abstract

BACKGROUND

Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China.

METHODS

For this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool.

RESULTS

A total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8-15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6-17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7-20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5-12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD.

CONCLUSIONS

Our systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD.

Authors+Show Affiliations

School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China. Xi'an Jiaotong University Global Health Institutes, No.76 Yanta West Road, Xi'an, 710061, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China.School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, No.76 Yanta West Road, 710061, Xi'an, People's Republic of China. guox@xjtu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30764809

Citation

Wang, Xi, et al. "The Systematic Review and Meta-analysis of X-ray Detective Rate of Kashin-Beck Disease From 1992 to 2016." BMC Musculoskeletal Disorders, vol. 20, no. 1, 2019, p. 78.
Wang X, Ning Y, Liu A, et al. The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. BMC Musculoskelet Disord. 2019;20(1):78.
Wang, X., Ning, Y., Liu, A., Qi, X., Liu, M., Zhang, P., & Guo, X. (2019). The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. BMC Musculoskeletal Disorders, 20(1), 78. https://doi.org/10.1186/s12891-019-2461-z
Wang X, et al. The Systematic Review and Meta-analysis of X-ray Detective Rate of Kashin-Beck Disease From 1992 to 2016. BMC Musculoskelet Disord. 2019 Feb 14;20(1):78. PubMed PMID: 30764809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016. AU - Wang,Xi, AU - Ning,Yujie, AU - Liu,Amin, AU - Qi,Xin, AU - Liu,Meidan, AU - Zhang,Pan, AU - Guo,Xiong, Y1 - 2019/02/14/ PY - 2018/04/23/received PY - 2019/02/07/accepted PY - 2019/2/16/entrez PY - 2019/2/16/pubmed PY - 2019/5/29/medline KW - Correlation analysis KW - Kashin-Beck disease KW - Meta-analysis KW - X-ray detective rate SP - 78 EP - 78 JF - BMC musculoskeletal disorders JO - BMC Musculoskelet Disord VL - 20 IS - 1 N2 - BACKGROUND: Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China. METHODS: For this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool. RESULTS: A total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8-15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6-17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7-20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5-12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD. CONCLUSIONS: Our systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD. SN - 1471-2474 UR - https://www.unboundmedicine.com/medline/citation/30764809/The_systematic_review_and_meta_analysis_of_X_ray_detective_rate_of_Kashin_Beck_disease_from_1992_to_2016_ L2 - https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-019-2461-z DB - PRIME DP - Unbound Medicine ER -