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Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets.
Pak J Pharm Sci. 2019 Jan; 32(1):117-123.PJ

Abstract

The objective of study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. A mixture of distilled water and isopropyl alcohol (1:1) was used for wet massing. The effect of ac-di-sol on the drug release pattern was examined and dissolution profile comparison was established. All formulations followed First order and Weibull models and f2 values indicated dissimilarity with the marketed immediate release product. Taste of compacted pellets was evaluated by a panel of 12 human volunteers. Formulation P5 was found to be an optimized formulation due to satisfactory quality attributes.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30772799

Citation

Yasmin, Riffat, et al. "Formulation Development and in Vitro Evaluation of Fast Dispersible, Taste Masked Aceclofenac Compacted Pellets." Pakistan Journal of Pharmaceutical Sciences, vol. 32, no. 1, 2019, pp. 117-123.
Yasmin R, Shoaib MH, Qazi F, et al. Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets. Pak J Pharm Sci. 2019;32(1):117-123.
Yasmin, R., Shoaib, M. H., Qazi, F., Nasiri, M. I., Ali, T., Ali, H., & Zafar, F. (2019). Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets. Pakistan Journal of Pharmaceutical Sciences, 32(1), 117-123.
Yasmin R, et al. Formulation Development and in Vitro Evaluation of Fast Dispersible, Taste Masked Aceclofenac Compacted Pellets. Pak J Pharm Sci. 2019;32(1):117-123. PubMed PMID: 30772799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets. AU - Yasmin,Riffat, AU - Shoaib,Muhammad Harris, AU - Qazi,Faaiza, AU - Nasiri,Muhammad Iqbal, AU - Ali,Tariq, AU - Ali,Huma, AU - Zafar,Farya, PY - 2019/2/18/entrez PY - 2019/2/18/pubmed PY - 2019/10/16/medline SP - 117 EP - 123 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 32 IS - 1 N2 - The objective of study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. A mixture of distilled water and isopropyl alcohol (1:1) was used for wet massing. The effect of ac-di-sol on the drug release pattern was examined and dissolution profile comparison was established. All formulations followed First order and Weibull models and f2 values indicated dissimilarity with the marketed immediate release product. Taste of compacted pellets was evaluated by a panel of 12 human volunteers. Formulation P5 was found to be an optimized formulation due to satisfactory quality attributes. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/30772799/Formulation_development_and_in_vitro_evaluation_of_fast_dispersible_taste_masked_aceclofenac_compacted_pellets_ DB - PRIME DP - Unbound Medicine ER -