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Cisapride and metoclopramide in the treatment of gastroesophageal reflux disease.
Clin Ther 1988; 10(4):421-8CT

Abstract

In a double-blind, randomized study, the clinical effects of 5 mg and 10 mg of cisapride three times daily were compared with those of 10 mg of metoclopramide three times daily in 114 patients with symptoms of gastroesophageal reflux, mainly diurnal and nocturnal heartburn and regurgitation. The symptoms significantly (P less than 0.001) improved in the three groups; the mean severity score decreased by at least 78% after four weeks of treatment. Initial symptoms were more severe in the cisapride-treated patients, especially in those receiving 10 mg three times daily; however, the patients' condition after four weeks was similar in the three groups. Central nervous system side effects were reported by one patient from each of the cisapride-treated groups and by nine of the 43 metoclopramide-treated patients (P less than 0.02). Six metoclopramide-treated patients and one cisapride-treated patient dropped out of the study because of side effects. These findings favor the use of cisapride when prokinetic treatment of gastroesophageal reflux is considered.

Authors+Show Affiliations

Hospital de Clínicas José de San Martín, National University of Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

3079010

Citation

Arabehety, J T., et al. "Cisapride and Metoclopramide in the Treatment of Gastroesophageal Reflux Disease." Clinical Therapeutics, vol. 10, no. 4, 1988, pp. 421-8.
Arabehety JT, Leitão OR, Fassler S, et al. Cisapride and metoclopramide in the treatment of gastroesophageal reflux disease. Clin Ther. 1988;10(4):421-8.
Arabehety, J. T., Leitão, O. R., Fassler, S., Olarte, M., & Serrano, C. (1988). Cisapride and metoclopramide in the treatment of gastroesophageal reflux disease. Clinical Therapeutics, 10(4), pp. 421-8.
Arabehety JT, et al. Cisapride and Metoclopramide in the Treatment of Gastroesophageal Reflux Disease. Clin Ther. 1988;10(4):421-8. PubMed PMID: 3079010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cisapride and metoclopramide in the treatment of gastroesophageal reflux disease. AU - Arabehety,J T, AU - Leitão,O R, AU - Fassler,S, AU - Olarte,M, AU - Serrano,C, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 421 EP - 8 JF - Clinical therapeutics JO - Clin Ther VL - 10 IS - 4 N2 - In a double-blind, randomized study, the clinical effects of 5 mg and 10 mg of cisapride three times daily were compared with those of 10 mg of metoclopramide three times daily in 114 patients with symptoms of gastroesophageal reflux, mainly diurnal and nocturnal heartburn and regurgitation. The symptoms significantly (P less than 0.001) improved in the three groups; the mean severity score decreased by at least 78% after four weeks of treatment. Initial symptoms were more severe in the cisapride-treated patients, especially in those receiving 10 mg three times daily; however, the patients' condition after four weeks was similar in the three groups. Central nervous system side effects were reported by one patient from each of the cisapride-treated groups and by nine of the 43 metoclopramide-treated patients (P less than 0.02). Six metoclopramide-treated patients and one cisapride-treated patient dropped out of the study because of side effects. These findings favor the use of cisapride when prokinetic treatment of gastroesophageal reflux is considered. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/3079010/Cisapride_and_metoclopramide_in_the_treatment_of_gastroesophageal_reflux_disease_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -