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Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria.
Trans R Soc Trop Med Hyg. 1988; 82(4):538-40.TR

Abstract

Three different doses of a combination of mefloquine-sulfadoxine-pyrimethamine (MSP), given double-blind as a single dose to 60 children, were evaluated for efficacy and tolerance. The children, 42 boys and 18 girls aged between 5 and 15 years, received a mefloquine dose equivalent to 1, 1.5, or 2 standard MSP (Fansimef) tablets. Radical cure was obtained in all patients with only mild to moderate side effects of nausea and vomiting, which were not worse in the higher dose groups. For children living in an endemic malarious area, a single dose of mefloquine 7.1-12.5 mg/kg, given in combination with sulfadoxine (14.3-25.0 mg/kg) and pyrimethamine (0.7-1.3 mg/kg), is a safe and effective treatment for uncomplicated chloroquine-resistant Plasmodium falciparum malaria. This dose of MSP is approximately 10 mg/kg, 20 mg/kg and 1.0 mg/kg respectively of mefloquine, sulfadoxine and pyrimethamine, which is equivalent to a single standard tablet of Fansimef (mefloquine, 250 mg; sulfadoxine, 500 mg; pyrimethamine, 25 mg) given to a child weighing 20-30 kg.

Authors+Show Affiliations

Guo XB
Malaria Research Unit, Guangzhou College of Traditional Chinese Medicine, Guangdong.
Arnold K
No affiliation info available
Fu LC
No affiliation info available
Chen PQ
No affiliation info available
Li GQ
No affiliation info available

MeSH

AdolescentAnimalsAntimalarialsChildChild, PreschoolClinical Trials as TopicDouble-Blind MethodDrug CombinationsFemaleHumansMalariaMaleMefloquinePlasmodium falciparumPyrimethamineQuinolinesSulfadoxineSulfanilamides

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3076709

Citation

Guo, X B., et al. "Double-blind Dose Finding Study of Mefloquine-sulfadoxine-pyrimethamine in Children With Acute Falciparum Malaria." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 82, no. 4, 1988, pp. 538-40.
Guo XB, Arnold K, Fu LC, et al. Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria. Trans R Soc Trop Med Hyg. 1988;82(4):538-40.
Guo, X. B., Arnold, K., Fu, L. C., Chen, P. Q., & Li, G. Q. (1988). Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 82(4), 538-40.
Guo XB, et al. Double-blind Dose Finding Study of Mefloquine-sulfadoxine-pyrimethamine in Children With Acute Falciparum Malaria. Trans R Soc Trop Med Hyg. 1988;82(4):538-40. PubMed PMID: 3076709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria. AU - Guo,X B, AU - Arnold,K, AU - Fu,L C, AU - Chen,P Q, AU - Li,G Q, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 538 EP - 40 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 82 IS - 4 N2 - Three different doses of a combination of mefloquine-sulfadoxine-pyrimethamine (MSP), given double-blind as a single dose to 60 children, were evaluated for efficacy and tolerance. The children, 42 boys and 18 girls aged between 5 and 15 years, received a mefloquine dose equivalent to 1, 1.5, or 2 standard MSP (Fansimef) tablets. Radical cure was obtained in all patients with only mild to moderate side effects of nausea and vomiting, which were not worse in the higher dose groups. For children living in an endemic malarious area, a single dose of mefloquine 7.1-12.5 mg/kg, given in combination with sulfadoxine (14.3-25.0 mg/kg) and pyrimethamine (0.7-1.3 mg/kg), is a safe and effective treatment for uncomplicated chloroquine-resistant Plasmodium falciparum malaria. This dose of MSP is approximately 10 mg/kg, 20 mg/kg and 1.0 mg/kg respectively of mefloquine, sulfadoxine and pyrimethamine, which is equivalent to a single standard tablet of Fansimef (mefloquine, 250 mg; sulfadoxine, 500 mg; pyrimethamine, 25 mg) given to a child weighing 20-30 kg. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/3076709/Double_blind_dose_finding_study_of_mefloquine_sulfadoxine_pyrimethamine_in_children_with_acute_falciparum_malaria_ DB - PRIME DP - Unbound Medicine ER -