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Sjögren's syndrome and systemic lupus erythematosus: links and risks.
Open Access Rheumatol. 2019; 11:33-45.OA

Abstract

Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren's syndrome (pSS), or secondary Sjögren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%-17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms "Sjogren syndrome and systemic lupus erythematosus". The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS.

Authors+Show Affiliations

Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, sandra.pasoto@hc.fm.usp.br. Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Sao Paulo, Brazil, sandra.pasoto@hc.fm.usp.br.Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, sandra.pasoto@hc.fm.usp.br.Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, sandra.pasoto@hc.fm.usp.br.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30774485

Citation

Pasoto, Sandra Gofinet, et al. "Sjögren's Syndrome and Systemic Lupus Erythematosus: Links and Risks." Open Access Rheumatology : Research and Reviews, vol. 11, 2019, pp. 33-45.
Pasoto SG, Adriano de Oliveira Martins V, Bonfa E. Sjögren's syndrome and systemic lupus erythematosus: links and risks. Open Access Rheumatol. 2019;11:33-45.
Pasoto, S. G., Adriano de Oliveira Martins, V., & Bonfa, E. (2019). Sjögren's syndrome and systemic lupus erythematosus: links and risks. Open Access Rheumatology : Research and Reviews, 11, 33-45. https://doi.org/10.2147/OARRR.S167783
Pasoto SG, Adriano de Oliveira Martins V, Bonfa E. Sjögren's Syndrome and Systemic Lupus Erythematosus: Links and Risks. Open Access Rheumatol. 2019;11:33-45. PubMed PMID: 30774485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sjögren's syndrome and systemic lupus erythematosus: links and risks. AU - Pasoto,Sandra Gofinet, AU - Adriano de Oliveira Martins,Victor, AU - Bonfa,Eloisa, Y1 - 2019/01/29/ PY - 2019/2/19/entrez PY - 2019/2/19/pubmed PY - 2019/2/19/medline KW - anti-Ro KW - anti-SSA KW - autoantibodies KW - pathogenesis KW - polyautoimmunity KW - primary Sjögren’s syndrome KW - secondary Sjögren’s syndrome KW - systemic lupus erythematosus SP - 33 EP - 45 JF - Open access rheumatology : research and reviews JO - Open Access Rheumatol VL - 11 N2 - Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren's syndrome (pSS), or secondary Sjögren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%-17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms "Sjogren syndrome and systemic lupus erythematosus". The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. SN - 1179-156X UR - https://www.unboundmedicine.com/medline/citation/30774485/Sjögren's_syndrome_and_systemic_lupus_erythematosus:_links_and_risks_ L2 - https://dx.doi.org/10.2147/OARRR.S167783 DB - PRIME DP - Unbound Medicine ER -
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