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Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis.
Sci Total Environ. 2019 May 10; 664:874-884.ST

Abstract

Opioids, both as prescription drugs and abuse substances, have been a hot topic and a focus of discussion in the media for the last few years. Although the literature published shows the occurrence of opioids and some of their metabolites in the aquatic environment, there are scarce data in the application of high resolution mass spectrometry (HRMS) for the analysis of these compounds in the environment. The use of HRMS allows increasing the number of opioids that can be studied as well as the detection of unknown opioids, their metabolites and potential transformation products. In this work, a retrospective analysis for the identification of opioids and their metabolites using a curated database was applied to surface water and wastewater samples taken in the state of Minnesota (U.S.) in 2009, which were previously analyzed by liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for antidepressants. The database comprised >200 opioids including natural opiates (e.g. morphine and codeine), their semi-synthetic derivatives (e.g. heroin, hydromorphone, hydrocodone, oxycodone, oxymorphone, meperidine and buprenorphine), fully synthetic opioids (e.g. fentanyl, methadone, tramadol, dextromethorphan and propoxyphene), as well as some of their metabolites (e.g. 6-monoacetylcodeine, dextrorphan, EDDP, normorphine and O-desmethyltramadol). Moreover, additional MS-MS experiments were performed to confirm their identification, as well as to recognize fragmentation patterns and diagnostic ions for several opioids. These data provide a better understanding of the historical occurrence of opioids and their metabolites in surface waters impacted by wastewater sources. The concentrations of individual opioids in surface water and wastewater effluent varied from 8.8 (EDDP) to 1640 (tramadol) ngL-1 and from 12 (dihydrocodeine) to 1288 (tramadol) ngL-1, respectively. The opioids with higher overall frequency detections were tramadol, dextromethorphan and its metabolite, dextrorphan.

Authors+Show Affiliations

Solar Energy Research Centre (CIESOL), Joint Centre University of Almería-CIEMAT, Ctra de Sacramento s/n, 04120 Almería, Spain.Center for Environmental Mass Spectrometry, Dpt. Environmental Engineering, University of Colorado, Boulder, CO 80303, USA. Electronic address: imma.ferrer@colorado.edu.Center for Environmental Mass Spectrometry, Dpt. Environmental Engineering, University of Colorado, Boulder, CO 80303, USA.Solar Energy Research Centre (CIESOL), Joint Centre University of Almería-CIEMAT, Ctra de Sacramento s/n, 04120 Almería, Spain.Solar Energy Research Centre (CIESOL), Joint Centre University of Almería-CIEMAT, Ctra de Sacramento s/n, 04120 Almería, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30769311

Citation

Campos-Mañas, Marina Celia, et al. "Identification of Opioids in Surface and Wastewaters By LC/QTOF-MS Using Retrospective Data Analysis." The Science of the Total Environment, vol. 664, 2019, pp. 874-884.
Campos-Mañas MC, Ferrer I, Thurman EM, et al. Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. Sci Total Environ. 2019;664:874-884.
Campos-Mañas, M. C., Ferrer, I., Thurman, E. M., Sánchez Pérez, J. A., & Agüera, A. (2019). Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. The Science of the Total Environment, 664, 874-884. https://doi.org/10.1016/j.scitotenv.2019.01.389
Campos-Mañas MC, et al. Identification of Opioids in Surface and Wastewaters By LC/QTOF-MS Using Retrospective Data Analysis. Sci Total Environ. 2019 May 10;664:874-884. PubMed PMID: 30769311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis. AU - Campos-Mañas,Marina Celia, AU - Ferrer,Imma, AU - Thurman,E Michael, AU - Sánchez Pérez,José Antonio, AU - Agüera,Ana, Y1 - 2019/01/30/ PY - 2018/11/15/received PY - 2019/01/29/revised PY - 2019/01/29/accepted PY - 2019/2/16/pubmed PY - 2019/3/30/medline PY - 2019/2/16/entrez KW - Liquid chromatography KW - Opioids KW - Retrospective analysis KW - Surface water KW - Time of flight-mass spectrometry KW - Wastewater SP - 874 EP - 884 JF - The Science of the total environment JO - Sci Total Environ VL - 664 N2 - Opioids, both as prescription drugs and abuse substances, have been a hot topic and a focus of discussion in the media for the last few years. Although the literature published shows the occurrence of opioids and some of their metabolites in the aquatic environment, there are scarce data in the application of high resolution mass spectrometry (HRMS) for the analysis of these compounds in the environment. The use of HRMS allows increasing the number of opioids that can be studied as well as the detection of unknown opioids, their metabolites and potential transformation products. In this work, a retrospective analysis for the identification of opioids and their metabolites using a curated database was applied to surface water and wastewater samples taken in the state of Minnesota (U.S.) in 2009, which were previously analyzed by liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for antidepressants. The database comprised >200 opioids including natural opiates (e.g. morphine and codeine), their semi-synthetic derivatives (e.g. heroin, hydromorphone, hydrocodone, oxycodone, oxymorphone, meperidine and buprenorphine), fully synthetic opioids (e.g. fentanyl, methadone, tramadol, dextromethorphan and propoxyphene), as well as some of their metabolites (e.g. 6-monoacetylcodeine, dextrorphan, EDDP, normorphine and O-desmethyltramadol). Moreover, additional MS-MS experiments were performed to confirm their identification, as well as to recognize fragmentation patterns and diagnostic ions for several opioids. These data provide a better understanding of the historical occurrence of opioids and their metabolites in surface waters impacted by wastewater sources. The concentrations of individual opioids in surface water and wastewater effluent varied from 8.8 (EDDP) to 1640 (tramadol) ngL-1 and from 12 (dihydrocodeine) to 1288 (tramadol) ngL-1, respectively. The opioids with higher overall frequency detections were tramadol, dextromethorphan and its metabolite, dextrorphan. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/30769311/Identification_of_opioids_in_surface_and_wastewaters_by_LC/QTOF_MS_using_retrospective_data_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)30437-1 DB - PRIME DP - Unbound Medicine ER -