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Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity.
J Nutr. 2019 03 01; 149(3):471-478.JN

Abstract

BACKGROUND

Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists.

OBJECTIVES

We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial.

METHODS

In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5% MUFAs, 9.2% polyunsaturated fatty acids (PUFAs), 6.6% SFAs], HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model.

RESULTS

Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; -4.2% and -3.4%; P < 0.0001), LDL cholesterol (-6.6% and -5.6%; P < 0.0001), apoB (-3.7% and -3.4%; P = 0.002), and non-HDL cholesterol (-4.5% and -4.0%; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (-3.7% and -3.4%, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations.

CONCLUSIONS

HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity. This trial was registered at www.clinicaltrials.gov as NCT02029833.

Authors+Show Affiliations

Departments of Nutritional Sciences, The Pennsylvania State University, University Park, PA.Departments of Nutritional Sciences, The Pennsylvania State University, University Park, PA.Departments of Nutritional Sciences, The Pennsylvania State University, University Park, PA. Departments of Biobehavioral Health, The Pennsylvania State University, University Park, PA.Departments of Nutritional Sciences, The Pennsylvania State University, University Park, PA.Departments of Medicine, Toronto, ON, Canada. Laboratory Medicine and Pathobiology, Toronto, ON, Canada. Keenan Research Center for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.Institute of Nutrition and Functional Foods, Université Laval, Québec, QC, Canada.Institute of Nutrition and Functional Foods, Université Laval, Québec, QC, Canada.Departments of Medicine, Toronto, ON, Canada. Nutritional Sciences, University of Toronto, Toronto, ON, Canada. Clinical Nutrition and Risk Factor Modification Centre, Toronto, ON, Canada. Li Ka Shing Knowledge Institute, Toronto, ON, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Departments of Physiology and Pathophysiology, Winnipeg, MB, Canada. Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Center, Winnipeg, MB, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Departments of Physiology and Pathophysiology, Winnipeg, MB, Canada. Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Center, Winnipeg, MB, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.Institute of Nutrition and Functional Foods, Université Laval, Québec, QC, Canada.Institute of Nutrition and Functional Foods, Université Laval, Québec, QC, Canada.Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Center, Winnipeg, MB, Canada.Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Center, Winnipeg, MB, Canada.Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada. Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Center, Winnipeg, MB, Canada.Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada. Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30773586

Citation

Bowen, Kate J., et al. "Diets Enriched With Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet With a Western Fatty Acid Profile in Adults With Central Adiposity." The Journal of Nutrition, vol. 149, no. 3, 2019, pp. 471-478.
Bowen KJ, Kris-Etherton PM, West SG, et al. Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity. J Nutr. 2019;149(3):471-478.
Bowen, K. J., Kris-Etherton, P. M., West, S. G., Fleming, J. A., Connelly, P. W., Lamarche, B., Couture, P., Jenkins, D. J. A., Taylor, C. G., Zahradka, P., Hammad, S. S., Sihag, J., Chen, X., Guay, V., Maltais-Giguère, J., Perera, D., Wilson, A., Juan, S. C. S., Rempel, J., & Jones, P. J. H. (2019). Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity. The Journal of Nutrition, 149(3), 471-478. https://doi.org/10.1093/jn/nxy307
Bowen KJ, et al. Diets Enriched With Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet With a Western Fatty Acid Profile in Adults With Central Adiposity. J Nutr. 2019 03 1;149(3):471-478. PubMed PMID: 30773586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity. AU - Bowen,Kate J, AU - Kris-Etherton,Penny M, AU - West,Sheila G, AU - Fleming,Jennifer A, AU - Connelly,Philip W, AU - Lamarche,Benoît, AU - Couture,Patrick, AU - Jenkins,David J A, AU - Taylor,Carla G, AU - Zahradka,Peter, AU - Hammad,Shatha S, AU - Sihag,Jyoti, AU - Chen,Xiang, AU - Guay,Valérie, AU - Maltais-Giguère,Julie, AU - Perera,Danielle, AU - Wilson,Angela, AU - Juan,Sandra Castillo San, AU - Rempel,Julia, AU - Jones,Peter J H, PY - 2018/08/17/received PY - 2018/09/06/revised PY - 2018/11/21/accepted PY - 2019/2/19/pubmed PY - 2019/11/7/medline PY - 2019/2/19/entrez KW - Western diet KW - apolipoproteins KW - canola oil KW - cardiovascular disease risk KW - dietary fatty acids KW - dietary intervention KW - high-oleic acid canola oil KW - lipids KW - lipoproteins KW - metabolic syndrome SP - 471 EP - 478 JF - The Journal of nutrition JO - J Nutr VL - 149 IS - 3 N2 - BACKGROUND: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists. OBJECTIVES: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. METHODS: In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, men (n = 44) and women (n = 75) with a mean age of 44 y, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria consumed prepared, weight-maintenance diets containing canola oil [17.5% MUFAs, 9.2% polyunsaturated fatty acids (PUFAs), 6.6% SFAs], HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs) for 6 wk with ≥4-wk washouts. Fasting serum lipids were assessed at baseline and 6 wk. Diet effects were examined using a repeated measures mixed model. RESULTS: Compared with the control, canola and HOCO diets resulted in lower endpoint total cholesterol (TC; -4.2% and -3.4%; P < 0.0001), LDL cholesterol (-6.6% and -5.6%; P < 0.0001), apoB (-3.7% and -3.4%; P = 0.002), and non-HDL cholesterol (-4.5% and -4.0%; P = 0.001), with no differences between canola diets. The TC:HDL cholesterol and apoB:apoA1 ratios were lower after the HOCO diet than after the control diet (-3.7% and -3.4%, respectively). There were no diet effects on triglyceride, HDL cholesterol, or apoA1 concentrations. CONCLUSIONS: HOCO, with increased MUFAs at the expense of decreased PUFAs, elicited beneficial effects on lipids and lipoproteins comparable to conventional canola oil and consistent with reduced cardiovascular disease risk in adults with central adiposity. This trial was registered at www.clinicaltrials.gov as NCT02029833. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/30773586/Diets_Enriched_with_Conventional_or_High_Oleic_Acid_Canola_Oils_Lower_Atherogenic_Lipids_and_Lipoproteins_Compared_to_a_Diet_with_a_Western_Fatty_Acid_Profile_in_Adults_with_Central_Adiposity_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxy307 DB - PRIME DP - Unbound Medicine ER -