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Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort.
Urology 2019; 127:119-123U

Abstract

OBJECTIVE

To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation.

METHODS

A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups.

RESULTS

A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5years (interquartile range [IQR] 15.2-17.6) and 30.8years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30million/mL (IQR 10-57) vs 39million/mL (IQR 14-57), P = .2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P = .01. Median total motile sperm count was 11million (IQR 1.4-33) for adolescents vs 29million (IQR 13-69) for adults, P <.001.

CONCLUSION

Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.

Authors+Show Affiliations

Department of Urology, Northwestern Feinberg School of Medicine, Chicago, IL.Department of Urology, Baylor College of Medicine, Houston, TX.Brady Urological Institute, Johns Hopkins University, Baltimore, MD.Department of Urology, University of Miami Miller School of Medicine, Miami, FL.Sidney Kimmel Medical College, Philadelphia, PA.Department of Paediatric Urology, Royal Manchester Children's Hospital, Manchester, United Kingdom.Department of Paediatric Urology, Royal Manchester Children's Hospital, Manchester, United Kingdom.Department of Urology, University of Miami Miller School of Medicine, Miami, FL.Department of Urology, University of Miami Miller School of Medicine, Miami, FL.Department of Urology, Weill Cornell Medicine, New York, NY.Department of Urology, University of Miami Miller School of Medicine, Miami, FL. Electronic address: Ramasamy@miami.edu.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

30771377

Citation

Halpern, Joshua A., et al. "Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort." Urology, vol. 127, 2019, pp. 119-123.
Halpern JA, Thirumavalavan N, Kohn TP, et al. Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. Urology. 2019;127:119-123.
Halpern, J. A., Thirumavalavan, N., Kohn, T. P., Patel, A. S., Leong, J. Y., Cervellione, R. M., ... Ramasamy, R. (2019). Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. Urology, 127, pp. 119-123. doi:10.1016/j.urology.2019.01.027.
Halpern JA, et al. Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. Urology. 2019;127:119-123. PubMed PMID: 30771377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. AU - Halpern,Joshua A, AU - Thirumavalavan,Nannan, AU - Kohn,Taylor P, AU - Patel,Amir S, AU - Leong,Joon Yau, AU - Cervellione,Raimondo M, AU - Keene,David J B, AU - Ibrahim,Emad, AU - Brackett,Nancy L, AU - Lamb,Dolores J, AU - Ramasamy,Ranjith, Y1 - 2019/02/13/ PY - 2018/11/18/received PY - 2019/01/24/revised PY - 2019/01/28/accepted PY - 2020/05/01/pmc-release PY - 2019/2/17/pubmed PY - 2019/6/27/medline PY - 2019/2/17/entrez SP - 119 EP - 123 JF - Urology JO - Urology VL - 127 N2 - OBJECTIVE: To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. METHODS: A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. RESULTS: A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5years (interquartile range [IQR] 15.2-17.6) and 30.8years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30million/mL (IQR 10-57) vs 39million/mL (IQR 14-57), P = .2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P = .01. Median total motile sperm count was 11million (IQR 1.4-33) for adolescents vs 29million (IQR 13-69) for adults, P <.001. CONCLUSION: Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/30771377/Distribution_of_Semen_Parameters_Among_Adolescent_Males_Undergoing_Fertility_Preservation_in_a_Multicenter_International_Cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(19)30134-7 DB - PRIME DP - Unbound Medicine ER -