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Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study.
Osteoporos Int. 2019 May; 30(5):1099-1110.OI

Abstract

A retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporosis-related vertebral fractures was performed. Trabecular volumetric bone mineral density was the measurement that best discriminates between fracture and control groups.

INTRODUCTION

The aim of the present study was to evaluate the association of DXA-derived 3D measurements at the lumbar spine with osteoporosis-related vertebral fractures.

METHODS

We retrospectively analyzed a database of 74 postmenopausal women: 37 subjects with incident vertebral fractures and 37 age-matched controls without any type of fracture. DXA scans at the lumbar spine were acquired at baseline (i.e., before the fracture event for subjects in the fracture group), and areal bone mineral density (aBMD) was measured. DXA-derived 3D measurements, such as volumetric BMD (vBMD), were assessed using a DXA-based 3D modeling software (3D-SHAPER). vBMD was computed at the trabecular, cortical, and integral bone. Cortical thickness and cortical surface BMD were also measured. Differences in DXA-derived measurements between fracture and control groups were evaluated using unpaired t test. Odds ratio (OR) and area under the receiver operating curve (AUC) were also computed. Subgroup analyses according to fractured vertebra were performed.

RESULTS

aBMD of fracture group was 9.3% lower compared with control group (p < 0.01); a higher difference was found for trabecular vBMD in the vertebral body (- 16.1%, p < 0.001). Trabecular vBMD was the measurement that best discriminates between fracture and control groups, with an AUC of 0.733, against 0.682 for aBMD. Overall, similar findings were observed within the subgroup analyses. The L1 vertebral fractures subgroup had the highest AUC at trabecular vBMD (0.827), against aBMD (0.758).

CONCLUSION

This study showed the ability of cortical and trabecular measurements from DXA-derived 3D models to discriminate between fracture and control groups. Large cohorts need to be analyzed to determine if these measurements could improve fracture risk prediction in clinical practice.

Authors+Show Affiliations

Musculoskeletal Unit, Galgo Medical, Barcelona, Spain. mirella.lopez.picazo@gmail.com. BCN Medtech, Universitat Pompeu Fabra, Barcelona, Spain. mirella.lopez.picazo@gmail.com.Musculoskeletal Unit, Galgo Medical, Barcelona, Spain.CETIR Grup Mèdic, Barcelona, Spain.BCN Medtech, Universitat Pompeu Fabra, Barcelona, Spain. ICREA, Barcelona, Spain.CETIR Grup Mèdic, Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30770938

Citation

López Picazo, M, et al. "Discrimination of Osteoporosis-related Vertebral Fractures By DXA-derived 3D Measurements: a Retrospective Case-control Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 30, no. 5, 2019, pp. 1099-1110.
López Picazo M, Humbert L, Di Gregorio S, et al. Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study. Osteoporos Int. 2019;30(5):1099-1110.
López Picazo, M., Humbert, L., Di Gregorio, S., González Ballester, M. A., & Del Río Barquero, L. M. (2019). Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(5), 1099-1110. https://doi.org/10.1007/s00198-019-04894-y
López Picazo M, et al. Discrimination of Osteoporosis-related Vertebral Fractures By DXA-derived 3D Measurements: a Retrospective Case-control Study. Osteoporos Int. 2019;30(5):1099-1110. PubMed PMID: 30770938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study. AU - López Picazo,M, AU - Humbert,L, AU - Di Gregorio,S, AU - González Ballester,M A, AU - Del Río Barquero,L M, Y1 - 2019/02/15/ PY - 2018/09/07/received PY - 2019/02/08/accepted PY - 2019/2/17/pubmed PY - 2019/12/18/medline PY - 2019/2/17/entrez KW - 3D modeling KW - Fracture risk KW - Osteoporosis KW - Trabecular bone KW - Vertebral fracture KW - Volumetric bone mineral density SP - 1099 EP - 1110 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 30 IS - 5 N2 - : A retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporosis-related vertebral fractures was performed. Trabecular volumetric bone mineral density was the measurement that best discriminates between fracture and control groups. INTRODUCTION: The aim of the present study was to evaluate the association of DXA-derived 3D measurements at the lumbar spine with osteoporosis-related vertebral fractures. METHODS: We retrospectively analyzed a database of 74 postmenopausal women: 37 subjects with incident vertebral fractures and 37 age-matched controls without any type of fracture. DXA scans at the lumbar spine were acquired at baseline (i.e., before the fracture event for subjects in the fracture group), and areal bone mineral density (aBMD) was measured. DXA-derived 3D measurements, such as volumetric BMD (vBMD), were assessed using a DXA-based 3D modeling software (3D-SHAPER). vBMD was computed at the trabecular, cortical, and integral bone. Cortical thickness and cortical surface BMD were also measured. Differences in DXA-derived measurements between fracture and control groups were evaluated using unpaired t test. Odds ratio (OR) and area under the receiver operating curve (AUC) were also computed. Subgroup analyses according to fractured vertebra were performed. RESULTS: aBMD of fracture group was 9.3% lower compared with control group (p < 0.01); a higher difference was found for trabecular vBMD in the vertebral body (- 16.1%, p < 0.001). Trabecular vBMD was the measurement that best discriminates between fracture and control groups, with an AUC of 0.733, against 0.682 for aBMD. Overall, similar findings were observed within the subgroup analyses. The L1 vertebral fractures subgroup had the highest AUC at trabecular vBMD (0.827), against aBMD (0.758). CONCLUSION: This study showed the ability of cortical and trabecular measurements from DXA-derived 3D models to discriminate between fracture and control groups. Large cohorts need to be analyzed to determine if these measurements could improve fracture risk prediction in clinical practice. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/30770938/Discrimination_of_osteoporosis_related_vertebral_fractures_by_DXA_derived_3D_measurements:_a_retrospective_case_control_study_ L2 - https://doi.org/10.1007/s00198-019-04894-y DB - PRIME DP - Unbound Medicine ER -