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Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.
J Alzheimers Dis 2019; 68(2):517-521JA

Abstract

We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Kaiser Permanente Center for Health Research, Portland, OR, USA.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.Department of Radiology, Neurology, Psychiatry, and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30775981

Citation

Rawlings, Andreea M., et al. "Cognitive Reserve in Midlife Is Not Associated With Amyloid-β Deposition in Late-Life." Journal of Alzheimer's Disease : JAD, vol. 68, no. 2, 2019, pp. 517-521.
Rawlings AM, Sharrett AR, Mosley TH, et al. Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life. J Alzheimers Dis. 2019;68(2):517-521.
Rawlings, A. M., Sharrett, A. R., Mosley, T. H., Wong, D. F., Knopman, D. S., & Gottesman, R. F. (2019). Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life. Journal of Alzheimer's Disease : JAD, 68(2), pp. 517-521. doi:10.3233/JAD-180785.
Rawlings AM, et al. Cognitive Reserve in Midlife Is Not Associated With Amyloid-β Deposition in Late-Life. J Alzheimers Dis. 2019;68(2):517-521. PubMed PMID: 30775981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life. AU - Rawlings,Andreea M, AU - Sharrett,A Richey, AU - Mosley,Thomas H, AU - Wong,Dean F, AU - Knopman,David S, AU - Gottesman,Rebecca F, PY - 2020/01/01/pmc-release PY - 2019/2/19/pubmed PY - 2019/2/19/medline PY - 2019/2/19/entrez KW - Amyloid KW - PET imaging KW - cohort study KW - education KW - epidemiology KW - human SP - 517 EP - 521 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 68 IS - 2 N2 - We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/30775981/Cognitive_Reserve_in_Midlife_is_not_Associated_with_Amyloid_β_Deposition_in_Late_Life_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-180785 DB - PRIME DP - Unbound Medicine ER -